# Fluticasone

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Fluticasone
> Markdown URL: https://mediated.wiki/source/Fluticasone.md
> Source: https://en.wikipedia.org/wiki/Fluticasone
> Source revision: 1338343745
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Use dmy dates|date=October 2022}}
{{cs1 config |name-list-style=vanc |display-authors=6}}
{{Infobox drug
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 458449795
| image = Fluticasone.svg
| image_class = skin-invert-image
| width = 200

<!--Clinical data-->| Drugs.com = 
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category = 
| routes_of_administration = [Intranasal](/source/Intranasal_administration), [inhalation](/source/inhalation), [topical](/source/Topical_administration)
| ATC_prefix = D07
| ATC_suffix = AC17
| ATC_supplemental = {{ATC|R01|AD08}} {{ATC|R03|BA05}} {{ATC|R01|AD58}}
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
| legal_CA = OTC <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->

<!--Pharmacokinetic data-->| bioavailability = 0.51% (Intranasal)
| protein_bound = 91.0%
| metabolism = Intranasal<br />[Liver](/source/Liver) ([CYP3A4](/source/CYP3A4)-mediated)
| elimination_half-life = 10 hours
| excretion = [Kidney](/source/Kidney)

<!--Identifiers-->| IUPHAR_ligand = 6699
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 90566-53-3
| PubChem = 5311101
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB00588
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4470631
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = CUT2W21N7U
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07981
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 5134
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201396
| synonyms = 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; ''S''-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate

<!--Chemical data-->| IUPAC_name = ''S''-fluoromethyl (6''S'',8''S'',9''R'',10''S'',11''S'',13''S'',14''S'',16''R'',17''R'')-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[''a'']phenanthrene-17-carbothioate
| C = 22
| H = 27
| F = 3
| O = 4
| S = 1
| SMILES = O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MGNNYOODZCAHBA-GQKYHHCASA-N
}}
<!-- Definition and symptoms -->

'''Fluticasone''' is a [manufactured](/source/synthetic_compound) [glucocorticoid](/source/glucocorticoid) used to treat [nasal congestion](/source/nasal_congestion).<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA574|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=574–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1337|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=1337–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA124|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=124–}}</ref><ref name="Drugs.com">{{Cite web|url=https://www.drugs.com/international/fluticasone.html|title = Fluticasone - FDA prescribing information, side effects and uses}}</ref><ref name="Briggs_et_al2012" /> Both the [ester](/source/ester)s, [fluticasone propionate](/source/fluticasone_propionate) (sold as Flovent) and [fluticasone furoate](/source/fluticasone_furoate), are also used as [topical](/source/topical_medication) [anti-inflammatories](/source/anti-inflammatory) and inhaled [corticosteroids](/source/corticosteroids), and are used much more commonly in comparison.<ref name="MortonHall2012" /><ref name="IndexNominum2000" /><ref name="Drugs.com" /><ref name="SprattoWoods2012" />

Fluticasone is on the [World Health Organization's List of Essential Medicines](/source/WHO_Model_List_of_Essential_Medicines).<ref name="WHO23rd">{{cite book | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | publisher = [World Health Organization](/source/World_Health_Organization) | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> In 2023, it was the 26th most commonly prescribed medication in the United States, with more than 21{{nbsp}}million prescriptions,<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Fluticasone Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Fluticasone | access-date = 17 August 2025 }}</ref> although it is also sold [over-the-counter](/source/over-the-counter_drugs) (OTC).<ref>{{cite web |url=https://www.drugs.com/pro/fluticasone-nasal-spray.html |title=Fluticasone Nasal Spray |access-date=21 October 2022}}</ref>

== See also ==
* [Fluticasone furoate](/source/Fluticasone_furoate)
** [Fluticasone furoate/vilanterol](/source/Fluticasone_furoate%2Fvilanterol)
* [Fluticasone propionate](/source/Fluticasone_propionate)
** [Fluticasone/salmeterol](/source/Fluticasone%2Fsalmeterol)

== References ==
{{Reflist|refs=
<ref name="Briggs_et_al2012">{{cite book | vauthors = Briggs GG, Freeman RK, Yaffe SJ | title = Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk | publisher = Lippincott Williams & Wilkins | page = 600 | year = 2012 | isbn = 978-1-4511-5359-0 | url = https://books.google.com/books?id=ScPvM03B3lUC&pg=PA600 }}</ref>
<ref name="SprattoWoods2012">{{cite book | vauthors = Spratto GR, Woods AL | title = Delmar Nurse's Drug Handbook 2012 | publisher = Cengage Learning | page = 748 | year = 2012 | isbn = 978-1-111-31065-3 | url = https://books.google.com/books?id=x-f-kedg9ukC&pg=PA748 }}</ref>
}}

{{Glucocorticoids and antiglucocorticoids}}
{{Nasal preparations}}
{{Asthma and copd_rx}}
{{Glucocorticoid receptor modulators}}
{{GlaxoSmithKline}}
{{Portal bar | Medicine}}
{{Authority control}}

Category:Anti-asthmatic agents
Category:Diketones
Category:Diols
Category:Drugs acting on the respiratory system
Category:Organofluorides
Category:Drugs developed by GSK plc
Category:Glucocorticoids
Category:Pregnanes
Category:Respiratory therapy
Category:Thioesters
Category:Over-the-counter drugs in the United States

{{respiratory-system-drug-stub}}

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Adapted from the Wikipedia article [Fluticasone](https://en.wikipedia.org/wiki/Fluticasone) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Fluticasone?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.