# IU1
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> Markdown URL: https://mediated.wiki/source/IU1.md
> Source: https://en.wikipedia.org/wiki/IU1
> Source revision: 1330313444
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{{Drugbox
| IUPAC_name = 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
| image = IU1_structure.png
| image_class = skin-invert-image
| width = 240
| tradename =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability =
| protein_bound =
| excretion =
| CAS_number = 314245-33-5
| UNII =
| PubChem = 675434
| IUPHAR_ligand =
| DrugBank =
| ChemSpiderID =
| ChEBI = 232499
| ChEMBL = 1410015
| StdInChI = 1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
| StdInChIKey = JUWDSDKJBMFLHE-UHFFFAOYSA-N
| C=18 | H=21 | F=1 | N=2 | O=1
| smiles = CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
}}
'''IU1''' is a drug used in scientific research which acts as a selective inhibitor of the ubiquitin-specific processing protease [enzyme](/source/enzyme) [USP14](/source/USP14).[{{cite journal | vauthors = Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D | title = Enhancement of proteasome activity by a small-molecule inhibitor of USP14 | journal = Nature | volume = 467 | issue = 7312 | pages = 179–84 | date = September 2010 | pmid = 20829789 | pmc = 2939003 | doi = 10.1038/nature09299 | bibcode = 2010Natur.467..179L }}] It is of interest in anti-cancer and antiviral research and also as a potential anti-aging drug. Numerous derivatives of IU1 have been developed with up to 10x the potency of IU1 as USP14 inhibitors,[{{cite journal | vauthors = Wang Y, Jiang Y, Ding S, Li J, Song N, Ren Y, Hong D, Wu C, Li B, Wang F, He W, Wang J, Mei Z | title = Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade | journal = Cell Research | volume = 28 | issue = 12 | pages = 1186–1194 | date = December 2018 | pmid = 30254335 | pmc = 6274642 | doi = 10.1038/s41422-018-0091-x | url = }}][{{cite journal | vauthors = Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D | title = An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons | journal = The Journal of Biological Chemistry | volume = 292 | issue = 47 | pages = 19209–19225 | date = November 2017 | pmid = 28972160 | pmc = 5702663 | doi = 10.1074/jbc.M117.815126 | doi-access = free | url = }}] but IU1 remains the most widely used compound in research in this area.[{{cite journal | vauthors = Nag DK, Finley D | title = A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication | journal = Virus Research | volume = 165 | issue = 1 | pages = 103–106 | date = April 2012 | pmid = 22306365 | doi = 10.1016/j.virusres.2012.01.009 }}][{{cite journal | vauthors = Moon S, Muniyappan S, Lee SB, Lee BH | title = Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases | journal = International Journal of Molecular Sciences | volume = 22 | issue = 12 | date = June 2021 | page = 6213 | pmid = 34207520 | doi = 10.3390/ijms22126213 | pmc = 8226605 | doi-access = free }}][{{cite journal | vauthors = Wang F, Ning S, Yu B, Wang Y | title = USP14: Structure, Function, and Target Inhibition | journal = Frontiers in Pharmacology | date = 2022 | volume = 12 | article-number = 801328 | pmid = 35069211 | doi = 10.3389/fphar.2021.801328 | pmc = 8766727 | doi-access = free }}][{{cite journal | vauthors = Pan J, Zhao J, Feng L, Xu X, He Z, Liang W | title = Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury | journal = Cell Biochemistry and Biophysics | volume = 81 | issue = 1 | pages = 87–96 | date = March 2023 | pmid = 36255562 | doi = 10.1007/s12013-022-01107-y }}][{{cite journal | vauthors = Hou W, Yao J, Liu J, Lin X, Wei J, Yin X, Huang H, Chen X, Yang GY, He X | title = USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice | journal = CNS Neuroscience & Therapeutics | volume = 29 | issue = 11 | pages = 3612–3623 | date = November 2023 | pmid = 37269080 | doi = 10.1111/cns.14292 | pmc = 10580339 }}][{{cite journal | vauthors = Lim JJ, Noh S, Kang W, Hyun B, Lee BH, Hyun S | title = Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner | journal = Autophagy | volume = 20 | issue = 12 | pages = 2752–2768 | date = December 2024 | pmid = 39113571 | doi = 10.1080/15548627.2024.2389607 | pmc = 11587835 }}][{{cite journal | vauthors = Zhou X, Xia Q, Wang B, Li J, Liu B, Wang S, Huang M, Zhong R, Cheng SY, Wang X, Jiang X, Huang T | title = USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5 | journal = Theranostics | date = 2025 | volume = 15 | issue = 6 | pages = 2293–2314 | pmid = 39990235 | doi = 10.7150/thno.103629 | pmc = 11840735 }}]
== References ==
{{reflist}}
{{nervous-system-drug-stub}}
Category:Pyrroles
Category:4-Fluorophenyl compounds
Category:Pyrrolidines
Category:Ketones
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Adapted from the Wikipedia article [IU1](https://en.wikipedia.org/wiki/IU1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/IU1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.