# HEPN1

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Protein-coding gene in the species Homo sapiens

HEPN1 Identifiers Aliases HEPN1, hepatocellular carcinoma, down-regulated 1 External IDs OMIM: 611641; HomoloGene: 134601; GeneCards: HEPN1; OMA:HEPN1 - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,919,244 bp[1] End 124,920,677 bp[1] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle amygdala putamen C1 segment substantia nigra caudate nucleus hippocampus proper nucleus accumbens right frontal lobe hypothalamus n/a More reference expression data BioGPS n/a Orthologs Species Human Mouse Entrez 641654 n/a Ensembl ENSG00000221932 n/a UniProt Q6WQI6 n/a RefSeq (mRNA) NM_001037558 n/a RefSeq (protein) NP_001032647 n/a Location (UCSC) Chr 11: 124.92 – 124.92 Mb n/a PubMed search [2] n/a Wikidata View/Edit Human

**Hepatocellular carcinoma, down-regulated 1** is a [protein](/source/Protein) that in humans is encoded by the HEPN1 [gene](/source/Gene). [3]

## Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.[4] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.[5]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000221932](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000221932) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-2)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=641654). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-entrez_3-0)** ["Entrez Gene: Hepatocellular carcinoma, down-regulated 1"](https://www.ncbi.nlm.nih.gov/gene/641654). Retrieved 2017-09-12.

1. **[^](#cite_ref-4)** Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". *J Hepatol*. **39** (4): 580–6. [doi](/source/Doi_(identifier)):[10.1016/s0168-8278(03)00359-3](https://doi.org/10.1016%2Fs0168-8278%2803%2900359-3). [PMID](/source/PMID_(identifier)) [12971969](https://pubmed.ncbi.nlm.nih.gov/12971969).

1. **[^](#cite_ref-5)** Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". *J Hepatol*. **42** (6): 833–41. [doi](/source/Doi_(identifier)):[10.1016/j.jhep.2005.01.025](https://doi.org/10.1016%2Fj.jhep.2005.01.025). [PMID](/source/PMID_(identifier)) [15885354](https://pubmed.ncbi.nlm.nih.gov/15885354).

## Further reading

- Kim HS, Jung G (2014). ["Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor"](https://doi.org/10.1016%2Fj.febslet.2014.10.011). *FEBS Lett*. **588** (23): 4413–21. [Bibcode](/source/Bibcode_(identifier)):[2014FEBSL.588.4413K](https://ui.adsabs.harvard.edu/abs/2014FEBSL.588.4413K). [doi](/source/Doi_(identifier)):[10.1016/j.febslet.2014.10.011](https://doi.org/10.1016%2Fj.febslet.2014.10.011). [PMID](/source/PMID_(identifier)) [25448679](https://pubmed.ncbi.nlm.nih.gov/25448679). [S2CID](/source/S2CID_(identifier)) [859229](https://api.semanticscholar.org/CorpusID:859229).

*This article incorporates text from the [United States National Library of Medicine](/source/United_States_National_Library_of_Medicine), which is in the [public domain](/source/Public_domain).*

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