# LCOR

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Protein-coding gene in the species Homo sapiens

LCOR Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COB Identifiers Aliases LCOR, MLR2, ligand dependent nuclear receptor corepressor, C10orf12 External IDs OMIM: 607698; MGI: 2443930; HomoloGene: 22914; GeneCards: LCOR; OMA:LCOR - orthologs Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 96,832,254 bp[1] End 96,995,956 bp[1] Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 41,471,076 bp[2] End 41,574,975 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa mucosa of paranasal sinus mucosa of ileum visceral pleura cardia pylorus renal medulla nipple mucosa of sigmoid colon Top expressed in epithelium of stomach ventromedial nucleus migratory enteric neural crest cell Rostral migratory stream ciliary body lateral septal nucleus mammillary body human fetus retinal pigment epithelium left colon More reference expression data BioGPS n/a Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 84458 212391 Ensembl ENSG00000196233 ENSMUSG00000025019 UniProt Q96JN0 Q6ZPI3 RefSeq (mRNA) NM_001170765 NM_001170766 NM_001346516 NM_015652 NM_032440 NM_172154 NM_001370767 RefSeq (protein) NP_001164236 NP_001164237 NP_001333445 NP_115816 NP_742166 NP_001357696 Location (UCSC) Chr 10: 96.83 – 97 Mb Chr 19: 41.47 – 41.57 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Ligand-dependent corepressor** is a [protein](/source/Protein) that in humans is encoded by the *LCOR* [gene](/source/Gene).[5][6][7]

## Function

LCOR is a transcriptional [corepressor](/source/Corepressor_(genetics)) widely expressed in fetal and adult tissues that is recruited to agonist-bound [nuclear receptors](/source/Nuclear_receptor) through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000196233](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000196233) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000025019](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000025019) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=84458). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=212391). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid12535528_5-0)** Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003). ["Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms"](https://doi.org/10.1016%2FS1097-2765%2803%2900014-5). *Mol Cell*. **11** (1): 139–50. [doi](/source/Doi_(identifier)):[10.1016/S1097-2765(03)00014-5](https://doi.org/10.1016%2FS1097-2765%2803%2900014-5). [PMID](/source/PMID_(identifier)) [12535528](https://pubmed.ncbi.nlm.nih.gov/12535528).

1. **[^](#cite_ref-pmid15193453_6-0)** White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". *Vitam Horm*. Vitamins & Hormones. **68**: 123–43. [doi](/source/Doi_(identifier)):[10.1016/S0083-6729(04)68004-6](https://doi.org/10.1016%2FS0083-6729%2804%2968004-6). [ISBN](/source/ISBN_(identifier)) [978-0-12-709868-5](https://en.wikipedia.org/wiki/Special:BookSources/978-0-12-709868-5). [PMID](/source/PMID_(identifier)) [15193453](https://pubmed.ncbi.nlm.nih.gov/15193453).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: LCOR ligand dependent nuclear receptor corepressor"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=84458).

## Further reading

- Nagase T, Nakayama M, Nakajima D, et al. (2001). ["Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"](https://doi.org/10.1093%2Fdnares%2F8.2.85). *DNA Res*. **8** (2): 85–95. [doi](/source/Doi_(identifier)):[10.1093/dnares/8.2.85](https://doi.org/10.1093%2Fdnares%2F8.2.85). [PMID](/source/PMID_(identifier)) [11347906](https://pubmed.ncbi.nlm.nih.gov/11347906).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". *FEBS Lett*. **535** (1–3): 61–5. [doi](/source/Doi_(identifier)):[10.1016/S0014-5793(02)03858-9](https://doi.org/10.1016%2FS0014-5793%2802%2903858-9). [PMID](/source/PMID_(identifier)) [12560079](https://pubmed.ncbi.nlm.nih.gov/12560079). [S2CID](/source/S2CID_(identifier)) [83745027](https://api.semanticscholar.org/CorpusID:83745027).

- Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". *Nature*. **422** (6933): 735–8. [Bibcode](/source/Bibcode_(identifier)):[2003Natur.422..735S](https://ui.adsabs.harvard.edu/abs/2003Natur.422..735S). [doi](/source/Doi_(identifier)):[10.1038/nature01550](https://doi.org/10.1038%2Fnature01550). [PMID](/source/PMID_(identifier)) [12700765](https://pubmed.ncbi.nlm.nih.gov/12700765). [S2CID](/source/S2CID_(identifier)) [2670859](https://api.semanticscholar.org/CorpusID:2670859).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). ["The DNA sequence and comparative analysis of human chromosome 10"](https://doi.org/10.1038%2Fnature02462). *Nature*. **429** (6990): 375–81. [Bibcode](/source/Bibcode_(identifier)):[2004Natur.429..375D](https://ui.adsabs.harvard.edu/abs/2004Natur.429..375D). [doi](/source/Doi_(identifier)):[10.1038/nature02462](https://doi.org/10.1038%2Fnature02462). [PMID](/source/PMID_(identifier)) [15164054](https://pubmed.ncbi.nlm.nih.gov/15164054).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

## External links

- [PDBe-KB](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q96JN0) provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor

v t e PDB gallery 2cob: Solution structures of the HTH domain of human LCoR protein

v t e Transcription coregulators Coactivators ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140) Corepressors CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT) ATP-dependent remodeling factors RSC SWI/SNF

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

- [v](https://en.wikipedia.org/wiki/Template:Gene-10-stub)
- [t](/source/Template_talk%3AGene-10-stub)
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Adapted from the Wikipedia article [LCOR](https://en.wikipedia.org/wiki/LCOR) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/LCOR?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.