# IRF2BP2

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**Interferon regulatory factor 2 binding protein 2** is a [protein](/source/Protein) that in humans is encoded by the IRF2BP2 [gene](/source/Gene). [1]

## Function

This gene encodes an [interferon regulatory factor-2](/source/Interferon_regulatory_factor-2) (IRF2) binding protein that interacts with the [C-terminal](/source/C-terminal) transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

## References

1. ["Entrez Gene: Interferon regulatory factor 2 binding protein 2"](https://www.ncbi.nlm.nih.gov/gene/359948). Retrieved 2017-01-06.

## Further reading

- Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". *Nucleic Acids Res.*. **31** (12): 3016–26. [doi:10.1093/nar/gkg431](https://doi.org/10.1093/nar/gkg431). [PMC 162335](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC162335). [PMID 12799427](https://pubmed.ncbi.nlm.nih.gov/12799427)
- Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". *Cancer Res.*. **69** (4): 1375–82. [doi:10.1158/0008-5472.CAN-08-2896](https://doi.org/10.1158/0008-5472.CAN-08-2896). [PMC 4264605](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264605). [PMID 19190336](https://pubmed.ncbi.nlm.nih.gov/19190336)
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". *FASEB J.*. **24** (12): 4825–34. [doi:10.1096/fj.10-167049](https://doi.org/10.1096/fj.10-167049). [PMID 20702774](https://pubmed.ncbi.nlm.nih.gov/20702774). [S2CID 35708173](https://api.semanticscholar.org/CorpusID:35708173)
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". *FASEB J.*. **24** (12): 4825–34. [doi:10.1096/fj.10-167049](https://doi.org/10.1096/fj.10-167049). [PMID 20702774](https://pubmed.ncbi.nlm.nih.gov/20702774). [S2CID 35708173](https://api.semanticscholar.org/CorpusID:35708173)
- Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". *Mol. Cell. Biol.*. **31** (14): 2889–901. [doi:10.1128/MCB.00974-10](https://doi.org/10.1128/MCB.00974-10). [PMC 3133407](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133407). [PMID 21576369](https://pubmed.ncbi.nlm.nih.gov/21576369)
- Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". *PLOS ONE*. **6** (8). [Bibcode:2011PLoSO...624100T](https://ui.adsabs.harvard.edu/abs/2011PLoSO...624100T). [doi:10.1371/journal.pone.0024100](https://doi.org/10.1371/journal.pone.0024100). [PMC 3162591](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162591). [PMID 21887377](https://pubmed.ncbi.nlm.nih.gov/21887377)
- Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". *PLOS ONE*. **7** (11). [Bibcode:2012PLoSO...749705N](https://ui.adsabs.harvard.edu/abs/2012PLoSO...749705N). [doi:10.1371/journal.pone.0049705](https://doi.org/10.1371/journal.pone.0049705). [PMC 3504151](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504151). [PMID 23185413](https://pubmed.ncbi.nlm.nih.gov/23185413)

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Adapted from the Wikipedia article [IRF2BP2](https://en.wikipedia.org/wiki/IRF2BP2) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/IRF2BP2?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.