# Eddy Liew > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Eddy_Liew > Markdown URL: https://mediated.wiki/source/Eddy_Liew.md > Source: https://en.wikipedia.org/wiki/Eddy_Liew > Source revision: 1354131188 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Malaysian-born British immunologist}} {{Infobox scientist | name = Eddy Liew | native_name = 刘富友 | honorific_suffix = {{post-nominals|country=GBR|size=100%|OBE|FRS|FMedSci|FRSE|FRCPath}} | image = Eddy_Liew.jpg | image_size = 280 | alt = | caption = | birth_name = Eddy Foo Yew Liew | birth_place = [Kuala Lumpur, Malaysia](/source/Kuala_Lumpur%2C_Malaysia) | fields = [Immunology](/source/Immunology) | workplaces = [University of Glasgow](/source/University_of_Glasgow) | alma_mater = * [Monash University](/source/Monash_University) (BSc) * [Australian National University](/source/Australian_National_University) (PhD, DSc) | doctoral_advisor = | known_for = * CD4+ T cell heterogeneity * Nitric oxide in immune regulation * IL-15, IL-18 and IL-33 in inflammatory disease | academic_advisors = | awards = * [Fellow of the Royal Society of Edinburgh](/source/Fellow_of_the_Royal_Society_of_Edinburgh) (1995) * [Fellow of the Royal College of Pathologists](/source/Fellow_of_the_Royal_College_of_Pathologists) (1996) * [Fellow of the Academy of Medical Sciences](/source/Fellow_of_the_Academy_of_Medical_Sciences) (1999) * [Fellow of the Royal Society](/source/Fellow_of_the_Royal_Society) (2012) * [Officer of the Order of the British Empire](/source/Officer_of_the_Order_of_the_British_Empire) (2018) | website = }} '''Eddy Foo Yew Liew''' ({{lang-zh|s=刘富友}}) [OBE](/source/OBE) [FRS](/source/Fellow_of_the_Royal_Society) [FMedSci](/source/FMedSci) [FRSE](/source/FRSE) [FRCPath](/source/FRCPath) is a Malaysian-born British [immunologist](/source/immunologist) and Emeritus Professor of Immunology at the [University of Glasgow](/source/University_of_Glasgow). He is known for his contributions to the understanding of [CD4+ T cell](/source/CD4%2B_T_cell) heterogeneity, the role of [nitric oxide](/source/nitric_oxide) in immune regulation, and the discovery of key cytokine pathways involved in inflammatory disease. Liew is a Fellow of the [Royal Society](/source/Royal_Society) and the [Academy of Medical Sciences](/source/Academy_of_Medical_Sciences) and was appointed [Officer of the Order of the British Empire](/source/Officer_of_the_Order_of_the_British_Empire) in 2018 for services to science. == Early life and education == Liew attended Chong Hua High School on a scholarship before completing his secondary education at St. John’s Institution in Kuala Lumpur. In 1965 he received a Colombo Plan scholarship to study chemistry at [Monash University](/source/Monash_University) in Melbourne, graduating with a BSc (First Class Honours) in 1968. He completed his PhD in microbiology and immunology at the John Curtin School of Medical Research, [Australian National University](/source/Australian_National_University) (ANU), in 1972, and was later awarded a DSc by ANU in 1990.{{cite web |title=英国皇家学院院士F. Y. (EDDY) LIEW（刘富友）教授报告-IL-33 in infectious and inflammatory disease-安徽理工大学 |url=https://www.aust.edu.cn/info/1117/13268.htm |website=Aust.edu.cn}} == Career == Liew began his academic career in 1972 as a lecturer and later Associate Professor at the [University of Malaya](/source/University_of_Malaya) in Kuala Lumpur, Malaysia, where he served until 1977. In 1977, he moved to the United Kingdom to join the [Wellcome Research Laboratories](/source/Wellcome_Research_Laboratories) in Beckenham. He served as a Senior Scientist and subsequently as the Head of the Department of Immunobiology until 1991.