# HHIP

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Protein-coding gene in the species Homo sapiens

HHIP Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5 Identifiers Aliases HHIP, HIP, hedgehog interacting protein External IDs OMIM: 606178; MGI: 1341847; HomoloGene: 32469; GeneCards: HHIP; OMA:HHIP - orthologs Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 144,646,156 bp[1] End 144,745,271 bp[1] Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 37.95 cM Start 80,692,480 bp[2] End 80,784,635 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell globus pallidus inferior ganglion of vagus nerve internal globus pallidus external globus pallidus tibia subthalamic nucleus synovial joint epithelium of colon Top expressed in left lung lobe membranous bone habenula Dermatocranium maxilla mandible lumbar subsegment of spinal cord molar iris rib More reference expression data BioGPS More reference expression data Gene ontology Molecular function zinc ion binding metal ion binding protein binding catalytic activity hedgehog family protein binding Cellular component cytoplasm membrane plasma membrane integral component of plasma membrane extracellular region cell surface ciliary membrane nucleus Biological process negative regulation of smoothened signaling pathway regulation of fibroblast growth factor receptor signaling pathway skeletal system morphogenesis animal organ morphogenesis neuroblast proliferation smoothened signaling pathway negative regulation of signal transduction dorsal/ventral pattern formation epithelial tube branching involved in lung morphogenesis signal transduction negative regulation of apoptotic process Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 64399 15245 Ensembl ENSG00000164161 ENSMUSG00000064325 UniProt Q96QV1 Q7TN16 RefSeq (mRNA) NM_022475 NM_020259 RefSeq (protein) NP_071920 NP_064655 Location (UCSC) Chr 4: 144.65 – 144.75 Mb Chr 8: 80.69 – 80.78 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Hedgehog interacting protein** (**HHIP**) is a [protein](/source/Protein) that in humans is encoded by the *HHIP* [gene](/source/Gene).[5][6][7]

This gene encodes a [protein](/source/Protein) similar to the mouse hedgehog interacting protein, a regulatory component of the [Hedgehog signaling pathway](/source/Hedgehog_signaling_pathway). Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic [development](/source/Developmental_biology), including [anteroposterior](/source/Anteroposterior#Anterior_and_posterior) patterns of limbs and regulation of left-right asymmetry.[7]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000164161](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000164161) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000064325](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000064325) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=64399). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=15245). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11435703_5-0)** Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". *Cytogenet Cell Genet*. **92** (3–4): 300–3. [doi](/source/Doi_(identifier)):[10.1159/000056918](https://doi.org/10.1159%2F000056918). [PMID](/source/PMID_(identifier)) [11435703](https://pubmed.ncbi.nlm.nih.gov/11435703). [S2CID](/source/S2CID_(identifier)) [32938414](https://api.semanticscholar.org/CorpusID:32938414).

1. **[^](#cite_ref-pmid11731473_6-0)** Ingham PW, McMahon AP (Dec 2001). ["Hedgehog signaling in animal development: paradigms and principles"](https://doi.org/10.1101%2Fgad.938601). *Genes Dev*. **15** (23): 3059–87. [doi](/source/Doi_(identifier)):[10.1101/gad.938601](https://doi.org/10.1101%2Fgad.938601). [PMID](/source/PMID_(identifier)) [11731473](https://pubmed.ncbi.nlm.nih.gov/11731473).

1. ^ [***a***](#cite_ref-entrez_7-0) [***b***](#cite_ref-entrez_7-1) ["Entrez Gene: HHIP hedgehog interacting protein"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=64399).

## Further reading

- Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". *Nature*. **397** (6720): 617–21. [Bibcode](/source/Bibcode_(identifier)):[1999Natur.397..617C](https://ui.adsabs.harvard.edu/abs/1999Natur.397..617C). [doi](/source/Doi_(identifier)):[10.1038/17611](https://doi.org/10.1038%2F17611). [PMID](/source/PMID_(identifier)) [10050855](https://pubmed.ncbi.nlm.nih.gov/10050855). [S2CID](/source/S2CID_(identifier)) [204991314](https://api.semanticscholar.org/CorpusID:204991314).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Clark HF, Gurney AL, Abaya E, et al. (2003). ["The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). *Genome Res*. **13** (10): 2265–70. [doi](/source/Doi_(identifier)):[10.1101/gr.1293003](https://doi.org/10.1101%2Fgr.1293003). [PMC](/source/PMC_(identifier)) [403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID](/source/PMID_(identifier)) [12975309](https://pubmed.ncbi.nlm.nih.gov/12975309).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Olsen CL, Hsu PP, Glienke J, et al. (2004). ["Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512291). *BMC Cancer*. **4**: 43. [doi](/source/Doi_(identifier)):[10.1186/1471-2407-4-43](https://doi.org/10.1186%2F1471-2407-4-43). [PMC](/source/PMC_(identifier)) [512291](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512291). [PMID](/source/PMID_(identifier)) [15294024](https://pubmed.ncbi.nlm.nih.gov/15294024).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Kayed H, Kleeff J, Esposito I, et al. (2005). "Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas". *Mol. Carcinog*. **42** (4): 183–92. [doi](/source/Doi_(identifier)):[10.1002/mc.20088](https://doi.org/10.1002%2Fmc.20088). [PMID](/source/PMID_(identifier)) [15754313](https://pubmed.ncbi.nlm.nih.gov/15754313). [S2CID](/source/S2CID_(identifier)) [85407133](https://api.semanticscholar.org/CorpusID:85407133).

- Martin ST, Sato N, Dhara S, et al. (2006). ["Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms"](https://doi.org/10.4161%2Fcbt.4.7.1802). *Cancer Biol. Ther*. **4** (7): 728–33. [doi](/source/Doi_(identifier)):[10.4161/cbt.4.7.1802](https://doi.org/10.4161%2Fcbt.4.7.1802). [PMID](/source/PMID_(identifier)) [15970691](https://pubmed.ncbi.nlm.nih.gov/15970691).

v t e Signaling pathway: hedgehog signaling pathway Ligands Sonic hedgehog Indian hedgehog Desert hedgehog Receptor Patched Smoothened Transcription factor GLI1 GLI2 GLI3 Other HHIP HHAT

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