# Jason Locasale

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{{short description|American scientist}}
{{Infobox scientist
| name              = Jason Locasale
| image             = 
| image_size        = 154px
| caption           = Jason Locasale
| birth_place       = New Jersey, U.S.
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| residence         = 
| alma_mater        = [Rutgers University](/source/Rutgers_University) <small>([B.A.](/source/Bachelor_of_Science))</small><br />[Massachusetts Institute of Technology](/source/Massachusetts_Institute_of_Technology) <small>([Ph.D.](/source/Doctor_of_Philosophy))</small><br />[Harvard University](/source/Harvard_University) <small>([Postdoctoral Fellowship](/source/Postdoctoral_researcher))</small>
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| known_for         = 
| author_abbrev_bot = 
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| influences        = 
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| signature         = 
| footnotes         = 
| fields            = [Cancer Research](/source/Cancer_Research), [Metabolism](/source/Metabolism), [Metabolomics](/source/Metabolomics), [Nutrition](/source/Nutrition)
| work_institutions = Duke University
| party             = 
| academic_advisors = [Lewis C. Cantley](/source/Lewis_C._Cantley)
| prizes            = 
}}
'''Jason W. Locasale''' is an American scientist and university professor. His focus is on [metabolism](/source/metabolism).

== Education ==
Locasale graduated summa cum laude from [Rutgers University](/source/Rutgers_University) with a dual degree in Chemistry and Physics. While completing his undergraduate degree, he received initial training in research in [biochemistry](/source/biochemistry) and [structural biology](/source/structural_biology) under [Helen Berman](/source/Helen_M._Berman). He earned a Ph.D. from the [Massachusetts Institute of Technology](/source/Massachusetts_Institute_of_Technology). He went on to complete a postdoctoral fellowship at [Harvard Medical School](/source/Harvard_Medical_School) under [Lewis C. Cantley](/source/Lewis_C._Cantley).<ref>{{Cite web|url=https://www.dukechronicle.com/article/2019/09/duke-university-jason-locasale-fighting-cancer-chemical|title=Jason Locasale: Fighting cancer with chemical complexity and collaboration|website=The Chronicle|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://www.cell-symposia.com/metabolites-2018/bio-locasale.asp|title=Speaker: Cell Symposia: Metabolites as Signalling Molecules|website=www.cell-symposia.com|access-date=2019-12-01}}</ref>

He was an associate professor with tenure until 2024 at [Duke University School of Medicine](/source/Duke_University_School_of_Medicine).<ref>{{Cite web|url=https://medschool.duke.edu/about-us/our-faculty/jason-locasale|title=Jason Locasale {{!}} Duke School of Medicine|website=medschool.duke.edu|access-date=2019-12-01|archive-date=2019-09-27|archive-url=https://web.archive.org/web/20190927141925/https://medschool.duke.edu/about-us/our-faculty/jason-locasale|url-status=dead}}</ref>