{{cite journal |last1=Liew |first1=F. Y. |title=Immune suppressor substance in experimental chagas disease |journal=Parasitology Today |date=1 December 1988 |volume=4 |issue=12 |pages=355–356 |doi=10.1016/0169-4758(88)90006-3 |pmid=15463029 |url=https://www.cell.com/trends/parasitology/abstract/0169-4758(88)90006-3 |language=English |issn=0169-4758|url-access=subscription }} Liew joined the [University of Glasgow](/source/University_of_Glasgow) in 1991 as the Gardiner Professor and Head of the Department of Immunology, a position he held until 2008. During his tenure, he was the Founding Director of the Glasgow Biomedical Research Centre from 2002 to 2008. He has been an Emeritus Professor of Immunology at the university since 2008.{{cite web |title=Prof Foo Liew |url=https://www.gla.ac.uk/schools/infectionimmunity/staff/index.html/staffcontact/person/4cdeeee18290 |website=University of Glasgow |language=en}} From 2013 to 2019, Liew served as Editor-in-Chief of the ''[European Journal of Immunology](/source/European_Journal_of_Immunology)''.{{cite web |title=Leading immunologist elected Royal Society Fellow |url=https://www.gla.ac.uk/news/archiveofnews/2012/april/headline_231093_en.html |website=University of Glasgow |language=en}} ==Research== Liew’s research has focused on the regulation of immune responses, particularly the heterogeneity of CD4+ T lymphocytes and their roles in infectious and autoimmune diseases.{{cite journal |last1=Liew |first1=F. Y. |title=Functional heterogeneity of CD4+ T cells in leishmaniasis |journal=Immunology Today |date=February 1989 |volume=10 |issue=2 |pages=40–45 |doi=10.1016/0167-5699(89)90302-2 |pmid=2568842 |issn=0167-5699}} Early in his career, his work with Christopher Parish helped demonstrate that CD4+ T cells involved in cellular and humoral immunity belong to distinct functional subsets, showing that cell-mediated and antibody responses could be dissociated.{{cite journal |last1=Parish |first1=C. R. |last2=Liew |first2=F. Y. |title=Immune response to chemically modified flagellin. 3. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin |journal=The Journal of Experimental Medicine |date=1 February 1972 |volume=135 |issue=2 |pages=298–311 |doi=10.1084/jem.135.2.298 |pmid=5060292 |pmc=2180527 |issn=0022-1007}}{{cite journal |last1=Liew |first1=F. Y. |last2=Parish |first2=C. R. |title=Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect |journal=The Journal of Experimental Medicine |date=1 March 1974 |volume=139 |issue=3 |pages=779–784 |doi=10.1084/jem.139.3.779 |pmid=4544249 |pmc=2139557 |issn=0022-1007}} These findings contributed to the later definition of the Th1 and Th2 paradigm in immunology.{{cite journal |last1=Liew |first1=Foo Y. |title=T(H)1 and T(H)2 cells: a historical perspective |journal=Nature Reviews. Immunology |date=January 2002 |volume=2 |issue=1 |pages=55–60 |doi=10.1038/nri705 |pmid=11905838 |issn=1474-1733}} He subsequently extended this concept to several infectious diseases relevant to tropical regions, including tapeworm infection,{{cite journal |last1=Kwa |first1=B H |last2=Liew |first2=F Y |title=Immunity in taeniasis-cysticercosis I. Vaccination against Taenia taeniaeformis in rats using purified antigen. |journal=The Journal of Experimental Medicine |date=1 July 1977 |volume=146 |issue=1 |pages=118–131 |doi=10.1084/jem.146.1.118 |pmid=874421 |pmc=2180725 |url=https://rupress.org/jem/article/146/1/118/48589/Immunity-in-taeniasis-cysticercosis-I-Vaccination}} malaria,{{cite journal |last1=Taylor-Robinson |first1=Andrew W. |last2=Phillips |first2=R. Stephen |last3=Severn |first3=Alison |last4=Moncada |first4=Salvador |last5=Liew |first5=Foo Y. |title=The Role of TH1 and TH2 Cells in a Rodent Malaria Infection |journal=Science |date=25 June 1993 |volume=260 |issue=5116 |pages=1931–1934 |doi=10.1126/science.8100366 |pmid=8100366 |bibcode=1993Sci...260.1931T |url=https://www.science.org/doi/10.1126/science.8100366|url-access=subscription }} and leprosy.