# LCP1

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**Plastin-2** is a [protein](/source/Protein) that in humans is encoded by the *LCP1* [gene](/source/Gene).[1]

## Function

[Plastins](/source/Plastin) are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as [fimbrin](/source/Fimbrin)) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-[hemopoietic](/source/Hemopoietic) origin suggesting that its expression is induced accompanying [tumorigenesis](/source/Tumorigenesis) in solid tissues.[2]

## References

1. Zu Y, Kohno M, Kubota I, Nishida E, Hanaoka M, Namba Y (January 1990). "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". *Biochemistry*. **29** (4): 1055–62. [doi:10.1021/bi00456a030](https://doi.org/10.1021/bi00456a030). [PMID 2111166](https://pubmed.ncbi.nlm.nih.gov/2111166)

1. ["Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3936)

## Further reading

- Namba Y, Ito M, Zu Y, Shigesada K, Maruyama K (October 1992). "Human T cell L-plastin bundles actin filaments in a calcium-dependent manner". *Journal of Biochemistry*. **112** (4): 503–7. [doi:10.1093/oxfordjournals.jbchem.a123929](https://doi.org/10.1093/oxfordjournals.jbchem.a123929). [PMID 1491005](https://pubmed.ncbi.nlm.nih.gov/1491005)
- Zu YL, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, Namba Y (September 1990). "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites". *Biochemistry*. **29** (36): 8319–24. [doi:10.1021/bi00488a017](https://doi.org/10.1021/bi00488a017). [PMID 2252891](https://pubmed.ncbi.nlm.nih.gov/2252891)
- Lin CS, Aebersold RH, Leavitt J (April 1990). "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain". *Molecular and Cellular Biology*. **10** (4): 1818–21. [doi:10.1128/MCB.10.4.1818](https://doi.org/10.1128/MCB.10.4.1818). [PMC 362293](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC362293). [PMID 2378651](https://pubmed.ncbi.nlm.nih.gov/2378651)
- Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J (November 1988). "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts". *Molecular and Cellular Biology*. **8** (11): 4659–68. [doi:10.1128/MCB.8.11.4659](https://doi.org/10.1128/MCB.8.11.4659). [PMC 365555](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC365555). [PMID 3211125](https://pubmed.ncbi.nlm.nih.gov/3211125)
- Matsushima K, Shiroo M, Kung HF, Copeland TD (May 1988). "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1". *Biochemistry*. **27** (10): 3765–70. [doi:10.1021/bi00410a037](https://doi.org/10.1021/bi00410a037). [PMID 3261603](https://pubmed.ncbi.nlm.nih.gov/3261603)
- Kondo I, Shin K, Honmura S, Nakajima H, Yamamura E, Satoh H, Terauchi M, Usuki Y, Takita H, Hamaguchi H (1986). "A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13". *Human Genetics*. **71** (3): 263–6. [doi:10.1007/BF00284588](https://doi.org/10.1007/BF00284588). [PMID 3864729](https://pubmed.ncbi.nlm.nih.gov/3864729). [S2CID 11261385](https://api.semanticscholar.org/CorpusID:11261385)
- Arpin M, Friederich E, Algrain M, Vernel F, Louvard D (December 1994). "Functional differences between L- and T-plastin isoforms". *The Journal of Cell Biology*. **127** (6 Pt 2): 1995–2008. [doi:10.1083/jcb.127.6.1995](https://doi.org/10.1083/jcb.127.6.1995). [PMC 2120298](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120298). [PMID 7806577](https://pubmed.ncbi.nlm.nih.gov/7806577)
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi:10.1016/0378-1119(94)90802-8](https://doi.org/10.1016/0378-1119(94)90802-8). [PMID 8125298](https://pubmed.ncbi.nlm.nih.gov/8125298)
- Lin CS, Shen W, Chen ZP, Tu YH, Matsudaira P (April 1994). "Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney". *Molecular and Cellular Biology*. **14** (4): 2457–67. [doi:10.1128/mcb.14.4.2457](https://doi.org/10.1128/mcb.14.4.2457). [PMC 358613](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC358613). [PMID 8139549](https://pubmed.ncbi.nlm.nih.gov/8139549)
- Lin CS, Park T, Chen ZP, Leavitt J (February 1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells". *The Journal of Biological Chemistry*. **268** (4): 2781–92. [doi:10.1016/S0021-9258(18)53842-4](https://doi.org/10.1016/S0021-9258(18)53842-4). [PMID 8428952](https://pubmed.ncbi.nlm.nih.gov/8428952)
- Lin CS, Chen ZP, Park T, Ghosh K, Leavitt J (February 1993). "Characterization of the human L-plastin gene promoter in normal and neoplastic cells". *The Journal of Biological Chemistry*. **268** (4): 2793–801. [doi:10.1016/S0021-9258(18)53843-6](https://doi.org/10.1016/S0021-9258(18)53843-6). [PMID 8428953](https://pubmed.ncbi.nlm.nih.gov/8428953)
- Jones SL, Brown EJ (June 1996). "FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils". *The Journal of Biological Chemistry*. **271** (24): 14623–30. [doi:10.1074/jbc.271.24.14623](https://doi.org/10.1074/jbc.271.24.14623). [PMID 8663066](https://pubmed.ncbi.nlm.nih.gov/8663066)
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi:10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016/S0378-1119(97)00411-3). [PMID 9373149](https://pubmed.ncbi.nlm.nih.gov/9373149)
- Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H (January 1999). "The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin". *FEBS Letters*. **442** (1): 39–42. [doi:10.1016/S0014-5793(98)01612-3](https://doi.org/10.1016/S0014-5793(98)01612-3). [PMID 9923600](https://pubmed.ncbi.nlm.nih.gov/9923600). [S2CID 40872647](https://api.semanticscholar.org/CorpusID:40872647)
- Wang J, Brown EJ (August 1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A". *The Journal of Biological Chemistry*. **274** (34): 24349–56. [doi:10.1074/jbc.274.34.24349](https://doi.org/10.1074/jbc.274.34.24349). [PMID 10446213](https://pubmed.ncbi.nlm.nih.gov/10446213)
- Lin CS, Lau A, Yeh CC, Chang CH, Lue TF (January 2000). "Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences". *DNA and Cell Biology*. **19** (1): 1–7. [doi:10.1089/104454900314654](https://doi.org/10.1089/104454900314654). [PMID 10668786](https://pubmed.ncbi.nlm.nih.gov/10668786)
- Jia J, Han Q, Borregaard N, Lollike K, Cygler M (July 2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". *Journal of Molecular Biology*. **300** (5): 1271–81. [doi:10.1006/jmbi.2000.3925](https://doi.org/10.1006/jmbi.2000.3925). [PMID 10903868](https://pubmed.ncbi.nlm.nih.gov/10903868)
- Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA (May 2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". *The Journal of Biological Chemistry*. **276** (21): 17762–9. [doi:10.1074/jbc.M100965200](https://doi.org/10.1074/jbc.M100965200). [PMID 11279160](https://pubmed.ncbi.nlm.nih.gov/11279160)
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". *Genome Research*. **11** (10): 1758–65. [doi:10.1101/gr.180101](https://doi.org/10.1101/gr.180101). [PMC 311163](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311163). [PMID 11591653](https://pubmed.ncbi.nlm.nih.gov/11591653)

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Adapted from the Wikipedia article [LCP1](https://en.wikipedia.org/wiki/LCP1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/LCP1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.