== Research ==
Locasale has pioneered the use of methods to study [metabolism](/source/metabolism) using primarily [liquid chromatography-mass spectrometry (LC-MS)](/source/Liquid_chromatography%E2%80%93mass_spectrometry),<ref>{{Cite journal|last1=Liu|first1=Xiaojing|last2=Ser|first2=Zheng|last3=Locasale|first3=Jason W|date=2014-02-18|title=Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology|journal=Analytical Chemistry|volume=86|issue=4|pages=2175–2184|doi=10.1021/ac403845u|issn=0003-2700|pmc=3983012|pmid=24410464}}</ref> in particular having developed methods to gain insights into numerous biological processes at once.<ref>{{Cite web|url=https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2016/cancer-metabolism-locasale|title=Cancer Metabolism: A Conversation with Jason Locasale|date=2016-11-28|website=National Cancer Institute|access-date=2019-12-01}}</ref> He has made contributions to understanding the role of [serine synthesis](/source/Phosphoglycerate_dehydrogenase) and [one carbon metabolism](/source/Folate) in cancers,<ref>{{Cite journal|last=Locasale|first=Jason W.|date=August 2013|title=Serine, glycine and one-carbon units: cancer metabolism in full circle|journal=Nature Reviews Cancer|volume=13|issue=8|pages=572–583|doi=10.1038/nrc3557|issn=1474-1768|pmc=3806315|pmid=23822983}}</ref><ref>{{Cite journal|last1=Gao|first1=Xia|last2=Lee|first2=Katie|last3=Reid|first3=Michael A.|last4=Sanderson|first4=Sydney M.|last5=Qiu|first5=Chuping|last6=Li|first6=Siqi|last7=Liu|first7=Juan|last8=Locasale|first8=Jason W.|date=2018-03-27|title=Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism|url= |journal=Cell Reports|volume=22|issue=13|pages=3507–3520|doi=10.1016/j.celrep.2018.03.017|issn=2211-1247|pmc=6054483|pmid=29590619}}</ref><ref>{{Cite journal|last1=Locasale|first1=Jason W.|last2=Grassian|first2=Alexandra R.|last3=Melman|first3=Tamar|last4=Lyssiotis|first4=Costas A.|last5=Mattaini|first5=Katherine R.|last6=Bass|first6=Adam J.|last7=Heffron|first7=Gregory|last8=Metallo|first8=Christian M.|last9=Muranen|first9=Taru|last10=Sharfi|first10=Hadar|last11=Sasaki|first11=Atsuo T.|date=September 2011|title=Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis|journal=Nature Genetics|language=en|volume=43|issue=9|pages=869–874|doi=10.1038/ng.890|pmid=21804546|issn=1546-1718|pmc=3677549}}</ref><ref>{{Cite journal|last1=Reid|first1=Michael A.|last2=Allen|first2=Annamarie E.|last3=Liu|first3=Shiyu|last4=Liberti|first4=Maria V.|last5=Liu|first5=Pei|last6=Liu|first6=Xiaojing|last7=Dai|first7=Ziwei|last8=Gao|first8=Xia|last9=Wang|first9=Qian|last10=Liu|first10=Ying|last11=Lai|first11=Luhua|date=2018-12-21|title=Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism|journal=Nature Communications|language=en|volume=9|issue=1|pages=5442|doi=10.1038/s41467-018-07868-6|pmid=30575741|pmc=6303315|issn=2041-1723|bibcode=2018NatCo...9.5442R|doi-access=free}}</ref><ref>{{Cite journal|last1=Mehrmohamadi|first1=Mahya|last2=Liu|first2=Xiaojing|last3=Shestov|first3=Alexander A.|last4=Locasale|first4=Jason W.|date=2014-11-20|title=Characterization of the Usage of the Serine Metabolic Network in Human Cancer|url= |journal=Cell Reports|language=en|volume=9|issue=4|pages=1507–1519|doi=10.1016/j.celrep.2014.10.026|issn=2211-1247|pmid=25456139|pmc=4317399}}</ref> defining the quantitative, mechanistic principles of the [Warburg Effect](/source/Warburg_effect_(oncology))<ref>{{Cite journal|last1=Liberti|first1=Maria V.|last2=Locasale|first2=Jason W.|date=March 2016|title=The Warburg Effect: How Does it Benefit Cancer Cells?|journal=Trends in Biochemical Sciences|volume=41|issue=3|pages=211–218|doi=10.1016/j.tibs.2015.12.001|issn=0968-0004|pmc=4783224|pmid=26778478}}</ref> and altered [glucose metabolism](/source/Carbohydrate_metabolism) in cancer,<ref>{{Cite journal|last1=Liberti|first1=Maria V.|last2=Dai|first2=Ziwei|last3=Wardell|first3=Suzanne E.|last4=Baccile|first4=Joshua A.|last5=Liu|first5=Xiaojing|last6=Gao|first6=Xia|last7=Baldi|first7=Robert|last8=Mehrmohamadi|first8=Mahya|last9=Johnson|first9=Marc O.|last10=Madhukar|first10=Neel S.|last11=Shestov|first11=Alexander A.