{{cite journal |last1=Smelt |first1=A. H. |last2=Rees |first2=R. J. |last3=Liew |first3=F. Y. |title=Induction of delayed-type hypersensitivity to Mycobacterium leprae in healthy individuals |journal=Clinical and Experimental Immunology |date=June 1981 |volume=44 |issue=3 |pages=501–506 |pmid=7035030 |pmc=1537322 |issn=0009-9104}} During his time at the Wellcome Research Laboratories, Liew investigated CD4+ T-cell responses in viral and parasitic infections. He reported that T cells primed by internal [influenza](/source/Influenza_A_virus) proteins could provide heterologous antibody responses and identified distinct CD4+ T-cell populations associated with resistance or susceptibility to ''[Leishmania](/source/Leishmania)'' infection.{{cite journal |last1=Liew |first1=F. Y. |last2=Millott |first2=S. |last3=Parkinson |first3=C. |last4=Palmer |first4=R. M. |last5=Moncada |first5=S. |title=Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine |journal=Journal of Immunology |date=15 June 1990 |volume=144 |issue=12 |pages=4794–4797 |doi=10.4049/jimmunol.144.12.4794 |pmid=2351828 |issn=0022-1767}} His group also described a population of CD4+ suppressor T cells capable of modulating disease-resistant responses, work that preceded later developments in [regulatory T-cell](/source/Regulatory_T_cell) biology. Liew made significant contributions to understanding the role of [nitric oxide](/source/nitric_oxide) (NO) in host defence. In collaboration with [Salvador Moncada](/source/Salvador_Moncada), he demonstrated that NO produced by macrophages is a key effector molecule in the killing of ''Leishmania'' parasites in vivo. Using inducible nitric oxide synthase (iNOS) knockout mice, he later showed that NO plays a pivotal role in protection against both ''Leishmania'' and malaria by promoting Th1-type immune responses.{{cite journal |last1=Niedbala |first1=W. |last2=Cai |first2=B. |last3=Liew |first3=F. Y. |title=Role of nitric oxide in the regulation of T cell functions |journal=Annals of the Rheumatic Diseases |date=November 2006 |volume=65 Suppl 3 |issue=Suppl 3 |pages=iii37–40 |doi=10.1136/ard.2006.058446 |pmid=17038470 |pmc=1798386 |issn=0003-4967}} At the [University of Glasgow](/source/University_of_Glasgow), Liew’s research expanded to include [cytokine](/source/cytokine) biology in inflammatory disease. Working with [Iain McInnes](/source/Iain_McInnes), he identified roles for [interleukin-15](/source/Interleukin_15) (IL-15) and [interleukin-18](/source/Interleukin_18) (IL-18) in [rheumatoid arthritis](/source/rheumatoid_arthritis).{{cite journal |last1=Gracie |first1=J. A. |last2=Forsey |first2=R. J. |last3=Chan |first3=W. L. |last4=Gilmour |first4=A. |last5=Leung |first5=B. P. |last6=Greer |first6=M. R. |last7=Kennedy |first7=K. |last8=Carter |first8=R. |last9=Wei |first9=X. Q. |last10=Xu |first10=D. |last11=Field |first11=M. |last12=Foulis |first12=A. |last13=Liew |first13=F. Y. |last14=McInnes |first14=I. B. |title=A proinflammatory role for IL-18 in rheumatoid arthritis |journal=The Journal of Clinical Investigation |date=November 1999 |volume=104 |issue=10 |pages=1393–1401 |doi=10.1172/JCI7317 |pmid=10562301 |pmc=409841 |issn=0021-9738}}{{cite journal |last1=McInnes |first1=Iain B. |last2=Liew |first2=Foo Y. |last3=Gracie |first3=J. Alastair |title=Interleukin-18: a therapeutic target in rheumatoid arthritis? |journal=Arthritis Res Ther |date=17 December 2004 |volume=7 |issue=1 |pages=38–41 |doi=10.1186/ar1497 |pmid=15642152 |pmc=1064903 |doi-access=free |language=en |issn=1478-6354}} His group also found that the receptor ST2 is preferentially expressed on Th2 cells, leading to the subsequent identification of [interleukin-33](/source/Interleukin_33) (IL-33) as its ligand.{{cite journal |last1=Liew |first1=Foo Yew |last2=Girard |first2=Jean-Philippe |last3=Turnquist |first3=Heth Roderick |title=Interleukin-33 in health and disease |journal=Nature Reviews. Immunology |date=November 2016 |volume=16 |issue=11 |pages=676–689 |doi=10.1038/nri.2016.95 |pmid=27640624 |issn=1474-1741}} Liew helped characterise the functions of IL-33 in immune regulation and inflammation, contributing to the broader understanding of this cytokine in human disease.