# GenScript Biotech
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{{short description|Biotechnology group}}
{{COI|date=May 2022}}
{{Infobox company
| name = GenScript Biotech Corporation
| logo = GenScript_Biotech_logo.svg
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| type = [Public](/source/Public_company)
| traded_as = {{hkex|1548}}
| industry = [Life sciences](/source/Life_sciences)
| founded = 2002
| founders = Fangliang Zhang, Ye Wang, Luquan Wang
| location =
| hq_location_city = [Nanjing](/source/Nanjing)
| hq_location_country =
| area_served = Worldwide
| key_people = Shao Weihui, [CEO](/source/Chief_executive_officer)
| products =
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| website = {{Official URL}}
}}
'''GenScript Biotech,''' fully known as '''GenScript Biotech Corporation''', usually referred to as simply '''GenScript''', is a Chinese biotech company.[{{cite web |author=Rick Mitchell |date=January 23, 2023 |title=Paul Hastings Advises GenScript, Probio on $224 Million Funding |url=https://news.bloomberglaw.com/business-and-practice/paul-hastings-advises-genscript-probio-on-224-million-funding |url-status=live |archive-url=https://archive.today/20230516095707/https://news.bloomberglaw.com/business-and-practice/paul-hastings-advises-genscript-probio-on-224-million-funding |archive-date=May 16, 2023 |work=[Bloomberg Law](/source/Bloomberg_Law)}}][{{cite web |author=Tim Gray |date=July 13, 2018 |title=The New Revolution Brought About by Gene Synthesis |url=https://www.nytimes.com/2018/07/13/business/trade-wars-global-funds.html |url-status=live |archive-url=https://archive.today/20230516071011/https://www.nytimes.com/2018/07/13/business/trade-wars-global-funds.html |archive-date=May 16, 2023 |work=[The New York Times](/source/The_New_York_Times)}}][Kate Knibbs. {{cite magazine | title=The Promise of Antibody Treatments for Covid-19 | magazine=[Wired](/source/Wired_(magazine)) | via= | date=May 22, 2020 | url=https://www.wired.com/story/coronavirus-covid-19-antibody-treatment/ | archive-url=https://archive.today/20230516132543/https://www.wired.com/story/coronavirus-covid-19-antibody-treatment/ | archive-date=May 16, 2023 | url-status=live }} ''[Wired.com](/source/Wired.com)''.][Weijing Zhou. {{cite web | title=KPCB invests $15 mln in Jinsite | publisher=[21st Century Business Herald](/source/21st_Century_Business_Herald) | date=June 20, 2009 | url=http://finance.sina.com.cn/roll/20090620/02196375537.shtml | archive-url=https://archive.today/20230517151939/http://finance.sina.com.cn/roll/20090620/02196375537.shtml | archive-date=May 17, 2023 | url-status=live }}][{{cite web |author=Venus Feng and Yoojung Lee |date=May 31, 2018 |title=Road to Chinese Pharma Riches Runs Through the Bronx, New Jersey |url=https://www.bloomberg.com/news/articles/2018-05-31/road-to-chinese-drug-riches-runs-through-the-bronx-new-jersey |url-status=live |archive-url=https://archive.today/20230516114001/https://www.bloomberg.com/news/articles/2018-05-31/road-to-chinese-drug-riches-runs-through-the-bronx-new-jersey |archive-date=May 16, 2023 |work=[Bloomberg News](/source/Bloomberg_News)}}] Headquartered in [Nanjing](/source/Nanjing),[{{Cite web |title=Genscript Biotech Corp Company Profile - Genscript Biotech Corp Overview |url=https://www.globaldata.com/company-profile/genscript-biotech-corp/ |archive-url=https://web.archive.org/web/20251206132535/https://www.globaldata.com/company-profile/genscript-biotech-corp/ |archive-date=2025-12-06 |access-date=2026-05-24 |website=www.globaldata.com |language=en-us |url-status=live }}] the company mainly provides [life science](/source/life_science) research application instruments and services.