# Hyperchlorhydria

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> Source: https://en.wikipedia.org/wiki/Hyperchlorhydria
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**Hyperchlorhydria**, sometimes called **chlorhydria**, **sour stomach** or **acid stomach**,[1][2] refers to the state in the [stomach](/source/Stomach) where [gastric acid](/source/Gastric_acid) levels are higher than the [reference range](/source/Reference_range). The [combining forms](/source/Classical_compound) of the name (*[chlor-](https://en.wiktionary.org/wiki/chloro-)* + *[hydr-](https://en.wiktionary.org/wiki/hydro-)*), referring to [chlorine](/source/Chlorine) and [hydrogen](/source/Hydrogen), are the same as those in the name of [hydrochloric acid](/source/Hydrochloric_acid), which is the [active constituent](/source/Active_ingredient) of gastric acid.

In humans, the normal [pH](/source/PH) is around 1 to 3, which varies throughout the day. The highest basal secretion levels are in the late evening (around 12 A.M. to 3 A.M.). Hyperchlorhydria is usually defined as having a pH less than 2.

In [Zollinger–Ellison syndrome](/source/Zollinger%E2%80%93Ellison_syndrome) [gastrin](/source/Gastrin) levels are increased, leading to excess gastric acid production, which can cause [gastric ulcers](/source/Gastric_ulcer).[3] [Hypercalcemia](/source/Hypercalcemia) also increases gastrin and gastric acid and can cause ulcers.[citation needed]

## See also

- [Achlorhydria](/source/Achlorhydria)
- [Hypochlorhydria](/source/Hypochlorhydria)

## References

1. ["Dorland's Illustrated Medical Dictionary"](https://web.archive.org/web/20140111192614/http://dorlands.com/). Elsevier. Archived from [the original](http://dorlands.com/) on 11 January 2014. Retrieved 9 July 2018.

1. ["Medical Dictionary for Regulatory Activities - Sour stomach - Classes - NCBO BioPortal"](https://web.archive.org/web/20180709215644/http://bioportal.bioontology.org/ontologies/MEDDRA?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMEDDRA%2F10041373#details/). *Bioportal.bioontology.org*. Archived from [the original](http://bioportal.bioontology.org/ontologies/MEDDRA?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMEDDRA%2F10041373#details/) on 9 July 2018. Retrieved 9 July 2018.

1. ["Zollinger-Ellison syndrome"](https://www.mayoclinic.org/diseases-conditions/zollinger-ellison-syndrome/symptoms-causes/syc-20379042). Retrieved 10 January 2025.

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Adapted from the Wikipedia article [Hyperchlorhydria](https://en.wikipedia.org/wiki/Hyperchlorhydria) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Hyperchlorhydria?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.