# ITPKB

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> Source: https://en.wikipedia.org/wiki/ITPKB
> Source revision: 1300693001
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Inositol-trisphosphate 3-kinase B''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''ITPKB'' [gene](/source/gene).<ref name="pmid1654894">{{cite journal |vauthors=Takazawa K, Perret J, Dumont JE, Erneux C | title = Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme | journal = Biochem J | volume = 278 | issue =  3| pages = 883–6 |date=Oct 1991 | pmid = 1654894 | pmc = 1151429 | doi =  10.1042/bj2780883}}</ref><ref name="pmid1330886">{{cite journal |vauthors=Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG | title = Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization | journal = Genomics | volume = 14 | issue = 2 | pages = 546–7 |date=Dec 1992 | pmid = 1330886 | doi =10.1016/S0888-7543(05)80265-4  }}</ref>

== Function ==

The protein encoded by the ITPKB gene is one of 3 isoforms of [Inositol-trisphosphate 3-kinase](/source/Inositol-trisphosphate_3-kinase) expressed in humans. ITPKB protein regulates [inositol phosphate](/source/inositol_phosphate) metabolism by [phosphorylation](/source/phosphorylation) of second messenger [inositol 1,4,5-trisphosphate](/source/inositol_1%2C4%2C5-trisphosphate), which releases calcium from intracellular store in the [endoplasmic reticulum](/source/endoplasmic_reticulum) by gating the [inositol trisphosphate receptor](/source/inositol_trisphosphate_receptor). ITPKB produces Ins(1,3,4,5)P<small>4</small>, which does ''not'' gate the [inositol trisphosphate receptor](/source/inositol_trisphosphate_receptor). The enzyme specifically phosphorylates the 1,4,5 isomer of [IP<small>3</small>](/source/inositol_1%2C4%2C5-trisphosphate). The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.<ref>{{cite web | title = Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3707}}</ref>  Itpkb regulates immune cell function and is required for T and B cell development.<ref>{{cite journal | pmid = 20336153 | doi=10.1038/nri2745 | volume=10 | issue=4 | title=Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate | pmc=2922113 |date=April 2010 | journal=Nat. Rev. Immunol. | pages=257–71 |vauthors=Sauer K, Cooke MP }}</ref>

==References==
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==Further reading==
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*{{cite journal   |vauthors=Szlufcik K, Missiaen L, Parys JB, etal |title=Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences. |journal=Biol. Cell |volume=98 |issue= 1 |pages= 1–14 |year= 2006 |pmid= 16354157 |doi= 10.1042/BC20050031 |s2cid=36990427 |doi-access=  }}
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{{PDB Gallery|geneid=3707}}

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Adapted from the Wikipedia article [ITPKB](https://en.wikipedia.org/wiki/ITPKB) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ITPKB?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.