# IFIT3

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Protein-coding gene in the species Homo sapiens

IFIT3 Identifiers Aliases IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3 External IDs OMIM: 604650; MGI: 1101055; HomoloGene: 1189; GeneCards: IFIT3; OMA:IFIT3 - orthologs Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,327,307 bp[1] End 89,377,473 bp[1] Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,560,931 bp[2] End 34,566,131 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion jejunal mucosa pericardium lower lobe of lung spinal ganglia human penis palpebral conjunctiva monocyte endothelial cell synovial joint Top expressed in right kidney granulocyte human kidney thymus jejunum lung colon adrenal gland spleen embryo More reference expression data BioGPS More reference expression data Gene ontology Molecular function identical protein binding protein binding molecular function RNA binding Cellular component cytoplasm mitochondrion cytosol Biological process immune system process response to virus innate immune response negative regulation of apoptotic process defense response to virus type I interferon signaling pathway negative regulation of cell population proliferation cellular response to interferon-alpha response to bacterium cellular response to interferon-beta Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 3437 15959 Ensembl ENSG00000119917 ENSMUSG00000074896 UniProt O14879 Q64345 RefSeq (mRNA) NM_001549 NM_001031683 NM_001289758 NM_001289759 NM_010501 RefSeq (protein) NP_001026853 NP_001276687 NP_001276688 NP_001540 NP_034631 Location (UCSC) Chr 10: 89.33 – 89.38 Mb Chr 19: 34.56 – 34.57 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Interferon-induced protein with tetratricopeptide repeats 3**, also known as interferon-stimulated gene 49 (ISG49),[5] is a [protein](/source/Protein) that in humans is encoded by the *IFIT3* [gene](/source/Gene).[5][6][7][8] It plays a part in the [innate immune response](/source/Innate_immune_response) to [viruses](/source/Virus) in response to [type I interferon](/source/Type_I_interferon) signaling.[5]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000119917](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000119917) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000074896](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000074896) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=3437). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=15959). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. ^ [***a***](#cite_ref-Fensterl2012_5-0) [***b***](#cite_ref-Fensterl2012_5-1) [***c***](#cite_ref-Fensterl2012_5-2) Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, et al. (2012). ["Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355090). *PLOS Pathogens*. **8** (5) e1002712. [doi](/source/Doi_(identifier)):[10.1371/journal.ppat.1002712](https://doi.org/10.1371%2Fjournal.ppat.1002712). [PMC](/source/PMC_(identifier)) [3355090](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355090). [PMID](/source/PMID_(identifier)) [22615570](https://pubmed.ncbi.nlm.nih.gov/22615570).

1. **[^](#cite_ref-pmid9828129_6-0)** de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (December 1998). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". *Genomics*. **54** (2): 267–277. [doi](/source/Doi_(identifier)):[10.1006/geno.1998.5555](https://doi.org/10.1006%2Fgeno.1998.5555). [PMID](/source/PMID_(identifier)) [9828129](https://pubmed.ncbi.nlm.nih.gov/9828129).

1. **[^](#cite_ref-pmid9391139_7-0)** Zhu H, Cong JP, Shenk T (December 1997). ["Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28419). *Proceedings of the National Academy of Sciences of the United States of America*. **94** (25): 13985–13990. [Bibcode](/source/Bibcode_(identifier)):[1997PNAS...9413985Z](https://ui.adsabs.harvard.edu/abs/1997PNAS...9413985Z). [doi](/source/Doi_(identifier)):[10.1073/pnas.94.25.13985](https://doi.org/10.1073%2Fpnas.94.25.13985). [PMC](/source/PMC_(identifier)) [28419](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28419). [PMID](/source/PMID_(identifier)) [9391139](https://pubmed.ncbi.nlm.nih.gov/9391139).

1. **[^](#cite_ref-entrez_8-0)** ["Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3437).

## Further reading

- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". *Nature Biotechnology*. **24** (10): 1285–1292. [doi](/source/Doi_(identifier)):[10.1038/nbt1240](https://doi.org/10.1038%2Fnbt1240). [PMID](/source/PMID_(identifier)) [16964243](https://pubmed.ncbi.nlm.nih.gov/16964243). [S2CID](/source/S2CID_(identifier)) [14294292](https://api.semanticscholar.org/CorpusID:14294292).

- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–1178. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". *Experimental Cell Research*. **289** (2): 211–221. [doi](/source/Doi_(identifier)):[10.1016/S0014-4827(03)00261-1](https://doi.org/10.1016%2FS0014-4827%2803%2900261-1). [PMID](/source/PMID_(identifier)) [14499622](https://pubmed.ncbi.nlm.nih.gov/14499622).

- Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". *Nature Medicine*. **9** (2): 191–197. [doi](/source/Doi_(identifier)):[10.1038/nm822](https://doi.org/10.1038%2Fnm822). [PMID](/source/PMID_(identifier)) [12539042](https://pubmed.ncbi.nlm.nih.gov/12539042). [S2CID](/source/S2CID_(identifier)) [26145639](https://api.semanticscholar.org/CorpusID:26145639).

- Yu M, Tong JH, Mao M, Kan LX, Liu MM, Sun YW, et al. (July 1997). ["Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23834). *Proceedings of the National Academy of Sciences of the United States of America*. **94** (14): 7406–7411. [Bibcode](/source/Bibcode_(identifier)):[1997PNAS...94.7406Y](https://ui.adsabs.harvard.edu/abs/1997PNAS...94.7406Y). [doi](/source/Doi_(identifier)):[10.1073/pnas.94.14.7406](https://doi.org/10.1073%2Fpnas.94.14.7406). [PMC](/source/PMC_(identifier)) [23834](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23834). [PMID](/source/PMID_(identifier)) [9207104](https://pubmed.ncbi.nlm.nih.gov/9207104).

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