# Emil Frei > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Emil_Frei > Markdown URL: https://mediated.wiki/source/Emil_Frei.md > Source: https://en.wikipedia.org/wiki/Emil_Frei > Source revision: 1345408518 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|American physician and oncologist}} {{Infobox scientist | name = Emil Frei III | image = Nci-vol-1838-300 Emil Frei.jpg | alt = | caption = | birth_name = | birth_date = {{birth date|1924|2|21|mf=yes}} | birth_place = [St. Louis, Missouri](/source/St._Louis%2C_Missouri) | death_date = {{death date and age|2013|4|30|1924|2|21}} | death_place = [Oak Park, Illinois](/source/Oak_Park%2C_Illinois) | citizenship = [United States](/source/United_States) | nationality = | other_names = | known_for = Cancer research | occupation = Physician | spouse = Elizabeth Smith (nurse), 1948-1986 (her death)
Adoria Brock, 1987-2009 (her death) | children = 5 | workplaces = [National Cancer Institute](/source/National_Cancer_Institute)
[MD Anderson Cancer Center](/source/MD_Anderson_Cancer_Center)
[Dana–Farber Cancer Institute](/source/Dana%E2%80%93Farber_Cancer_Institute) | alma_mater = [Colgate University](/source/Colgate_University)
[Yale School of Medicine](/source/Yale_School_of_Medicine) }} '''Emil "Tom" Frei III''' (February 21, 1924 – April 30, 2013) was an American physician and [oncologist](/source/oncology). He was the former director and former physician-in-chief of the [Dana–Farber Cancer Institute](/source/Dana%E2%80%93Farber_Cancer_Institute) in [Boston](/source/Boston), [Massachusetts](/source/Massachusetts). He was also the Richard and Susan Smith Distinguished Professor of Medicine at [Harvard Medical School](/source/Harvard_Medical_School).{{cite web|url=http://researchers.dana-farber.org/directory/profile.asp?dbase=main&setsize=16&picture_id=0000013&grouptype_typeid_data=2&gs=r&nxtfmt=r&display=Y&oldurl=Y&try2=Y&pict_id=0000013 |title=Official biography |work=Dana–Farber Cancer Institute |access-date=13 March 2013 |url-status=dead |archive-url=https://web.archive.org/web/20160304030938/http://researchers.dana-farber.org/directory/profile.asp?dbase=main&setsize=16&picture_id=0000013&grouptype_typeid_data=2&gs=r&nxtfmt=r&display=Y&oldurl=Y&try2=Y&pict_id=0000013 |archive-date=4 March 2016 }} == Early life and education == Frei was born in 1924 in St. Louis.{{cite news|last=Fox|first=Margalit|title=Emil Frei III, Who Put Cancer Cures in Reach, Dies at 89|url=https://www.nytimes.com/2013/05/05/science/emil-frei-iii-who-put-cancer-cures-in-reach-dies-at-89.html?hpw&_r=0|access-date=5 May 2013|newspaper=The New York Times|date=4 May 2013}} His mother nicknamed him Tom after [Tom Sawyer](/source/Tom_Sawyer).{{Cite journal |last=Holland |first=James F. |last2=Freireich |first2=Emil J. |date=2013-10-20 |title=Emil Frei III, 1924-2013 |url=https://ascopubs.org/doi/10.1200/JCO.2013.51.8126 |journal=Journal of Clinical Oncology |language=en |volume=31 |issue=30 |pages=3727–3730 |doi=10.1200/JCO.2013.51.8126 |issn=0732-183X|url-access=subscription }} His family owned the [stained glass](/source/stained_glass) manufacturer Emil Frei & Associates. He was inspired to study science after reading Hans Zinsser's book ''[Rats, Lice and History](/source/Rats%2C_Lice_and_History)''. Frei completed an accelerated pre-med [Colgate University](/source/Colgate_University) in 1944 after only 2 years of study{{cite web |url=http://cancerres.aacrjournals.org/content/73/15/4597 |title = Emil Frei III, MD: In Memoriam (1924–2013) {{!}} Cancer Research}} and his medical degree from [Yale University](/source/Yale_University) in 1948. == Career == He interned at [Firmin Desloge Hospital](/source/Firmin_Desloge_Hospital), now [St. Louis University Hospital](/source/St._Louis_University_Hospital) in St. Louis, Missouri and served as a physician in the [Korean War](/source/Korean_War). He worked at the [National Cancer Institute](/source/National_Cancer_Institute) from 1955 to 1965 and the [M. D. Anderson Cancer Center](/source/M._D._Anderson_Cancer_Center) from 1965 to 1972; while at M.D. Anderson he was the founding director of the Department of Development Therapeutics, which evolved into the Clinical Research Center. He served as physician-in-chief at the Dana-Farber Institute from 1972 to 1991. He is best known for his work on the treatment of lymphomas and childhood and adult leukemia.{{cite web|url=http://science.education.nih.gov/animalresearch.nsf/ResearcherName/Emil+Frei+III#Q1 |title=Emil Frei III |work=Animals in Research |publisher=National Institutes of Health |access-date=13 March 2013 |url-status=dead |archive-url=https://web.archive.org/web/20111030220536/http://science.education.nih.gov/AnimalResearch.nsf/ResearcherName/Emil+Frei+III |archive-date=30 October 2011 }} His groundbreaking research into then-controversial combination chemotherapy, including the [VAMP regimen](/source/VAMP_regimen), earned him many awards.{{Cite book|title=The Emperor of All Maladies|last=Mukherjee|first=Siddhartha|publisher=Scribbler|year=2011|location=NY|pages=139–142}} He coauthored ''[Holland–Frei Cancer Medicine](/source/Holland%E2%80%93Frei_Cancer_Medicine)'' with [James F. Holland](/source/James_F._Holland).