# FADS1 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/FADS1 > Markdown URL: https://mediated.wiki/source/FADS1.md > Source: https://en.wikipedia.org/wiki/FADS1 > Source revision: 1303336390 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Enzyme found in humans}} {{Infobox_gene}} '''Fatty acid desaturase 1''' ('''FADS1''') is an [enzyme](/source/enzyme) that in humans is encoded by the ''FADS1'' [gene](/source/gene). == Function == The protein encoded by the FADS1 gene is a member of the [fatty acid desaturase](/source/fatty_acid_desaturase) (FADS) gene family and desaturates omega-3 and omega-6 [polyunsaturated fatty acid](/source/polyunsaturated_fatty_acid)s at the delta-5 position, catalyzing the final step in the formation of [eicosapentaenoic acid](/source/eicosapentaenoic_acid) (EPA) and [arachidonic acid](/source/arachidonic_acid).{{cite journal|last1=Brenna|first1=J Thomas|title=An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Δ8-desaturates 20:2n-6 and 20:3n-3|journal=Journal of Lipid Research|date=June 2009|volume=50|issue=6|pages=1195–202|doi=10.1194/jlr.M800630-JLR200 |doi-access=free |pmid=19202133|pmc=2681401}} Desaturase enzymes (such as those encoded by FADS1) regulate unsaturation of [fatty acid](/source/fatty_acid)s through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an [N-terminal](/source/N-terminus) [cytochrome b5](/source/cytochrome_b5)-like domain and a [C-terminal](/source/C-terminus) multiple membrane-spanning desaturase portion, both of which are characterized by conserved [histidine](/source/histidine) motifs. This gene is clustered with family members FADS1 and [FADS2](/source/FADS2) at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.{{cite web | title = Entrez Gene: FADS1 fatty acid desaturase 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3992| access-date = }} == Clinical significance == [Single nucleotide polymorphisms](/source/Single_nucleotide_polymorphisms) (SNPs) of FADS1 and FADS2 may affect long-chain [polyunsaturated](/source/polyunsaturated) [fatty acids](/source/fatty_acids) (LC-PUFA) metabolism and have a potential role in the development of [atopic](/source/atopy) diseases.{{Cite journal | last1 = Lattka | first1 = E. | last2 = Illig | first2 = T. | last3 = Heinrich | first3 = J. | last4 = Koletzko | first4 = B. | title = ''FADS'' Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases | doi = 10.1159/000235559 | journal = Journal of Nutrigenetics and Nutrigenomics | volume = 2 | issue = 3 | pages = 119–128 | year = 2009 | pmid = 19776639 | pmc = | s2cid = 17077710 | url = https://epub.ub.uni-muenchen.de/16661/ | doi-access = free }} ==References== {{reflist}} {{Clear}} ==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} *{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-style=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }} *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=Akira | last5=Sugano | first5=Sumio }} *{{cite journal | author=Stöhr H |title=A Gene Map of the Best's Vitelliform Macular Dystrophy Region in Chromosome 11q12–q13.1 |journal=Genome Res. |volume=8 |issue= 1 |pages= 48–56 |year= 1998 |pmid= 9445487 |doi= 10.1101/gr.8.1.48| pmc=310689 |name-list-style=vanc| author2=Marquardt A | author3=Rivera A | display-authors=3 | last4=Cooper | first4=PR | last5=Nowak | first5=NJ | last6=Shows | first6=TB | last7=Gerhard | first7=DS | last8=Weber | first8=BH }} *{{cite journal |vauthors=Cho HP, Nakamura M, Clarke SD |title=Cloning, expression, and fatty acid regulation of the human delta-5 desaturase |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 37335–9 |year= 2000 |pmid= 10601301 |doi=10.1074/jbc.274.52.37335 |doi-access=free }} *{{cite journal | author=Leonard AE |title=cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid |journal=Biochem. J. |volume=347 Pt 3 |issue= 3|pages= 719–24 |year= 2000 |pmid= 10769175 |doi=10.1042/0264-6021:3470719 | pmc=1221008 |name-list-style=vanc| author2=Kelder B | author3=Bobik EG | display-authors=3 | last4=Chuang | first4=Lu-Te | last5=Parker-Barnes | first5=Jennifer M. | last6=Thurmond | first6=Jennifer M. | last7=Kroeger | first7=Paul E. | last8=Kopchick | first8=John J. | last9=Huang | first9=Yung-Sheng }} *{{cite journal |vauthors=Marquardt A, Stöhr H, White K, Weber BH |title=cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family |journal=Genomics |volume=66 |issue= 2 |pages= 175–83 |year= 2000 |pmid= 10860662 |doi= 10.1006/geno.2000.6196 }} *{{cite journal | author=Brizio C |title=Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 1008–16 |year= 2006 |pmid= 16643857 |doi= 10.1016/j.bbrc.2006.04.003 |name-list-style=vanc| author2=Galluccio M | author3=Wait R | display-authors=3 | last4=Torchetti | first4=Enza Maria | last5=Bafunno | first5=Valeria | last6=Accardi | first6=Rosita | last7=Gianazza | first7=Elisabetta | last8=Indiveri | first8=Cesare | last9=Barile | first9=Maria |bibcode=2006BBRC..344.1008B }} *{{cite journal | author=Schaeffer L |title=Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1745–56 |year= 2006 |pmid= 16670158 |doi= 10.1093/hmg/ddl117 |name-list-style=vanc| author2=Gohlke H | author3=Müller M | display-authors=3 | last4=Heid | first4=IM | last5=Palmer | first5=LJ | last6=Kompauer | first6=I | last7=Demmelmair | first7=H | last8=Illig | first8=T | last9=Koletzko | first9=B | doi-access=free }} *{{cite journal | author=Ma J |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 |name-list-style=vanc| author2=Dempsey AA | author3=Stamatiou D | display-authors=3 | last4=Marshall | first4=K.Wayne | last5=Liew | first5=Choong-Chin }} *{{cite journal | author=Dreesen TD |title=A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=75 |issue= 2 |pages= 97–106 |year= 2006 |pmid= 16846730 |doi= 10.1016/j.plefa.2006.05.001 |name-list-style=vanc| author2=Adamson AW | author3=Tekle M | display-authors=3 | last4=Tang | first4=Chongren | last5=Cho | first5=Hyekung P. | last6=Clarke | first6=Steven D. | last7=Gettys | first7=Thomas W. }} *{{cite journal | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |name-list-style=vanc| author2=Chu P | author3=Elisma F | display-authors=3 | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }} *{{cite journal | author=Risé P |title=Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells |journal=Eur. J. Pharmacol. |volume=571 |issue= 2–3 |pages= 97–105 |year= 2007 |pmid= 17655842 |doi= 10.1016/j.ejphar.2007.06.021 |name-list-style=vanc| author2=Ghezzi S | author3=Carissimi R | display-authors=3 | last4=Mastromauro | first4=Francesca | last5=Petroni | first5=Anna | last6=Galli | first6=Claudio }} {{refend}} {{Dioxygenases}} {{Enzymes}} {{Portal bar|Biology|border=no}} Category:EC 1.14.19 {{protein-stub}} --- Adapted from the Wikipedia article [FADS1](https://en.wikipedia.org/wiki/FADS1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/FADS1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.