[{{cite web | author=Yuexiang Zhou | title=Singapore Strives to Become Asia's Biomedical Hub | work=[Lianhe Zaobao](/source/Lianhe_Zaobao) | date=May 10, 2023 | url=https://www.zaobao.com/finance/singapore/story20230510-1390556 | archive-url=https://archive.today/20230517093739/https://www.zaobao.com/finance/singapore/story20230510-1390556 | archive-date=May 17, 2023 | url-status=live }}] It was listed on the [Hong Kong Stock Exchange](/source/Hong_Kong_Stock_Exchange) in 2015.[{{cite web | author=Eric Ng | title=Genscript's shares jump by a third on US$350m Johnson & Johnson unit tie-up | work=[South China Morning Post](/source/South_China_Morning_Post) | date=December 22, 2017 | url=https://www.scmp.com/business/companies/article/2125467/chinese-biotech-firm-genscripts-shares-jump-third-us350m-johnson | archive-url=https://archive.today/20230516141207/https://www.scmp.com/business/companies/article/2125467/chinese-biotech-firm-genscripts-shares-jump-third-us350m-johnson | archive-date=May 16, 2023 | url-status=live }}] The current rotating CEO of the firm is Shao Weihui, who also served as the chief operating officer and [Chinese Communist Party Committee Secretary](/source/Chinese_Communist_Party_Committee_Secretary) for the company.[{{cite web | title=Genscript Biotech Corporation Announces Chief Executive Officer Changes | work=MarketScreener | date=December 18, 2022 | url=https://www.marketscreener.com/quote/stock/GENSCRIPT-BIOTECH-CORPORA-25502710/news/Genscript-Biotech-Corporation-Announces-Chief-Executive-Officer-Changes-42585866/ | archive-url=https://archive.today/20230620050228/https://www.marketscreener.com/quote/stock/GENSCRIPT-BIOTECH-CORPORA-25502710/news/Genscript-Biotech-Corporation-Announces-Chief-Executive-Officer-Changes-42585866/ | archive-date=June 20, 2023 | url-status=live }}][{{Cite web |date=2022-06-30 |title=我院党委与金斯瑞集团党委举行党建共建暨校企合作签约仪式 |trans-title=The Party Committee of our college and the Party Committee of GenScript Group held a signing ceremony for joint party building and school-enterprise cooperation |url=https://life.nju.edu.cn/life100/8e/ca/c42817a560842/page.htm |url-status=dead |archive-url=https://web.archive.org/web/20220630142659/https://life.nju.edu.cn/life100/8e/ca/c42817a560842/page.htm |archive-date=June 30, 2022 |access-date=2024-06-02 |website=[Nanjing University](/source/Nanjing_University) |language=zh}}] The company's main [subsidiaries](/source/subsidiaries) include Legend Biotech,[{{cite web | author=Russell Flannery (Forbes Staff) | title=Johnson & Johnson Partner's Stock Soars As Investors Embrace China Health, Tech | work=[Forbes](/source/Forbes) | date=June 7, 2020 | url=https://www.forbes.com/sites/russellflannery/2020/06/07/johnson-johnson-partners-stock-soars-as-investors-embrace-china-health-tech/ | archive-url=https://archive.today/20230618081547/https://www.forbes.com/sites/russellflannery/2020/06/07/johnson-johnson-partners-stock-soars-as-investors-embrace-china-health-tech/ | archive-date=June 18, 2023 | url-status=live }}] ProBio Technology,[{{cite web | author=Rick Mitchell | title=Wake Up Call: Kirkland, Cole Schotz Advising Bed Bath & Beyond | work=[Bloomberg Law](/source/Bloomberg_Law) | date=April 24, 2023 | url=https://news.bloomberglaw.com/business-and-practice/wake-up-call-kirkland-cole-schotz-advising-bed-bath-beyond | archive-url=https://archive.today/20230617032137/https://news.bloomberglaw.com/business-and-practice/wake-up-call-kirkland-cole-schotz-advising-bed-bath-beyond | archive-date=June 17, 2023 | url-status=live }}] and Bestzyme.[{{cite web | title=China Digest: Lynk Pharma, Bestzyme Bioengineering securing funding | work=[DealStreetAsia](/source/DealStreetAsia) | date=May 31, 2023 | url=https://www.dealstreetasia.com/stories/china-digest-lynk-bestzyme-345992 | archive-url=https://web.archive.org/web/20230618114221/https://www.dealstreetasia.com/stories/china-digest-lynk-bestzyme-345992 | archive-date=June 18, 2023 | url-status=live | author=Stephanie Li }}]
