# HIST1H3B
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox_gene}}
'''Histone H3.1''' is a [protein](/source/protein) that in humans is encoded by the ''H3C2'' [gene](/source/gene).[{{cite journal |vauthors=Zhong R, Roeder RG, Heintz N | title = The primary structure and expression of four cloned human histone genes | journal = Nucleic Acids Res | volume = 11 | issue = 21 | pages = 7409–25 |date=Jan 1984 | pmid = 6647026 | pmc = 326492 | doi =10.1093/nar/11.21.7409 }}][{{cite journal |vauthors=Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D | title = Human histone gene organization: nonregular arrangement within a large cluster | journal = Genomics | volume = 40 | issue = 2 | pages = 314–22 |date=Apr 1997 | pmid = 9119399 | doi = 10.1006/geno.1996.4592 }}][{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | doi =10.1016/S0888-7543(02)96850-3 }}]
[Histones](/source/Histone) are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[{{cite web | title = Entrez Gene: HIST1H3B histone cluster 1, H3b| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8358}}]
==References==
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==Further reading==
{{refbegin | 2}}
*{{cite journal | author=Albig W |title=Isolation and characterization of two human H1 histone genes within clusters of core histone genes |journal=Genomics |volume=10 |issue= 4 |pages= 940–8 |year= 1991 |pmid= 1916825 |doi=10.1016/0888-7543(91)90183-F | author2=Kardalinou E | author3=Drabent B | last4=Zimmer | first4=Andreas | last5=Doenecke | first5=Detlef }}
*{{cite journal | author=Marashi F |title=Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences |journal=Biochem. Cell Biol. |volume=64 |issue= 4 |pages= 277–89 |year= 1986 |pmid= 3013246 |doi=10.1139/o86-039 | author2=Helms S | author3=Shiels A | last4=Silverstein | first4=Saul | last5=Greenspan | first5=Daniel S. | last6=Stein | first6=Gary | last7=Stein | first7=Janet }}
*{{cite journal |vauthors=Ohe Y, Iwai K |title=Human spleen histone H3. Isolation and amino acid sequence |journal=J. Biochem. |volume=90 |issue= 4 |pages= 1205–11 |year= 1982 |pmid= 7309716 |doi= 10.1093/oxfordjournals.jbchem.a133573|doi-access=free }}
*{{cite journal |vauthors=Kardalinou E, Eick S, Albig W, Doenecke D |title=Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones |journal=J. Cell. Biochem. |volume=52 |issue= 4 |pages= 375–83 |year= 1993 |pmid= 8227173 |doi= 10.1002/jcb.240520402 |s2cid=42454232 }}
*{{cite journal |vauthors=Albig W, Meergans T, Doenecke D |title=Characterization of the H1.5 gene completes the set of human H1 subtype genes |journal=Gene |volume=184 |issue= 2 |pages= 141–8 |year= 1997 |pmid= 9031620 |doi=10.1016/S0378-1119(96)00582-3 }}
*{{cite journal |vauthors=Albig W, Doenecke D |title=The human histone gene cluster at the D6S105 locus |journal=Hum. Genet. |volume=101 |issue= 3 |pages= 284–94 |year= 1998 |pmid= 9439656 |doi=10.1007/s004390050630 |s2cid=38539096 }}
*{{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi= 10.1128/mcb.18.5.2535| pmc=110633 }}
*{{cite journal | author=Goto H |title=Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25543–25549 |year= 1999 |pmid= 10464286 |doi=10.1074/jbc.274.36.25543 | author2=Tomono Y | author3=Ajiro K | last4=Kosako | first4=H | last5=Fujita | first5=M | last6=Sakurai | first6=M | last7=Okawa | first7=K | last8=Iwamatsu | first8=A | last9=Okigaki | first9=T | doi-access=free }}
*{{cite journal | author=Hsu JY |title=Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes |journal=Cell |volume=102 |issue= 3 |pages= 279–91 |year= 2000 |pmid= 10975519 |doi=10.1016/S0092-8674(00)00034-9 | author2=Sun ZW | author3=Li X | last4=Reuben | first4=Melanie | last5=Tatchell | first5=Kelly | last6=Bishop | first6=Douglas K | last7=Grushcow | first7=Jeremy M | last8=Brame | first8=Cynthia J | last9=Caldwell | first9=Jennifer A |s2cid=16057773 | doi-access=free }}
*{{cite journal | author=Deng L |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–295 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 | author2=de la Fuente C | author3=Fu P | last4=Wang | first4=L | last5=Donnelly | first5=R | last6=Wade | first6=JD | last7=Lambert | first7=P | last8=Li | first8=H | last9=Lee | first9=CG |s2cid=20145752 | doi-access=free }}
*{{cite journal | author=Lachner M |title=Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins |journal=Nature |volume=410 |issue= 6824 |pages= 116–20 |year= 2001 |pmid= 11242053 |doi= 10.1038/35065132 | author2=O'Carroll D | author3=Rea S | last4=Mechtler | first4=Karl | last5=Jenuwein | first5=Thomas |bibcode=2001Natur.410..116L |s2cid=4331863 }}
*{{cite journal | author=Deng L |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 | author2=Wang D | author3=de la Fuente C | last4=Wang | first4=L | last5=Li | first5=H | last6=Lee | first6=CG | last7=Donnelly | first7=R | last8=Wade | first8=JD | last9=Lambert | first9=P | doi-access=free }}
*{{cite journal | author=Yang L |title=Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor |journal=Oncogene |volume=21 |issue= 1 |pages= 148–52 |year= 2002 |pmid= 11791185 |doi= 10.1038/sj.onc.1204998 | author2=Xia L | author3=Wu DY | last4=Wang | first4=Hengbin | last5=Chansky | first5=Howard A | last6=Schubach | first6=William H | last7=Hickstein | first7=Dennis D | last8=Zhang | first8=Yi |s2cid=10912876 | doi-access= }}
*{{cite journal |vauthors=Goto H, Yasui Y, Nigg EA, Inagaki M |title=Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation |journal=Genes Cells |volume=7 |issue= 1 |pages= 11–7 |year= 2002 |pmid= 11856369 |doi=10.1046/j.1356-9597.2001.00498.x |s2cid=23717416 }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal |vauthors=Preuss U, Landsberg G, Scheidtmann KH |title=Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase |journal=Nucleic Acids Res. |volume=31 |issue= 3 |pages= 878–85 |year= 2003 |pmid= 12560483 |doi=10.1093/nar/gkg176 | pmc=149197 }}
*{{cite journal | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–811 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 | author2=Palmer SA | author3=Sims SK | last4=Edwards | first4=C. A. | last5=Ashurst | first5=J. L. | last6=Wilming | first6=L. | last7=Jones | first7=M. C. | last8=Horton | first8=R. | last9=Hunt | first9=S. E. |bibcode=2003Natur.425..805M | doi-access=free }}
{{refend}}
== External links ==
* {{PDBe-KB2|P68431|Histone H3.1}}
{{PDB Gallery|geneid=8358}}
{{protein-stub}}
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Adapted from the Wikipedia article [HIST1H3B](https://en.wikipedia.org/wiki/HIST1H3B) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/HIST1H3B?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.