# Genostar

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**Genostar** is a [bioinformatics](/source/Bioinformatics) provider based in [Grenoble](/source/Grenoble), [France](/source/France). The company was founded in 2004 following the "Genostar consortium"[1] that was created in 1999 as a public-private consortium by Genome Express, Hybrigenics, [INRIA](/source/INRIA) (Institut National de Recherche en Informatique et Automatique / French National Institute for Research in Computer Science and Control)[2] and [The Pasteur Institute](/source/Pasteur_Institute).

## Software

Metabolic Pathway Builder is a bioinformatics environment dedicated to microbial research.[citation needed] This covers [sequence assembly](/source/Sequence_assembly), mapping, annotation transfer and identification of [protein domains](/source/Protein_domains), [comparative genomics](/source/Comparative_genomics), structural searches, [metabolic pathway](/source/Metabolic_pathway) analysis, modeling and simulation of biological networks. Genostar's software is [platform independent](/source/Platform_independent) and can thus be used for both [Mac OS X](/source/Mac_OS_X), [Windows](/source/Microsoft_Windows), and [Linux](/source/Linux).

### Sequence assembly

- Mapping an ensemble of sequences on a reference sequence
- between a reference sequence and contigs, between two sequences or between two sets of sequences
- finding of exact matches with minimum length using [MUMmer](/source/MUMmer)
- detection of specific regions and [SNPs](/source/SNPs)
- creation of an assembled sequence relative to reference sequences

### Genomic annotation

- Gene prediction: ab-initio gene prediction using a [Hidden Markov model](/source/Hidden_Markov_model) based method
- [BlastX](/source/BLAST_(biotechnology))
- Automatic annotation transfer using [BlastP](/source/BLAST_(biotechnology))

### Proteic annotation

Metabolic Pathway Builder integrates several methods dedicated to proteic annotation:

- [Pfam](/source/Pfam) domain prediction using [HMMER](/source/HMMER)
- Several [EMBOSS](/source/EMBOSS) methods (antigenic, 2D structure prediction)

### Expression Data Solution (EDS)

Genostar's Expression Data Solution (EDS) connects microarray data to genes, gene products and biochemical reactions, based on keywords and annotations. This software allows to:

- Assign expression values to the gene names and IDs
- Identify co-expressed genes and visually analyze the reactions and [metabolic pathways](/source/Metabolic_pathway) in which they are involved
- Identify and perform analysis on co-regulated genes in terms of genomic localization, functional annotation and metabolism
- Colorize CDSs of interest in genomic maps according to their expression values and highlight the corresponding reactions in interactive metabolic [KEGG](/source/KEGG) maps
- Analyze the significance of functional data of a collection or sub-collection of CDSs ([GO](/source/Gene_Ontology), KEGG and more): [Fisher test](/source/Fisher's_exact_test)
- Collect and visualize all functional data in exportable tables and maps

### Database

Genostar's MicroB database consists of genomic, proteic, biochemical and metabolic data from approximately 1100 bacterial and archaeal organis.

## Partners

- [INRIA](/source/INRIA) (Institut National de Recherche en Informatique et Automatique / French National Institute for Research in Computer Science and Control)
- [Swiss Institute of Bioinformatics](/source/Swiss_Institute_of_Bioinformatics)
- [ChemAxon](/source/ChemAxon)[3]

## Notes and references

1. ["GenoStar: A Bioinformatics Platform for Exploratory Genomics"](https://www.ercim.eu/publication/Ercim_News/enw51/rechenmann.html). *www.ercim.eu*. Retrieved 2024-07-23.

1. ["INRIA - Sociétés de technologie issues de l'INRIA"](https://web.archive.org/web/20100213055024/http://www.inria.fr/valorisation/societes/index.fr.html). Archived from [the original](http://www.inria.fr/valorisation/societes/index.fr.html) on 2010-02-13. Retrieved 2010-05-13.

1. ["Integrators « ChemAxon - toolkits and desktop applications for cheminformatics"](https://web.archive.org/web/20100511035000/http://www.chemaxon.com/about/our-partners/integrators/). Archived from [the original](http://www.chemaxon.com/about/our-partners/integrators/) on 2010-05-11. Retrieved 2010-05-16.

## External links

- [Genostar Expands Deal with Biopharma Merial To Help Hunt Pathogenic Virulence Factors](http://www.genomeweb.com/informatics/genostar-expands-deal-biopharma-merial-help-hunt-pathogenic-virulence-factors)
- [Genostar at Bio 2010](https://web.archive.org/web/20100413090511/http://bio2010.bdmetrics.com/CDT-6793300/Genostar/Details.aspx)

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Adapted from the Wikipedia article [Genostar](https://en.wikipedia.org/wiki/Genostar) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Genostar?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.