Outside of the United States, GenScript has established presences in China, Singapore, Japan, the United Kingdom, and the Netherlands, among others.[{{cite web | title=GenScript Launches A Protein Manufacturing Facility In Singapore | work=[Lianhe Zaobao](/source/Lianhe_Zaobao) | publisher=[Economic Development Board](/source/Economic_Development_Board) | date=January 10, 2023 | url=https://www.zaobao.com/wencui/social/story20230110-1352250 | archive-url=https://archive.today/20230617092423/https://www.zaobao.com/wencui/social/story20230110-1352250 | archive-date=June 17, 2023 | url-status=live }}] The company's operations are divided into four main segments, [CDMO](/source/contract_development_and_manufacturing_organization) platform, life-science services and products platform, integrated cell therapy platform, and industrial synthetic products platform.[{{cite web | title=GenScript and Probio Close Series A Financing with Investment from Hillhouse | website=[Paul Hastings](/source/Paul_Hastings) | date=September 6, 2021 | url=https://www.paulhastings.com/news/genscript-and-probio-close-series-a-financing-with-investment-from-hillhouse | archive-url=https://archive.today/20230610142436/https://www.paulhastings.com/news/genscript-and-probio-close-series-a-financing-with-investment-from-hillhouse | archive-date=June 10, 2023 | url-status=live }}]
== History ==
GenScript was formed in 2002 in New Jersey. In 2004, it set up a research and production base in Nanjing, China.[{{cite web | title=Handbook of GenScript Biotech (2022 Edition) | website=www.genscript.com | date=May 24, 2022 | url=https://www.genscript.com/gsfiles/techfiles/gene-synthesis-handbook-2019.pdf | archive-url=https://web.archive.org/web/20221206234444/https://www.genscript.com/gsfiles/techfiles/gene-synthesis-handbook-2019.pdf | archive-date=December 6, 2022 | url-status=live }}] In 2009, the company secured a $15 million investment from [KPCB China Fund](/source/Kleiner_Perkins).[{{cite web | author=Jonathan Shieber | title=Kleiner Perkins' Former Front Man In China Starts Fresh | work=[The Wall Street Journal](/source/The_Wall_Street_Journal) | date=July 17, 2009 | url=https://www.wsj.com/articles/BL-VCDB-2450 | archive-url=https://archive.today/20230617140818/https://www.wsj.com/articles/BL-VCDB-2450 | archive-date=June 17, 2023 | url-status=live }}]
In 2011, the company opened a subsidiary in Japan. In 2013, it established Bestzyme.[{{cite web | author=Preetika Rana | title=How China Is Evolving From a Maker of Copycat Medicines Into a Producer of Complex Drugs | work=[The Wall Street Journal](/source/The_Wall_Street_Journal) | date=August 5, 2018 | url=https://www.wsj.com/articles/j-j-bets-on-chinese-startup-that-uses-llama-dna-to-fight-cancer-1533470402 | archive-url=https://archive.today/20230516103959/https://www.wsj.com/articles/j-j-bets-on-chinese-startup-that-uses-llama-dna-to-fight-cancer-1533470402 | archive-date=May 16, 2023 | url-status=live }}] In 2015, GenScript [went public](/source/Initial_public_offering) on the [Hong Kong Stock Exchange](/source/Hong_Kong_Stock_Exchange).