# GZMH
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> Source revision: 1300571623
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Granzyme H''' is a [protein](/source/protein) that in humans is encoded by the ''GZMH'' [gene](/source/gene).[{{cite journal |vauthors=Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M | title = Structure and evolutionary origin of the human granzyme H gene | journal = Int Immunol | volume = 3 | issue = 1 | pages = 57–66 |date=Jul 1991 | pmid = 2049336 | doi =10.1093/intimm/3.1.57 | url = http://doc.rero.ch/record/299888/files/3-1-57.pdf }}][{{cite web | title = Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2999}}]
==References==
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==Further reading==
{{refbegin | 2}}
*{{cite journal |vauthors=Waterhouse NJ, Trapani JA |title=H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. |journal=Trends Immunol. |volume=28 |issue= 9 |pages= 373–5 |year= 2007 |pmid= 17766182 |doi= 10.1016/j.it.2007.08.001 }}
*{{cite journal |vauthors=Llorens C, Martres MP, Baudry M, Schwartz JC |title=Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence. |journal=Nature |volume=274 |issue= 5671 |pages= 603–5 |year= 1978 |pmid= 209336 |doi=10.1038/274603a0 |bibcode=1978Natur.274..603L |s2cid=4293645 }}
*{{cite journal |vauthors=Heusel JW, Hanson RD, Silverman GA, Ley TJ |title=Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6152–8 |year= 1991 |doi=10.1016/S0021-9258(18)38097-9 |pmid= 2007574 |doi-access=free }}
*{{cite journal | author=Meier M |title=Cloning of a gene that encodes a new member of the human cytotoxic cell protease family |journal=Biochemistry |volume=29 |issue= 17 |pages= 4042–9 |year= 1990 |pmid= 2193684 |doi=10.1021/bi00469a003 |name-list-style=vanc| author2=Kwong PC | author3=Frégeau CJ | display-authors=3 | last4=Atkinson | first4=E. A. | last5=Burrington | first5=M. | last6=Ehrman | first6=N. | last7=Sorensen | first7=O. | last8=Lin | first8=C. C. | last9=Wilkins | first9=J. }}
*{{cite journal |vauthors=Hanson RD, Hohn PA, Popescu NC, Ley TJ |title=A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 3 |pages= 960–3 |year= 1990 |pmid= 2300587 |doi=10.1073/pnas.87.3.960 | pmc=53389 |bibcode=1990PNAS...87..960H |doi-access=free }}
*{{cite journal |vauthors=Klein JL, Selvakumar A, Trapani JA, Dupont B |title=Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C) |journal=Tissue Antigens |volume=35 |issue= 5 |pages= 220–8 |year= 1990 |pmid= 2402757 |doi=10.1111/j.1399-0039.1990.tb01787.x }}
*{{cite journal |vauthors=MacIvor DM, Pham CT, Ley TJ |title=The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice |journal=Blood |volume=93 |issue= 3 |pages= 963–73 |year= 1999 |doi=10.1182/blood.V93.3.963 |pmid= 9920846 |doi-access=free }}
*{{cite journal |vauthors=Edwards KM, Kam CM, Powers JC, Trapani JA |title=The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30468–73 |year= 1999 |pmid= 10521426 |doi=10.1074/jbc.274.43.30468 |doi-access=free }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal |vauthors=Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ |title=Cell death induced by granzyme C |journal=Blood |volume=101 |issue= 8 |pages= 3093–101 |year= 2003 |pmid= 12515723 |doi= 10.1182/blood-2002-08-2485 |doi-access= free }}
*{{cite journal | author=Sedelies KA |title=Discordant regulation of granzyme H and granzyme B expression in human lymphocytes |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26581–7 |year= 2004 |pmid= 15069086 |doi= 10.1074/jbc.M312481200 |name-list-style=vanc| author2=Sayers TJ | author3=Edwards KM | display-authors=3 | last4=Chen | first4=W | last5=Pellicci | first5=DG | last6=Godfrey | first6=DI | last7=Trapani | first7=JA | doi-access=free }}
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
*{{cite journal | author=Andrade F |title=Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition |journal=EMBO J. |volume=26 |issue= 8 |pages= 2148–57 |year= 2007 |pmid= 17363894 |doi= 10.1038/sj.emboj.7601650 | pmc=1852776 |name-list-style=vanc| author2=Fellows E | author3=Jenne DE | display-authors=3 | last4=Rosen | first4=Antony | last5=Young | first5=C S H }}
*{{cite journal |vauthors=Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC |title=Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program |journal=Blood |volume=110 |issue= 2 |pages= 544–52 |year= 2007 |pmid= 17409270 |doi= 10.1182/blood-2006-10-051649 |doi-access= free }}
{{refend}}
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Adapted from the Wikipedia article [GZMH](https://en.wikipedia.org/wiki/GZMH) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/GZMH?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.