# Hyperproteinemia > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Hyperproteinemia > Markdown URL: https://mediated.wiki/source/Hyperproteinemia.md > Source: https://en.wikipedia.org/wiki/Hyperproteinemia > Source revision: 1293648222 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|High protein concentration in the blood}} {{Infobox medical condition | name = Hyperproteinemia | synonyms = High blood protein | image = Serum protein electrophoresis normal results.jpg | alt = | caption = [Serum protein electrophoresis](/source/Serum_protein_electrophoresis) normal results (study performed at a hospital laboratory). | pronounce = | synonym = | field = [Hematology](/source/Hematology) | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} '''Hyperproteinemia''' is the state of having overly high levels of protein in the blood. This can occur due to [monoclonal gammopathies](/source/monoclonal_gammopathies) such as [multiple myeloma](/source/multiple_myeloma) and after [intravenous immunoglobulin](/source/intravenous_immunoglobulin) has been given. It can result in a falsely low appearing sodium level ([hyponatremia](/source/hyponatremia)).{{cite journal|last1=Filippatos|first1=TD|last2=Liamis|first2=G |last3=Christopoulou |first3=F |last4=Elisaf |first4=MS |title=Ten common pitfalls in the evaluation of patients with hyponatremia.|journal=European Journal of Internal Medicine|date=April 2016|volume=29|pages=22–5|pmid=26706473|doi=10.1016/j.ejim.2015.11.022|doi-access=free}} ==Causes== Increases in certain proteins that are typically present in relatively low concentrations, such as [acute phase reactants](/source/Acute-phase_protein) and polyclonal [immunoglobulins](/source/immunoglobulins) caused by [inflammation](/source/inflammation), late-stage [liver disease](/source/liver_disease), and [infections](/source/Infection), can result in mild hyperproteinemia. Normal total protein levels are not sufficient to rule out [multiple myeloma](/source/multiple_myeloma) or other malignant [paraproteinemias](/source/paraproteinemias), but they may also be the cause of moderate-to-marked hyperproteinemia. To determine the reason behind the elevated serum total protein, a [serum protein electrophoresis](/source/serum_protein_electrophoresis) should be carried out.{{cite web | title=Protein, Total, Serum | website=Endocrinology Catalog |url=https://endocrinology.testcatalog.org/show/TP | access-date=December 28, 2023}} The plasma protein level may increase due to dehydration from blood loss of fluids (severe vomiting and diarrhea).{{Citation needed|date=June 2025}} 1. Physiological causes:{{Citation needed|date=June 2025}} * Standing position * Vigorous exercise * Excessive stasis while withdrawing blood 2. Pathological causes:{{Citation needed|date=June 2025}} * Infective disease like tuberculosis * [Multiple myeloma](/source/Multiple_myeloma) Reduced production ([hypogammaglobulinemia](/source/hypogammaglobulinemia)), as well as increased protein loss ([nephrotic syndrome](/source/nephrotic_syndrome), [protein-losing enteropathy](/source/Protein_losing_enteropathy)), can cause hypoproteinemia. To determine the reason behind the lower serum total protein, a [serum protein electrophoresis](/source/serum_protein_electrophoresis) ought to be carried out. [Urine protein electrophoresis](/source/Urine_protein_electrophoresis) needs to be carried out if a [nephrotic](/source/Nephrotic_syndrome) pattern is found. ==See also== * [Hypoproteinemia](/source/Hypoproteinemia) * [Plasma protein](/source/Plasma_protein) ==References== {{reflist}} ==Further reading== * {{cite journal | last1=Wang | first1=Guang | last2=Wang | first2=Yong-Feng | last3=Li | first3=Jiang-Lan | last4=Peng | first4=Ru-Ji | last5=Liang | first5=Xin-Yin | last6=Chen | first6=Xue-Dong | last7=Jiang | first7=Gui-Hua | last8=Shi | first8=Jin-Fang | last9=Si-Ma | first9=Yang-Hu | last10=Xu | first10=Shi-Qing | title=Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model | journal=Zoological Research | publisher=Editorial Office of Zoological Research, Kunming Institute of Zoology, The Chinese Academy of Sciences | volume=43 | issue=3 | date=May 5, 2022 | pages=301–318 | pmid=35312240 | doi=10.24272/j.issn.2095-8137.2021.397 | ref=none | doi-access=free| pmc=9113973 }} * {{cite journal |last1=Leonard |first1=Cardon |last2=Donald H |first2=Atlas |title=Incidence and causes of hyperproteinemia a study of 4,390 cases |journal=Arch Intern Med |date=1943 |volume=71 |issue=3 |pages=377–390 |doi=10.1001/archinte.1943.00210030078007 |url=https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/549218 |access-date=28 December 2023 | ref=none |url-access=subscription }} ==External links== * [https://my.clevelandclinic.org/health/symptoms/21025-high-blood-protein-hyperproteinemia Cleveland Clinic] * [https://www.mayoclinic.org/symptoms/high-blood-protein/basics/definition/sym-20050599 Mayo Clinic] {{Medical resources | ICD11 = {{ICD11|5D0Y}} | ICD10 = {{ICD10|E88.0}} | ICD10CM = {{ICD10CM|E88.09}} | ICD9 = {{ICD9|273.8}} | ICDO = | OMIM = | MeshID = | DiseasesDB = | SNOMED CT = 37064009 | Curlie = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | PatientUK = | NCI = | GeneReviewsNBK = | GeneReviewsName = | NORD = | GARDNum = | GARDName = | RP = | AO = | WO = | OrthoInfo = | Orphanet = | Scholia = Q3144191 | OB = }} Category:Abnormal clinical and laboratory findings for blood --- Adapted from the Wikipedia article [Hyperproteinemia](https://en.wikipedia.org/wiki/Hyperproteinemia) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Hyperproteinemia?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.