[{{cite journal |last1=Wei |first1=Jianshu |last2=Guo |first2=Yelei |last3=Wang |first3=Yao |last4=Wu |first4=Zhiqiang |last5=Bo |first5=Jian |last6=Zhang |first6=Bin |last7=Zhu |first7=Jun |last8=Han |first8=Weidong |title=Clinical development of CAR T cell therapy in China: 2020 update |journal=Cellular & Molecular Immunology |date=April 2021 |volume=18 |issue=4 |pages=792–804 |doi=10.1038/s41423-020-00555-x |pmid=32999455 |pmc=8115146 }}] with its [IND](/source/investigational_new_drug) application approved by the [CFDA](/source/China_Food_and_Drug_Administration).[{{cite journal |last1=Wei |first1=Jianshu |last2=Guo |first2=Yelei |last3=Wang |first3=Yao |last4=Wu |first4=Zhiqiang |last5=Bo |first5=Jian |last6=Zhang |first6=Bin |last7=Zhu |first7=Jun |last8=Han |first8=Weidong |title=Clinical development of CAR T cell therapy in China: 2020 update |journal=Cellular & Molecular Immunology |date=April 2021 |volume=18 |issue=4 |pages=792–804 |doi=10.1038/s41423-020-00555-x |pmid=32999455 |pmc=8115146 }}] In the same year, Legend Biotech USA Inc. and Legend Biotech Ireland Limited, non-wholly owned subsidiaries of GenScript,[{{cite news | title=GenScript Biotech Releases Announcement of its Latest Research and Development | work=MarketScreener | date=August 5, 2020 | url=https://www.marketscreener.com/quote/stock/GENSCRIPT-BIOTECH-CORPORA-25502710/news/Genscript-Biotech-VOLUNTARY-ANNOUNCEMENT-RESEARCH-AND-DEVELOPMENT-UPDATE-31065805/ | access-date=June 1, 2024 | archive-date=August 29, 2023 | archive-url=https://web.archive.org/web/20230829130641/https://www.marketscreener.com/quote/stock/GENSCRIPT-BIOTECH-CORPORA-25502710/news/Genscript-Biotech-VOLUNTARY-ANNOUNCEMENT-RESEARCH-AND-DEVELOPMENT-UPDATE-31065805/ | url-status=live }}] entered into a collaboration agreement with Janssen Biotech[{{cite news | title=Pharma Stock Roundup: Aerie's Rhopressa Approved, Label Expansion for BMY, Pfizer Drugs | work=[Yahoo! Finance](/source/Yahoo!_Finance) | date=December 22, 2017 | url=https://finance.yahoo.com/news/pharma-stock-roundup-aerie-apos-130201532.html | archive-url=https://archive.today/20230829130458/https://finance.yahoo.com/news/pharma-stock-roundup-aerie-apos-130201532.html | archive-date=August 29, 2023 | url-status=live | author=Arpita Dutt }}] to share CAR-T treatments in the US and China.[{{cite news | title=Chinese biotech: from copycat to innovator | newspaper=[Financial Times](/source/Financial_Times) | issn=0307-1766 | date=October 10, 2019 | url=https://www.ft.com/content/03812ddf-84a3-4540-9850-9a33cfe637d0 | archive-url=https://archive.today/20230829130431/https://www.ft.com/content/03812ddf-84a3-4540-9850-9a33cfe637d0 | archive-date=August 29, 2023 | url-status=live | author=Will Ballard }}] Subsequently, GenScript fully acquired CustomArray.[{{cite web | author=Vince Iral | title=Genscript Biotech to acquire US genomic sequencing company | work=[S&P Global](/source/S%26P_Global) | date=December 27, 2017 | url=https://www.spglobal.com/marketintelligence/en/news-insights/trending/kp_nk4xxb9xne06fo5dk3q2 | archive-url=https://web.archive.org/web/20230517175708/https://www.spglobal.com/marketintelligence/en/news-insights/trending/kp_nk4xxb9xne06fo5dk3q2 | archive-date=May 17, 2023 | url-status=live }}]
In 2020, its subsidiary Probio was launched.[{{cite web | author=Dede Williams | title=GenScript Raises $224 Million in Fresh Capital | work=CHEManager | date=January 25, 2023 | url=https://www.chemanager-online.com/en/news/genscript-raises-224-million-fresh-capital | archive-url=https://web.archive.org/web/20230610170937/https://www.chemanager-online.com/en/news/genscript-raises-224-million-fresh-capital | archive-date=June 10, 2023 | url-status=live }}] In the same year, Genscript collaborated with [Duke-NUS Medical School](/source/Duke-NUS_Medical_School) to develop and manufacture a serology test called cPass for the detection of COVID-19.