# Homeostatic capacity

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Capability of systems to maintain homeostasis

**Homeostatic capacity** refers to the capability of systems to self-stabilize in response to external forces or [stressors](/source/Stress_(psychological)), or more simply the capability of systems to maintain [homeostasis](/source/Homeostasis).[1][2] For living [organisms](/source/Organisms), it is life's foundational trait, consisting of a hierarchy and network of traits endowed by nature and shaped by natural selection. Homeostatic capacity comprises a [multidimensional network](/source/Multidimensional_network) of traits and operates at all scales of [biology](/source/Biology) systems levels including molecular, cellular, physiological, and organismal.

## Human homeostatic capacity

Main article: [Human homeostasis](/source/Human_homeostasis)

In the context of human beings, homeostatic capacity refers to the inherent ability of the body to self-stabilize in response to external and internal [stimuli](/source/Stimulus_(physiology)). Homeostatic capacity of the human body erodes with age.[3][4][5]

## Homeostatic capacity and aging

A hypothesis proffered by the proponents of the Palo Alto Longevity Prize is that the array of ailments associated with aging may be epiphenomena of eroding homeostatic capacity and the process of [aging](/source/Aging) may be halted or reversed by restoring homeostatic capacity to that of a healthy young adult.[6][7][8][9][10]

## See also

- [Senescence](/source/Senescence)

## References

1. **[^](#cite_ref-1)** [Anthony Joonkyoo Yun, MD](/source/Joon_Yun) (2014). *Hiding in Plain Sight: Essays by Joon Yun, MD, Second Edition*. p. 130. [ISBN](/source/ISBN_(identifier)) [9781312492028](https://en.wikipedia.org/wiki/Special:BookSources/9781312492028).

1. **[^](#cite_ref-2)** ["After the last death: Doctors, academics debate the possibility, value of a 150-year lifespan"](http://www.paloaltoonline.com/news/2015/01/09/after-the-last-death-doctors-academics-debate-the-possibility-value-of-a-150-year-lifespan). Palo Alto Online. January 9, 2015. Retrieved January 13, 2015.

1. **[^](#cite_ref-3)** Novoseltsev VN, Novoseltseva J, Yashin AI (2001). "A homeostatic model of oxidative damage explains paradoxes observed in earlier aging experiments: a fusion and extension of older theories of aging". *Biogerontology*. **2** (2): 127–38. [doi](/source/Doi_(identifier)):[10.1023/a:1011511100472](https://doi.org/10.1023%2Fa%3A1011511100472). [PMID](/source/PMID_(identifier)) [11708379](https://pubmed.ncbi.nlm.nih.gov/11708379). [S2CID](/source/S2CID_(identifier)) [6542650](https://api.semanticscholar.org/CorpusID:6542650).

1. **[^](#cite_ref-4)** Rolls BJ, Phillips PA (March 1990). "Aging and disturbances of thirst and fluid balance". *Nutr Rev*. **48** (3): 137–44. [doi](/source/Doi_(identifier)):[10.1111/j.1753-4887.1990.tb02915.x](https://doi.org/10.1111%2Fj.1753-4887.1990.tb02915.x). [PMID](/source/PMID_(identifier)) [2406645](https://pubmed.ncbi.nlm.nih.gov/2406645).

1. **[^](#cite_ref-5)** Phillips, Paddy A.; Hodsman, G. Peter; Johnston, Colin I. (January 1991). "Neuroendocrine mechanisms and cardiovascular homeostasis in the elderly". *Cardiovascular Drugs and Therapy*. **4** (S6): 1209–1213. [doi](/source/Doi_(identifier)):[10.1007/BF00114221](https://doi.org/10.1007%2FBF00114221). [PMID](/source/PMID_(identifier)) [2009244](https://pubmed.ncbi.nlm.nih.gov/2009244). [S2CID](/source/S2CID_(identifier)) [32343396](https://api.semanticscholar.org/CorpusID:32343396).

1. **[^](#cite_ref-6)** ["FAQ – Palo Alto Longevity Prize"](https://web.archive.org/web/20141006100629/http://paloaltoprize.com/faq/). Palo Alto Longevity Prize. Archived from [the original](http://paloaltoprize.com/faq/) on October 6, 2014. Retrieved October 1, 2014.

1. **[^](#cite_ref-7)** [Ashlee Vance](/source/Ashlee_Vance) (September 9, 2014). ["Silicon Valley Investor Backs $1 Million Prize to End Death"](http://www.businessweek.com/articles/2014-09-09/silicon-valley-investor-backs-1-million-longevity-prize). [Bloomberg Businessweek](/source/Bloomberg_Businessweek). Retrieved October 1, 2014.

1. **[^](#cite_ref-8)** ["$1 Million Longevity Prize Seeks To "Hack The Aging Code""](https://finance.yahoo.com/news/1-million-longevity-prize-seeks-133000078.html) (Press release). [Yahoo! Finance](/source/Yahoo!_Finance). September 9, 2014. Retrieved October 1, 2014.

1. **[^](#cite_ref-9)** Aaron Kinney (September 14, 2014). ["Silicon Valley launches another bid to 'hack' aging, cheat death"](http://www.mercurynews.com/business/ci_26533364/silicon-valley-launches-another-bid-hack-aging-cheat). *[San Jose Mercury News](/source/San_Jose_Mercury_News)*. Retrieved October 1, 2014.

1. **[^](#cite_ref-10)** Victoria Thorp (November 23, 2014). ["The Palo Alto Prize: A 'Moonshot' at Increasing Longevity"](https://web.archive.org/web/20141206054958/http://paloaltopulse.net/2014/11/23/the-palo-alto-prize-a-moonshot-at-increasing-longevity/). Palo Alto Pulse. Archived from [the original](http://paloaltopulse.net/2014/11/23/the-palo-alto-prize-a-moonshot-at-increasing-longevity/) on December 6, 2014. Retrieved December 8, 2014.

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Adapted from the Wikipedia article [Homeostatic capacity](https://en.wikipedia.org/wiki/Homeostatic_capacity) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Homeostatic_capacity?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.