# GOLGA5 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/GOLGA5 > Markdown URL: https://mediated.wiki/source/GOLGA5.md > Source: https://en.wikipedia.org/wiki/GOLGA5 > Source revision: 1301012139 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Golgin subfamily A member 5''' is a [protein](/source/protein) that in humans is encoded by the ''GOLGA5'' [gene](/source/gene).{{cite journal |vauthors=Ishizaka Y, Ochiai M, Tahira T, Sugimura T, Nagao M | title = Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing | journal = Oncogene | volume = 4 | issue = 6 | pages = 789–94 |date=Jul 1989 | pmid = 2734021 }}{{cite journal |vauthors=Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM | title = Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5 | journal = Cancer Res | volume = 58 | issue = 2 | pages = 198–203 |date=Feb 1998 | pmid = 9443391 }}{{cite journal |vauthors=Oka T, Ungar D, Hughson FM, Krieger M | title = The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins | journal = Mol Biol Cell | volume = 15 | issue = 5 | pages = 2423–35 |date=Apr 2004 | pmid = 15004235 | pmc = 404034 | doi = 10.1091/mbc.E03-09-0699 }}{{cite web | title = Entrez Gene: GOLGA5 golgi autoantigen, golgin subfamily a, 5| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9950}} The Golgi apparatus, which participates in [glycosylation](/source/glycosylation) and transport of proteins and lipids in the secretory pathway, consists of a series of stacked [cisternae](/source/Cisterna) (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a [coiled-coil](/source/Coiled_coil) membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. ==Interactions== GOLGA5 has been shown to [interact](/source/Protein-protein_interaction) with [RAB1A](/source/RAB1A).{{cite journal |doi=10.1034/j.1600-0854.2003.00103.x |last=Satoh |first=Ayano |author2=Wang Yanzhuang |author3=Malsam Jörg |author4=Beard Matthew B |author5=Warren Graham |date=Mar 2003 |title=Golgin-84 is a rab1 binding partner involved in Golgi structure |journal=Traffic |volume=4 |issue=3 |pages=153–61 |location = Denmark| issn = 1398-9219| pmid = 12656988 | pmc=3282115}}{{cite journal |last=Diao |first=Aipo |author2=Rahman Dinah |author3=Pappin Darryl J C |author4=Lucocq John |author5=Lowe Martin |date=Jan 2003 |title=The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation |journal=J. Cell Biol. |volume=160 |issue=2 |pages=201–12 |location = United States| issn = 0021-9525| pmid = 12538640 |doi = 10.1083/jcb.200207045 |pmc=2172652 }} ==References== {{Reflist}} ==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Short B, Barr FA |title=Membrane traffic: a glitch in the Golgi matrix. |journal=Curr. Biol. |volume=13 |issue= 8 |pages= R311–3 |year= 2004 |pmid= 12699642 |doi=10.1016/S0960982203002343 |doi-access=free }} *{{cite journal |vauthors=Bascom RA, Srinivasan S, Nussbaum RL |title=Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2953–62 |year= 1999 |pmid= 9915833 |doi=10.1074/jbc.274.5.2953 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Heilig R, Eckenberg R, Petit JL |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 |display-authors=etal|bibcode=2003Natur.421..601H |doi-access=free }} *{{cite journal |vauthors=Diao A, Rahman D, Pappin DJ |title=The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. |journal=J. Cell Biol. |volume=160 |issue= 2 |pages= 201–12 |year= 2003 |pmid= 12538640 |doi= 10.1083/jcb.200207045 | pmc=2172652 |display-authors=etal}} *{{cite journal |vauthors=Satoh A, Wang Y, Malsam J |title=Golgin-84 is a rab1 binding partner involved in Golgi structure. |journal=Traffic |volume=4 |issue= 3 |pages= 153–61 |year= 2003 |pmid= 12656988 |doi=10.1034/j.1600-0854.2003.00103.x |display-authors=etal |pmc=3282115}} *{{cite journal |vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal |vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 |display-authors=etal}} *{{cite journal |vauthors=Malsam J, Satoh A, Pelletier L, Warren G |title=Golgin tethers define subpopulations of COPI vesicles. |journal=Science |volume=307 |issue= 5712 |pages= 1095–8 |year= 2005 |pmid= 15718469 |doi= 10.1126/science.1108061 |bibcode=2005Sci...307.1095M |s2cid=12601850 }} *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }} {{refend}} {{gene-14-stub}} --- Adapted from the Wikipedia article [GOLGA5](https://en.wikipedia.org/wiki/GOLGA5) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/GOLGA5?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.