[{{cite web | author=Lovelyn Tagalag | title=GenScript to collaborate with Singapore agency on COVID-19 test | work=[S&P Global](/source/S%26P_Global) | date=May 15, 2020 | url=https://www.spglobal.com/marketintelligence/en/news-insights/latest-news-headlines/genscript-to-collaborate-with-singapore-agency-on-covid-19-test-58645319 | archive-url=https://archive.today/20230516151004/https://www.spglobal.com/marketintelligence/en/news-insights/latest-news-headlines/genscript-to-collaborate-with-singapore-agency-on-covid-19-test-58645319 | archive-date=May 16, 2023 | url-status=live }}] On November 6, the cPass test received emergency use authorization from the [US FDA](/source/US_FDA).[{{cite web | title=Coronavirus (COVID-19) Update: FDA Authorizes First Test that Detects Neutralizing Antibodies from Recent or Prior SARS-CoV-2 Infection | publisher=[Food and Drug Administration](/source/Food_and_Drug_Administration) | website=www.fda.gov | date=November 6, 2020 | url=https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-test-detects-neutralizing-antibodies-recent-or | archive-url=https://web.archive.org/web/20201106201335/https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-test-detects-neutralizing-antibodies-recent-or | archive-date=November 6, 2020 | url-status=live }}][{{cite journal |last1=Tan |first1=Chee-Wah |last2=Chia |first2=Wan-Ni |last3=Young |first3=Barnaby E. |last4=Zhu |first4=Feng |last5=Lim |first5=Beng-Lee |last6=Sia |first6=Wan-Rong |last7=Thein |first7=Tun-Linn |last8=Chen |first8=Mark I.-C. |last9=Leo |first9=Yee-Sin |last10=Lye |first10=David C. |last11=Wang |first11=Lin-Fa |title=Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors |journal=[New England Journal of Medicine](/source/New_England_Journal_of_Medicine) |date=7 October 2021 |volume=385 |issue=15 |pages=1401–1406 |doi=10.1056/NEJMoa2108453 |pmid=34407341 |pmc=8422514 }}] Prior to that, Legend Biotech was listed on the [NASDAQ](/source/NASDAQ) under the symbol "LEGN".[{{cite web | author=Lucinda Shen | title=ZoomInfo raises nearly $1 billion in its IPO | work=[Fortune](/source/Fortune_(magazine)) | date=June 5, 2020 | url=https://fortune.com/2020/06/05/zoominfo-raises-nearly-1-billion-in-its-ipo/ | archive-url=https://archive.today/20230517072432/https://fortune.com/2020/06/05/zoominfo-raises-nearly-1-billion-in-its-ipo/ | archive-date=May 17, 2023 | url-status=live }}]
In 2022, Carvykti, a CAR-T cell therapy developed by Janssen Biotech and Legend Biotech,[{{cite web | author=Peter Loftus | title=FDA Approves Cell-Based Multiple Myeloma Therapy Discovered in China | work=[The Wall Street Journal](/source/The_Wall_Street_Journal) | date=February 28, 2022 | url=https://www.wsj.com/articles/fda-approves-cell-based-multiple-myeloma-therapy-discovered-in-china-11646091257 | archive-url=https://archive.today/20230516105735/https://www.wsj.com/articles/fda-approves-cell-based-multiple-myeloma-therapy-discovered-in-china-11646091257 | archive-date=May 16, 2023 | url-status=live }}] In the same year, it opened a protein and gene manufacturing facility in Singapore.[{{cite web | title=GenScript's manufacturing facility boosts S'pore's role in fight against pandemic | author=Timothy Goh | work=[The Straits Times](/source/The_Straits_Times) | date=February 10, 2022 | url=https://www.straitstimes.com/singapore/health/genscripts-manufacturing-facility-boosts-spores-role-in-fight-against-pandemic | archive-url=https://archive.today/20230618143824/https://www.straitstimes.com/singapore/health/genscripts-manufacturing-facility-boosts-spores-role-in-fight-against-pandemic | archive-date=June 18, 2023 | url-status=live }}]
