# Ki Database

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Ki_Database
> Markdown URL: https://mediated.wiki/source/Ki_Database.md
> Source: https://en.wikipedia.org/wiki/Ki_Database
> Source revision: 1356760902
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Public domain database of binding affinities for drugs and other chemical compounds

NIMH PDSP Founded August 2006 Headquarters Chapel Hill, North Carolina Key people Director: Bryan Roth MD, PhD Website PDSP home page

The **Ki Database** (or **Ki DB**) is a [public domain](/source/Public_domain) [bioinformatics](/source/Bioinformatics) database of published [binding affinities](/source/Dissociation_constant) (*K*i) of [drugs](/source/Drugs) and other chemical compounds for a wide range of biological targets. The database primarily stores [inhibition constant](/source/Inhibition_constant) (*K*i) values, which measure the potency of a compound in inhibiting the binding of a radioligand to a specific target, such as a [receptor](/source/Receptor_(biochemistry)), [neurotransmitter transporter](/source/Neurotransmitter_transporter), [ion channel](/source/Ion_channel), or [enzyme](/source/Enzyme).[1]

The resource is maintained by the [University of North Carolina at Chapel Hill](/source/University_of_North_Carolina_at_Chapel_Hill) and is funded by the [NIMH](/source/National_Institute_of_Mental_Health) Psychoactive Drug Screening Program and by a gift from the [Heffter Research Institute](/source/Heffter_Research_Institute). As of April 2010[\[update\]](https://en.wikipedia.org/w/index.php?title=Ki_Database&action=edit), the database had data for 7,449 compounds at 738 different receptors and, as of 27 April 2018[\[update\]](https://en.wikipedia.org/w/index.php?title=Ki_Database&action=edit), 67 696 *K*i values.[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed)*]

## Purpose and uses

The Ki Database serves as a data warehouse for both internally generated data and data curated from published scientific literature. It is created and maintained by the [National Institute of Mental Health](/source/National_Institute_of_Mental_Health) (NIMH) Psychoactive Drug Screening Program (PDSP), which is based at the [University of North Carolina at Chapel Hill](/source/University_of_North_Carolina_at_Chapel_Hill) and directed by pharmacologist [Bryan L. Roth](/source/Bryan_L._Roth).[1][2] The resource is a key tool in the fields of [pharmacology](/source/Pharmacology), [medicinal chemistry](/source/Medicinal_chemistry), and [neuroscience](/source/Neuroscience) for identifying the molecular targets of psychoactive compounds, predicting off-target effects, and guiding drug discovery efforts.[3]

As of 2017, the PDSP was testing an average of 4,000 compounds in over 215,000 assays annually, with the data being made publicly available through the database.[2] The program is supported by an NIMH contract and has also received funding from the Heffter Research Institute.[1] The Ki database has data useful for both chemical biology and [chemogenetics](/source/Chemogenetics).

## See also

- [BindingDB](/source/BindingDB)

- [ChEMBL](/source/ChEMBL)

- [DrugBank](/source/DrugBank)

- [Guide to PHARMACOLOGY](/source/Guide_to_PHARMACOLOGY)

- [Inhibition constant](/source/Inhibition_constant) (*K*i)

## References

1. ^ [***a***](#cite_ref-PDSPHome_1-0) [***b***](#cite_ref-PDSPHome_1-1) [***c***](#cite_ref-PDSPHome_1-2) ["Ki Database"](https://pdspdb.unc.edu/databases/kidb.php). NIMH Psychoactive Drug Screening Program. [Archived](https://web.archive.org/web/20240618012652/https://pdspdb.unc.edu/databases/kidb.php) from the original on 18 June 2024. Retrieved 15 July 2024.

1. ^ [***a***](#cite_ref-NIMHConcept2017_2-0) [***b***](#cite_ref-NIMHConcept2017_2-1) ["The NIMH Psychoactive Drug Screening Program (PDSP)"](https://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2017/the-nimh-psychoactive-drug-screening-program-pdsp). *National Institute of Mental Health (NIMH)*. 25 May 2017. Retrieved 15 July 2024.

1. **[^](#cite_ref-Besnard2012_3-0)** Besnard, J; Ruda, GF; Setola, V; Abecassis, K; Rodriguiz, RM; Huang, XP; Norval, S; Sassano, MF; Shin, AI; Webster, LA; Simeons, FR; Stojanovski, L; Prat, A; Seidah, NG; Constam, DB; Bickerton, GR; Read, KD; Wetsel, WC; Gilbert, IH; Roth, BL; Hopkins, AL (13 December 2012). ["Automated design of ligands to polypharmacological profiles"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653568). *Nature*. **492** (7428): 215–220. [doi](/source/Doi_(identifier)):[10.1038/nature11691](https://doi.org/10.1038%2Fnature11691). [PMC](/source/PMC_(identifier)) [3653568](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653568). [PMID](/source/PMID_(identifier)) [23235874](https://pubmed.ncbi.nlm.nih.gov/23235874).

## External links

- [Description](https://pdsp.unc.edu/databases/kidb.php)

- [Search form](https://pdsp.unc.edu/databases/pdsp.php)

- [BindingDB.org - A similar publicly available database](https://www.bindingdb.org/bind/index.jsp) [Archived](https://web.archive.org/web/20210122231814/http://bindingdb.org/bind/index.jsp) 22 January 2021 at the [Wayback Machine](/source/Wayback_Machine)

---
Adapted from the Wikipedia article [Ki Database](https://en.wikipedia.org/wiki/Ki_Database) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Ki_Database?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.