{{Cite web |title=James F. Holland, physician who helped show chemotherapy could treat cancer, dies at 92 |url=https://www.washingtonpost.com/local/obituaries/james-f-holland-physician-who-helped-show-chemotherapy-could-treat-cancer-dies-at-92/2018/03/25/07817398-3038-11e8-8bdd-cdb33a5eef83_story.html |website=The Washington Post}} ===Involvement in Cancer Cooperative Group Research=== Frei was one of the founders of the Acute Leukemia Group B which later evolved into the [Cancer and Leukemia Group B](/source/Cancer_and_Leukemia_Group_B) (CALGB). He served as the group chair for 16 years, from 1956 to 1963, and again from 1981 to 1990.{{cite web|url=https://www.calgb.org/Public/about/history.php|title=History of CALGB|access-date=2013-05-01|archive-url=https://web.archive.org/web/20150907110944/https://www.calgb.org/Public/about/history.php|archive-date=2015-09-07|url-status=dead}} ===Journal of Clinical Oncology=== He coined the [Journal of Clinical Oncology](/source/Journal_of_Clinical_Oncology) in 1981, journal published first issue in 1983 in association with American Society of Clinical Oncology.{{cite journal |last1=Bertino |first1=Joseph R. |title=Editorial: A journal for Oncologists |journal=Journal of Clinical Oncology |date=1983 |volume=1|issue=1 |page=1 |doi=10.1200/JCO.1983.1.1.1 |url=http://jco.ascopubs.org/content/1/1/1.full.pdf+html|url-access=subscription }} ==Recognition== thumb|Dr. Emil Frei with Edna Jones in 1972 In 1972 he received the [Lasker-DeBakey Clinical Medical Research Award](/source/Lasker-DeBakey_Clinical_Medical_Research_Award) from the [Lasker Foundation](/source/Lasker_Foundation) "for his outstanding contribution in application of the concept of combination chemotherapy for lymphoma and acute adult leukemia."{{cite web|url=https://irp.nih.gov/about-us/honors/lasker-award|title=Lasker Award|work=National Institutes of Health|access-date=13 March 2013}} Other awards included the Jeffrey A. Gottlieb Memorial Award (1978); NIH Distinguished Alumni Award (1990); Fellow, [American Academy of Arts and Sciences](/source/American_Academy_of_Arts_and_Sciences) (1999); [Pollin Prize for Pediatric Research](/source/Pollin_Prize_for_Pediatric_Research) (2003); and [AARC Lifetime Achievement Award](/source/AACR_Awards) (2004).{{cite web|url=http://www.lib.utexas.edu/taro/utmda/00038/mda-00038.html|title=Biographical note: Emil Frei, III|work=Making Cancer History Voices Collection|publisher=University of Texas Archival Resources Online|access-date=13 March 2013}} * 2013 Fellow of the AACR Academy * 2004 [AACR Lifetime Achievement Award](/source/AACR_Lifetime_Achievement_Award) * 1999 Elected Fellow, [American Academy of Arts and Sciences](/source/American_Academy_of_Arts_and_Sciences) * 1997 Elected Member, [Institute of Medicine](/source/Institute_of_Medicine) * 1990 First NIH Distinguished Alumni Award * 1989 Armand Hammer Award * 1985 Hamao Umezawa Award, International Society of Chemotherapy, Infection and Cancer * 1983 [Charles F. Kettering Prize](/source/Charles_F._Kettering_Prize), General Motors Cancer Research Foundation * 1981 Golden Plate Award of the [American Academy of Achievement](/source/Academy_of_Achievement){{cite web|title= Golden Plate Awardees of the American Academy of Achievement |website=www.achievement.org|publisher=[American Academy of Achievement](/source/American_Academy_of_Achievement)|url=https://achievement.org/our-history/golden-plate-awards/#science-exploration}} * 1980 Elected fellow of the [American College of Physicians](/source/American_College_of_Physicians) * 1972 [Lasker-DeBakey Clinical Medical Research Award](/source/Lasker-DeBakey_Clinical_Medical_Research_Award) * 1971 President, [AACR](/source/American_Association_for_Cancer_Research) * 1968 President, [American Society of Clinical Oncology](/source/American_Society_of_Clinical_Oncology) ==Death== Frei died of [Parkinson's disease](/source/Parkinson's_disease) at his home in [Oak Park, Illinois](/source/Oak_Park%2C_Illinois) on April 30, 2013. He was 89. ==See also== * [History of cancer chemotherapy](/source/History_of_cancer_chemotherapy) ==References== {{reflist}} == External links == *[http://www.lib.utexas.edu/taro/utmda/00038/mda-00038.html Interview with Emil Frei] for the ''Making Cancer History Voices Collection'' at the [University of Texas](/source/University_of_Texas) {{Authority control}} {{DEFAULTSORT:Frei, Emil}} Category:1924 births Category:2013 deaths Category:American cancer researchers Category:Colgate University alumni Category:Harvard Medical School faculty Category:Medical doctors from St. Louis Category:Yale School of Medicine alumni Category:Recipients of the Lasker–DeBakey Clinical Medical Research Award Category:Members of the National Academy of Medicine Category:United States Navy personnel of the Korean War Category:20th-century American medical doctors --- Adapted from the Wikipedia article [Emil Frei](https://en.wikipedia.org/wiki/Emil_Frei) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Emil_Frei?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.