In November 2023, Legend Biotech and [Novartis](/source/Novartis) signed an out-license deal to develop and manufacture Legend's [chimeric antigen receptor](/source/CAR_T_cell) (CAR-T) therapies, which target delta-like ligand protein 3 (DLL3), including large cell [neuroendocrine carcinoma](/source/Neuroendocrine_tumor) candidate LB2102. Novartis will pay the New-Jersey–based biotech $100 million upfront, and Legend Biotech will be eligible to receive up to $1.01 billion in clinical, regulatory, and commercial milestone payments and tiered royalties.[{{Cite web |last=Ojha |first=Shreeyashi |date=2023-11-15 |title=Legend & Novartis sign $100m agreement - BioProcess Insider |url=https://bioprocessintl.com/bioprocess-insider/deal-making/legend-and-novartis-sign-100m-car-t-license-agreement/ |access-date=2023-11-30 |website=BioProcess International |language=en-US }}{{Dead link|date=June 2024 |bot=InternetArchiveBot |fix-attempted=yes }}]
In May 2024, the [United States House Select Committee on Strategic Competition between the United States and the Chinese Communist Party](/source/United_States_House_Select_Committee_on_Strategic_Competition_between_the_United_States_and_the_Chinese_Communist_Party) asked the [Federal Bureau of Investigation](/source/Federal_Bureau_of_Investigation) (FBI) and [Director of National Intelligence](/source/Director_of_National_Intelligence) for a briefing on whether the Chinese government has any undue influence over GenScript and three of its subsidiaries (Bestzyme, Legend Biotech, and ProBio).[{{Cite news |last=Freifeld |first=Karen |date=May 31, 2024 |title=US lawmakers ask FBI for briefing on GenScript Biotech's links to China |url=https://www.reuters.com/business/healthcare-pharmaceuticals/us-lawmakers-ask-fbi-briefing-genscript-biotechs-links-china-2024-05-31/ |access-date=May 31, 2024 |work=[Reuters](/source/Reuters)}}][{{Cite web |date=2024-05-31 |title=Moolenaar, Krishnamoorthi Request FBI & DNI Briefing on Chinese Communist Party-Linked Biotech Firm |url=http://selectcommitteeontheccp.house.gov/media/press-releases/moolenaar-krishnamoorthi-request-fbi-dni-briefing-chinese-communist-party |access-date=2024-06-02 |website=[Select Committee on the CCP](/source/Select_Committee_on_the_CCP) |language=en |archive-date=2024-06-02 |archive-url=https://web.archive.org/web/20240602144245/https://selectcommitteeontheccp.house.gov/media/press-releases/moolenaar-krishnamoorthi-request-fbi-dni-briefing-chinese-communist-party |url-status=live }}] GenScript's stock fell as a result.[{{Cite news |last=Qin |first=Sherry |date=June 3, 2024 |title=GenScript Biotech Shares Drop After U.S. Lawmakers Scrutinize Chinese Ties |url=https://www.wsj.com/finance/stocks/genscript-biotech-shares-drop-after-u-s-lawmakers-scrutinize-chinese-ties-fadee581 |url-access=subscription |access-date=2024-06-04 |work=[The Wall Street Journal](/source/The_Wall_Street_Journal) |language=en-US |archive-date=2024-06-03 |archive-url=https://web.archive.org/web/20240603150830/https://www.wsj.com/finance/stocks/genscript-biotech-shares-drop-after-u-s-lawmakers-scrutinize-chinese-ties-fadee581 |url-status=live }}]
==References==
{{reflist}}
== External links ==
* {{Official website}}
Category:Companies listed on the Hong Kong Stock Exchange
Category:Biotechnology companies of the United States
Category:Companies established in 2002
Category:Companies based in Nanjing
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Adapted from the Wikipedia article [GenScript Biotech](https://en.wikipedia.org/wiki/GenScript_Biotech) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/GenScript_Biotech?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.