# GMPPB

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**Mannose-1-phosphate guanyltransferase beta** is an [enzyme](/source/Enzyme) that in humans is encoded by the *GMPPB* [gene](/source/Gene).[1]

This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to [GDP-mannose](/source/Guanosine_diphosphate_mannose) which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.[1]

## References

1. ["Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=29925)

## Further reading

- Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". *Nature*. **437** (7062): 1173–8. [Bibcode:2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi:10.1038/nature04209](https://doi.org/10.1038/nature04209). [PMID 16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID 4427026](https://api.semanticscholar.org/CorpusID:4427026)
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Clark HF, Gurney AL, Abaya E (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". *Genome Res.*. **13** (10): 2265–70. [doi:10.1101/gr.1293003](https://doi.org/10.1101/gr.1293003). [PMC 403697](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC403697). [PMID 12975309](https://pubmed.ncbi.nlm.nih.gov/12975309)
- Ono T, Sekino-Suzuki N, Kikkawa Y (2003). "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.". *J. Neurosci.*. **23** (13): 5887–96. [doi:10.1523/JNEUROSCI.23-13-05887.2003](https://doi.org/10.1523/JNEUROSCI.23-13-05887.2003). [PMC 6741272](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741272). [PMID 12843293](https://pubmed.ncbi.nlm.nih.gov/12843293)
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Nagase T, Nakayama M, Nakajima D (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". *DNA Res.*. **8** (2): 85–95. [doi:10.1093/dnares/8.2.85](https://doi.org/10.1093/dnares/8.2.85). [PMID 11347906](https://pubmed.ncbi.nlm.nih.gov/11347906)
- Ning B, Elbein AD (2001). "Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins.". *Eur. J. Biochem.*. **267** (23): 6866–74. [doi:10.1046/j.1432-1033.2000.01781.x](https://doi.org/10.1046/j.1432-1033.2000.01781.x). [PMID 11082198](https://pubmed.ncbi.nlm.nih.gov/11082198)

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Adapted from the Wikipedia article [GMPPB](https://en.wikipedia.org/wiki/GMPPB) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/GMPPB?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.