# Interolog

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An '''interolog''' is a conserved interaction between a pair of [proteins](/source/proteins) which have interacting [homologs](/source/Homology_(biology)) in another organism. The term was introduced in a 2000 paper by Walhout et al.<ref>{{Cite journal | last1 = Walhout | first1 = A. J. | last2 = Sordella | first2 = R. | last3 = Lu | first3 = X. | last4 = Hartley | first4 = J. L. | last5 = Temple | first5 = G. F. | last6 = Brasch | first6 = M. A. | last7 = Thierry-Mieg | first7 = N. | last8 = Vidal | first8 = M. | doi = 10.1126/science.287.5450.116 | title = Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development | journal = Science | volume = 287 | issue = 5450 | pages = 116–122 | year = 2000 | pmid =  10615043| bibcode = 2000Sci...287..116W }}</ref><ref>{{Cite journal | doi=10.1101/gr.1774904| pmid=15173116| pmc=419789| title=Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs| journal=Genome Research| volume=14| issue=6| pages=1107–1118| year=2004| last1=Yu| first1=H.| last2=Luscombe| first2=N. M.| last3=Lu| first3=H. X.| last4=Zhu| first4=X.| last5=Xia| first5=Y.| last6=Han| first6=J. D.| last7=Bertin| first7=N.| last8=Chung| first8=S.| last9=Vidal| first9=M.| last10=Gerstein| first10=M.}}</ref>

== Example ==

thumb|right|220px|alt=A

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins.  Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:
*A is a homolog of A'. (Protein homologs have similar [amino acid](/source/amino_acid) sequences and derive from a common ancestral sequence).
*B is a homolog of B'.
*A and B interact.
*A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

==See also==
*[Homology (biology)](/source/Homology_(biology))
*[Systems biology](/source/Systems_biology)
*[Bioinformatics](/source/Bioinformatics)

==References==
{{reflist}}
{{refbegin}}
* {{Cite journal 
| last1 = Yu | first1 = H. 
| last2 = Luscombe | first2 = N. M. 
| last3 = Lu | first3 = H. X. 
| last4 = Zhu | first4 = X. 
| last5 = Xia | first5 = Y. 
| last6 = Han | first6 = J. D. 
| last7 = Bertin | first7 = N. 
| last8 = Chung | first8 = S. 
| last9 = Vidal | first9 = M. 
| last10 = Gerstein | first10 = M. 
| title = Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs 
| doi = 10.1101/gr.1774904 
| journal = Genome Research 
| volume = 14 
| issue = 6 
| pages = 1107–1118 
| year = 2004 
| pmid = 15173116 
| pmc =419789 
}}
* {{Cite journal 
| last1 = Kemmer | first1 = D. 
| last2 = Huang | first2 = Y. 
| last3 = Shah | first3 = S. P. 
| last4 = Lim | first4 = J. 
| last5 = Brumm | first5 = J. 
| last6 = Yuen | first6 = M. M. 
| last7 = Ling | first7 = J. 
| last8 = Xu | first8 = T. 
| last9 = Wasserman | first9 = W. W. 
| last10 = Ouellette | first10 = B. F. 
| title = Ulysses - an application for the projection of molecular interactions across species 
| journal = Genome Biology 
| volume = 6 
| issue = 12 
| pages = R106 
| doi = 10.1186/gb-2005-6-12-r106 
| year = 2005 
| pmid = 16356269 
| pmc =1414088 
| doi-access = free 
}}
* {{Cite journal 
| last1 = Wiles | first1 = A. M. 
| last2 = Doderer | first2 = M. 
| last3 = Ruan | first3 = J. 
| last4 = Gu | first4 = T. T. 
| last5 = Ravi | first5 = D. 
| last6 = Blackman | first6 = B. 
| last7 = Bishop | first7 = A. J. 
| title = Building and analyzing protein interactome networks by cross-species comparisons 
| doi = 10.1186/1752-0509-4-36 
| journal = BMC Systems Biology 
| volume = 4 
| pages = 36 
| year = 2010 
| pmid = 20353594 
| pmc =2859380 
| doi-access = free 
}}
{{refend}}

==External links==
* [http://interactome.org Interactome.org] {{Webarchive|url=https://web.archive.org/web/20080820063335/http://interactome.org/ |date=2008-08-20 }}: Interactome portal site.
* {{usurped|1=[https://web.archive.org/web/20080706140930/http://interactomics.org/ Interactomics.org]}}: Interactomics portal site.
* [http://www.interologfinder.org]: Cross-species interaction prediction site.

Category:Protein complexes
Category:Bioinformatics

{{bioinformatics-stub}}

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Adapted from the Wikipedia article [Interolog](https://en.wikipedia.org/wiki/Interolog) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Interolog?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.