|date=2017-10-03|title=A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product|journal=Cell Metabolism|volume=26|issue=4|pages=648–659.e8|doi=10.1016/j.cmet.2017.08.017|issn=1932-7420|pmc=5629112|pmid=28918937}}</ref> and the role of metabolism in mediating [chromatin](/source/chromatin) status and [epigenetics](/source/epigenetics).<ref>{{Cite journal|last1=Mentch|first1=Samantha J.|last2=Mehrmohamadi|first2=Mahya|last3=Huang|first3=Lei|last4=Liu|first4=Xiaojing|last5=Gupta|first5=Diwakar|last6=Mattocks|first6=Dwight|last7=Gómez Padilla|first7=Paola|last8=Ables|first8=Gene|last9=Bamman|first9=Marcas M.|last10=Thalacker-Mercer|first10=Anna E.|last11=Nichenametla|first11=Sailendra N.|date=2015-11-03|title=Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism|url= |journal=Cell Metabolism|volume=22|issue=5|pages=861–873|doi=10.1016/j.cmet.2015.08.024|issn=1550-4131|pmc=4635069|pmid=26411344}}</ref><ref>{{Cite web|url=https://www.the-scientist.com/lab-tools/high-throughput-epigenetics-analyses-30163|title=High-Throughput Epigenetics Analyses|website=The Scientist Magazine®|language=en|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://www.sciencedaily.com/releases/2017/01/170116121823.htm|title=Potentially reversible changes in gene control 'prime' pancreatic cancer cells to spread: Epigenetic changes, not DNA mutations, drive some metastasis|website=ScienceDaily|language=en|access-date=2019-12-25}}</ref> His recent work which has gained widespread public attention<ref>{{Cite web|url=https://www.medicalnewstoday.com/articles/325939.php|title=How a dietary change might boost cancer therapy|website=Medical News Today|date=4 August 2019 |language=en|access-date=2019-12-25}}</ref><ref>{{Cite web|url=https://www.myhighplains.com/news/for-your-health/vegan-diets-may-help-boost-cancer-treatments/|title=Vegan diets may help boost cancer treatments|date=2019-08-06|website=KAMR - MyHighPlains.com|language=en-US|access-date=2019-12-25}}</ref><ref>{{Cite web|url=https://www.thelondoneconomic.com/lifestyle/health/going-vegan-really-can-prevent-cancer/31/07/|title=Going vegan 'really can prevent cancer'|last=Says|first=Dyljohbar|date=2019-07-31|website=The London Economic|language=en-GB|access-date=2019-12-28|archive-date=2019-12-28|archive-url=https://web.archive.org/web/20191228230233/https://www.thelondoneconomic.com/lifestyle/health/going-vegan-really-can-prevent-cancer/31/07/|url-status=dead}}</ref><ref>{{Cite web|url=https://medium.com/@Kahn642/a-low-methionine-diet-new-data-for-cancer-therapy-favors-plant-foods-35aa2af536ce|title=A Low Methionine Diet: New Data for Cancer Therapy Favors Plant Foods|last=Kahn|first=Joel|date=2019-08-05|website=Medium|language=en|access-date=2019-12-28}}</ref> has focused on the effects on dietary [methionine](/source/methionine) restriction and diet in general as a therapeutic approach<ref>{{Cite web|url=https://www.theatlantic.com/health/archive/2019/05/food-cancer/589714/|title=You Can't 'Starve' Cancer, but You Might Help Treat It With Food|last=Hamblin|first=James|date=2019-05-20|website=The Atlantic|language=en-US|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://www.cancer.gov/news-events/cancer-currents-blog/2019/targeting-cancer-metabolism-low-methionine-diet|title=Altering Diet to Enhance Cancer Treatment Response|date=2019-09-03|website=National Cancer Institute|language=en|access-date=2019-12-13}}</ref> to extend lifespan and shape tumor response to therapy.<ref>{{Cite web|url=https://elemental.medium.com/feeding-the-beast-could-eating-the-right-diet-starve-cancers-like-mine-7d621ecf7cfb|title=Feeding the Beast: Could Eating the Right Diet Starve Cancers Like Mine?|last=Stern|first=Adam Philip|date=2019-06-17|website=Medium|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://news.yahoo.com/diet-help-cancer-treatment-study-mice-offers-clues-180127830.html|title=Can diet help cancer treatment? Study in mice offers clues|website=news.yahoo.com|language=en-US|access-date=2019-12-08}}</ref><ref>{{Cite web|url=https://cen.acs.org/biological-chemistry/cancer/Mice-fed-low-methionine-diet/97/web/2019/08|title=Mice fed a low-methionine diet respond better to cancer treatments|website=Chemical & Engineering News|language=en|access-date=2019-12-08}}</ref>

