# Fructoside > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Fructoside > Markdown URL: https://mediated.wiki/source/Fructoside.md > Source: https://en.wikipedia.org/wiki/Fructoside > Source revision: 1352010223 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Fructoside" – news · newspapers · books · scholar · JSTOR (May 2025) (Learn how and when to remove this message) [Sucrose](/source/Sucrose), a common fructoside where glucose is bonded to fructose **Fructosides** are [glycosides](/source/Glycoside) that contain [fructose](/source/Fructose).[1] They are abundant in living organisms, food, and the environment. This makes them a particular interest in pharmacology and food science. C1 of fructose may be bonded to any organic moiety, forming a fructoside. The configuration of the fructoside can be denoted as an α-fructosidase or β-fructosidase depending on whether the organic moiety is bonded below or above the plane of fructose, respectively. The naming of fructoside-related enzymes also follows this nomenclature. ## Formation and cleavage The formation of fructosides is catalyzed through enzymes called fructosyltransferases.[2] These operate by transferring fructose to other organic moieties. This can be done repeatedly to make polymers or configure addition to diversify the molecule. Fructosyltransferases are most active in forming sucrose-derived fructosides and fructans.[2] The breakdown of fructosides is catalyzed through enzymes called fructosidases.[1] A notable example is the breakdown of [sucrose](/source/Sucrose) into glucose and fructose, which is catalyzed through a fructosidase called [invertase](/source/Invertase).[3] This is metabolically relevant since [glucose](/source/Glucose) and fructose are used as energy sources via [glycolysis](/source/Glycolysis). Some fructosides are resistant to breakdown, such as [fructans](/source/Fructan) - a [polymer](/source/Polymer) of fructose with glucose at the end which serves as a dietary fiber and promotes probiotic growth.[4] ## Research applications Phlorizin structure The formation of fructosides via fructosyltransferases can lead to drastic changes in the qualities of the target compound. [Phlorizin](/source/Phlorizin), a naturally occurring [glycoside](/source/Glycoside) that lowers blood sugar and thus has piqued medicinal interest,[5] is a target of interest. Phlorizin fructoside derivatives have a higher solubility than their phlorizin counterparts, increasing bioavailability. The role of fructosides in promoting microbiome health possibly can be used in tandem with phlorizin's blood-sugar reducing properties as well.[5] ## References 1. ^ [***a***](#cite_ref-Blanco_2017_1-0) [***b***](#cite_ref-Blanco_2017_1-1) Blanco A, Blanco G (2017), "Enzymes", *Medical Biochemistry*, Elsevier, pp. 153–175, [doi](/source/Doi_(identifier)):[10.1016/b978-0-12-803550-4.00008-2](https://doi.org/10.1016%2Fb978-0-12-803550-4.00008-2), [ISBN](/source/ISBN_(identifier)) [978-0-12-803550-4](https://en.wikipedia.org/wiki/Special:BookSources/978-0-12-803550-4){{[citation](https://en.wikipedia.org/wiki/Template:Citation)}}: CS1 maint: work parameter with ISBN ([link](https://en.wikipedia.org/wiki/Category:CS1_maint:_work_parameter_with_ISBN)) 1. ^ [***a***](#cite_ref-MarquezLopez_2023_2-0) [***b***](#cite_ref-MarquezLopez_2023_2-1) Márquez-López RE, Uc-Chuc MA, Loyola-Vargas VM, Santiago-García PA, López MG (2023-12-01). ["Fructosyltransferases in plants: Structure, function and application: A review"](https://linkinghub.elsevier.com/retrieve/pii/S2666893923000646). *Carbohydrate Polymer Technologies and Applications*. **6** 100343. [doi](/source/Doi_(identifier)):[10.1016/j.carpta.2023.100343](https://doi.org/10.1016%2Fj.carpta.2023.100343). [ISSN](/source/ISSN_(identifier)) [2666-8939](https://search.worldcat.org/issn/2666-8939). 1. **[^](#cite_ref-3)** Wind J, Smeekens S, Hanson J (October 2010). ["Sucrose: Metabolite and signaling molecule"](https://linkinghub.elsevier.com/retrieve/pii/S0031942210002906). *Phytochemistry*. **71** (14–15): 1610–1614. [Bibcode](/source/Bibcode_(identifier)):[2010PChem..71.1610W](https://ui.adsabs.harvard.edu/abs/2010PChem..71.1610W). [doi](/source/Doi_(identifier)):[10.1016/j.phytochem.2010.07.007](https://doi.org/10.1016%2Fj.phytochem.2010.07.007). [PMID](/source/PMID_(identifier)) [20696445](https://pubmed.ncbi.nlm.nih.gov/20696445). 1. **[^](#cite_ref-4)** Franco-Robles E, López MG (January 2015). Turrini A (ed.). ["Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417592). *TheScientificWorldJournal*. **2015** (1) 289267. [doi](/source/Doi_(identifier)):[10.1155/2015/289267](https://doi.org/10.1155%2F2015%2F289267). [ISSN](/source/ISSN_(identifier)) [2356-6140](https://search.worldcat.org/issn/2356-6140). [PMC](/source/PMC_(identifier)) [4417592](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417592). [PMID](/source/PMID_(identifier)) [25961072](https://pubmed.ncbi.nlm.nih.gov/25961072). 1. ^ [***a***](#cite_ref-HerreraGonzalez_2021_5-0) [***b***](#cite_ref-HerreraGonzalez_2021_5-1) Herrera-González A, Núñez-López G, Núñez-Dallos N, Amaya-Delgado L, Sandoval G, Remaud-Simeon M, et al. (June 2021). ["Enzymatic synthesis of phlorizin fructosides"](https://linkinghub.elsevier.com/retrieve/pii/S0141022921000417). *Enzyme and Microbial Technology*. **147** 109783. [doi](/source/Doi_(identifier)):[10.1016/j.enzmictec.2021.109783](https://doi.org/10.1016%2Fj.enzmictec.2021.109783). [PMID](/source/PMID_(identifier)) [33992405](https://pubmed.ncbi.nlm.nih.gov/33992405). v t e Glycosides (glycosidic bond) Glycone Fructoside Galactoside Glucoside Glucuronide Rhamnoside Riboside Aglycone Alcoholic glycoside Cardiac glycoside Bufadienolide Cardenolide Cyanogenic glycoside Glycosylamine Phenolic glycoside Anthraquinone glycoside Coumarin glycoside Flavonoid glycoside Saponin Steviol glycoside Thioglycoside Category Commons --- Adapted from the Wikipedia article [Fructoside](https://en.wikipedia.org/wiki/Fructoside) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Fructoside?action=history)). 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