{{cite journal |last1=McInnes |first1=Iain B. |last2=Liew |first2=Foo Y. |title=Cytokine networks—towards new therapies for rheumatoid arthritis |journal=Nature Clinical Practice Rheumatology |date=November 2005 |volume=1 |issue=1 |pages=31–39 |doi=10.1038/ncprheum0020 |pmid=16932625 |url=https://www.nature.com/articles/ncprheum0020 |language=en |issn=1745-8390|url-access=subscription }} == Honours and awards == * Almroth-Wright Lectures, [Imperial College London](/source/Imperial_College_London) (1991, 1998){{cite web |title=Almroth Wright Lecturers 1996 - present |url=https://www.imperial.ac.uk/media/imperial-college/research-centres-and-groups/institute-of-infection/Almroth-Wright-Lecturers-1996-to-present.pdf |publisher=Imperial College London}} * [Fellow of the Royal Society of Edinburgh](/source/Fellow_of_the_Royal_Society_of_Edinburgh) (FRSE) (1995){{cite web |title=Professor Eddy Liew |url=https://rse.org.uk/fellowship/fellow/professor-eddy-liew-1777/ |website=Royal Society of Edinburgh}} * [Fellow of the Royal College of Pathologists](/source/Fellow_of_the_Royal_College_of_Pathologists) (FRCPath) (1996) * [Fellow of the Academy of Medical Sciences](/source/Fellow_of_the_Academy_of_Medical_Sciences) (FMedSci) (1999){{cite web |title=Professor Eddy Liew |url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Eddy-Liew-0005802 |website=Academy of Medical Sciences}} * Hamdan Award for Medical Research Excellence, Hamdan Bin Rashid Al Maktoum Foundation (2002){{cite web |title=Sheikh Hamdan honours winners of Award for Medical Sciences |url=https://www.wam.ae/en/details/1395226945031 |publisher=Emirates News Agency}} * Honorary Member, German Society of Immunology (2007){{cite web |title=Prof. Eddy Liew Ehrenmitglied der Deutschen Gesellschaft für Immunologie |url=https://www.uni-heidelberg.de/presse/news07/2709liew.html |website=Heidelberg University}} * [Fellow of the Royal Society](/source/Fellow_of_the_Royal_Society) (FRS) (2012){{cite web |title=Professor Eddy Liew OBE FMedSci FRS |url=https://royalsociety.org/people/eddy-liew-11816/ |website=Royal Society |language=en}} * Member of the [Medical Research Club](/source/Medical_Research_Club) (2012) * Honorary Member, [British Society for Immunology](/source/British_Society_for_Immunology) (2012){{cite web |title=Honorary Members |url=https://www.immunology.org/about-us/our-people/our-members/honorary-members |website=British Society for Immunology}} * [Officer of the Order of the British Empire](/source/Officer_of_the_Order_of_the_British_Empire) (OBE), for services to science (2018){{cite web |title=Queen's Birthday Honours list 2018 |url=https://www.gov.scot/news/queens-birthday-honours-list-2018/ |website=The Scottish Government |language=en}} == References == {{reflist}} {{authority control}} {{DEFAULTSORT:Liew, Eddy}} Category:Living people Category:British immunologists Category:Malaysian emigrants to the United Kingdom Category:Monash University alumni Category:Australian National University alumni Category:Academics of the University of Glasgow Category:Fellows of the Royal Society of Edinburgh Category:Fellows of the Royal College of Pathologists Category:Fellows of the Academy of Medical Sciences (United Kingdom) Category:Officers of the Order of the British Empire Category:20th-century British scientists Category:21st-century British scientists Category:Year of birth missing (living people) Category:British fellows of the Royal Society --- Adapted from the Wikipedia article [Eddy Liew](https://en.wikipedia.org/wiki/Eddy_Liew) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Eddy_Liew?action=history)). 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