His research approaches integrate [computational modeling](/source/computational_modeling), cell biology, mouse models, and genetic and biochemical experimentation to understand metabolic processes and their contribution to health.<ref>{{Cite web|url=http://www.jlocasale.duke.edu/|title=HOME|website=Locasale Lab|access-date=2019-12-01}}</ref>{{Primary source inline|date=January 2020|reason=Article should not cite the lab website, which the subject of the article is capable of editing. A proper non-primary source is needed here.}}  Currently, his research is in three interconnected areas: (1) Quantitative biology of metabolism, (2) Dietary interventions and metabolic therapeutics in health and cancer, and (3) The mechanistic basis between the interaction of metabolism and epigenetics.<ref name=":0">{{Cite journal|date=1970-01-01|title=Editorial Board|url=https://www.cell-stress.com/about-us/editorial-board/|journal=Cell Stress|language=en|issn=2523-0204}}</ref>

== Awards and recognitions ==
Locasale is a recipient of the [National Institutes of Health](/source/National_Institutes_of_Health) Pathway to Independence Award, the Benjamin Trump Award for Excellence in Cancer Research, and the [American Cancer Society](/source/American_Cancer_Society) Research Scholar Award, and the JH Quastell Lectureship at McGill University.<ref>{{Cite web|url=https://www.science.org/content/webinar/deciphering-cancer-intersection-epigenetics-metabolism-and-tumorigenesis|title=Deciphering cancer: The intersection of epigenetics, metabolism, and tumorigenesis|date=2017-02-21|website=Science {{!}} AAAS|access-date=2019-12-01}}</ref> He serves on the editorial boards for a number of journals including [PLoS Biology](/source/PLOS_Biology), [Oncotarget](/source/Oncotarget), and Cell Stress,<ref>{{Cite web|url=https://journals.plos.org/plosbiology/s/editorial-board|title=PLOS Biology: A Peer-Reviewed Open-Access Journal|website=journals.plos.org|access-date=2019-12-01}}</ref><ref>{{Cite web|url=http://www.oncotarget.com/index.php?journal=oncotarget&page=pages&op=view&path%5B%5D=board|title=Oncotarget {{!}} Editorial Board/Editors|website=www.oncotarget.com|access-date=2020-01-03}}</ref><ref name=":0" /> and has served in advisory roles for a number of companies.  He has also maintained advisory roles at a number of federal, private and international scientific agencies including the National Institutes of Health, the American Cancer Society, and the [Israel Science Foundation](/source/Israel_Science_Foundation).{{Citation needed|date=January 2020}}  He is also widely accomplished in academic mentoring with students and trainees having received the nation's highest honors at the undergraduate, doctoral, and postdoctorals levels<ref>{{Cite web|url=https://www.cancer.gov/grants-training/training/funding/f99|title=NCI F99/K00 Award|date=2015-12-29|website=National Cancer Institute|language=en|access-date=2019-12-18}}</ref><ref>{{Cite web|url=https://today.duke.edu/2019/05/student-honors-and-laurels-2019|title=Student Honors and Laurels for 2019|website=today.duke.edu|language=en|access-date=2019-12-18}}</ref>{{Failed verification|date=January 2020}}.

Locasale has authored over 150 publications in peer-reviewed journals and numerous textbook chapters and patents. In 2019, he was named one of the most influential researchers of the past 10 years by [Web of Science](/source/Web_of_Science).<ref>{{Cite web|url=https://medschool.duke.edu/about-us/news-and-communications/med-school-blog/school-medicine-faculty-recognized-%E2%80%98highly-cited%E2%80%99-list|title=School of Medicine Faculty Recognized on 'Highly Cited' List {{!}} Duke School of Medicine|website=medschool.duke.edu|access-date=2019-12-01|archive-date=2020-04-07|archive-url=https://web.archive.org/web/20200407101314/https://medschool.duke.edu/about-us/news-and-communications/med-school-blog/school-medicine-faculty-recognized-%E2%80%98highly-cited%E2%80%99-list|url-status=dead}}</ref><ref>{{Cite web|url=https://publons.com/awards/highly-cited/2019/|title=Highly Cited Researchers|website=publons.com|access-date=2019-12-01}}</ref><ref>{{Cite web|url=https://today.duke.edu/2019/11/global-list-highly-cited-puts-duke-top-ten|title=Global List of Highly Cited Puts Duke in Top Ten|website=today.duke.edu|language=en|access-date=2019-12-25}}</ref>

== References ==<!-- Inline citations added to your article will automatically display here. See en.wikipedia.org/wiki/WP:REFB for instructions on how to add citations. -->
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{{DEFAULTSORT:Locasale, Jason}}
Category:1981 births
Category:American cancer researchers
Category:Duke University School of Medicine faculty
Category:Massachusetts Institute of Technology alumni
Category:Living people
Category:Rutgers University alumni
Category:21st-century American scientists

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Adapted from the Wikipedia article [Jason Locasale](https://en.wikipedia.org/wiki/Jason_Locasale) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Jason_Locasale?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.