# ELOB

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/ELOB
> Markdown URL: https://mediated.wiki/source/ELOB.md
> Source: https://en.wikipedia.org/wiki/ELOB
> Source revision: 1313731418
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

Protein-coding gene in the species Homo sapiens

ELOB Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LM8, 1LQB, 1VCB, 2C9W, 2IZV, 2JZ3, 2MA9, 3DCG, 3ZKJ, 3ZNG, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4N9F, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L, 4WQO, 5BO4 Identifiers Aliases ELOB, SIII, TCEB2, transcription elongation factor B subunit 2, elongin B External IDs OMIM: 600787; HomoloGene: 134544; GeneCards: ELOB; OMA:ELOB - orthologs Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,771,414 bp[1] End 2,777,289 bp[1] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis apex of heart muscle of thigh stromal cell of endometrium anterior pituitary nucleus accumbens olfactory zone of nasal mucosa prefrontal cortex ganglionic eminence n/a More reference expression data BioGPS n/a Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component Cul2-RING ubiquitin ligase complex cytosol Cul5-RING ubiquitin ligase complex VCB complex nucleus elongin complex nucleoplasm Biological process transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription from RNA polymerase II promoter in response to hypoxia protein ubiquitination post-translational protein modification protein-containing complex assembly Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 6923 n/a Ensembl ENSG00000103363 n/a UniProt Q15370 n/a RefSeq (mRNA) NM_207013 NM_007108 n/a RefSeq (protein) NP_009039 NP_996896 n/a Location (UCSC) Chr 16: 2.77 – 2.78 Mb n/a PubMed search [2] n/a Wikidata View/Edit Human

**Elongin B** is a [protein](/source/Protein) that in humans is encoded by the *ELOB* [gene](/source/Gene).[3]

## Function

Elongin B is a subunit of the [transcription factor](/source/Transcription_factor) B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by [RNA polymerase II](/source/RNA_polymerase_II) by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The [von Hippel-Lindau tumor suppressor](/source/Von_Hippel-Lindau_tumor_suppressor) protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[4]

## Interactions

TCEB2 has been shown to [interact](/source/Protein-protein_interaction) with:

- [CUL2](/source/CUL2),[5][6]

- [TCEB1](/source/TCEB1),[7][8][9][10] and

- [Von Hippel-Lindau tumor suppressor](/source/Von_Hippel-Lindau_tumor_suppressor).[5][8][11][12][13]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000103363](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000103363) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-2)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6923). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid7638163_3-0)** Garrett KP, Aso T, Bradsher JN, Foundling SI, Lane WS, Conaway RC, Conaway JW (September 1995). ["Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41301). *Proc Natl Acad Sci U S A*. **92** (16): 7172–6. [Bibcode](/source/Bibcode_(identifier)):[1995PNAS...92.7172G](https://ui.adsabs.harvard.edu/abs/1995PNAS...92.7172G). [doi](/source/Doi_(identifier)):[10.1073/pnas.92.16.7172](https://doi.org/10.1073%2Fpnas.92.16.7172). [PMC](/source/PMC_(identifier)) [41301](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41301). [PMID](/source/PMID_(identifier)) [7638163](https://pubmed.ncbi.nlm.nih.gov/7638163).

1. **[^](#cite_ref-entrez_4-0)** ["ELOB elongin B \[ Homo sapiens (human) \]"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6923).

1. ^ [***a***](#cite_ref-pmid18173839_5-0) [***b***](#cite_ref-pmid18173839_5-1) Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). ["Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265268). *BMC Biochem*. **9**: 1. [doi](/source/Doi_(identifier)):[10.1186/1471-2091-9-1](https://doi.org/10.1186%2F1471-2091-9-1). [PMC](/source/PMC_(identifier)) [2265268](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265268). [PMID](/source/PMID_(identifier)) [18173839](https://pubmed.ncbi.nlm.nih.gov/18173839).

1. **[^](#cite_ref-pmid11384984_6-0)** Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (August 2001). ["Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase"](https://doi.org/10.1074%2Fjbc.M103093200). *J. Biol. Chem*. **276** (32): 29748–53. [doi](/source/Doi_(identifier)):[10.1074/jbc.M103093200](https://doi.org/10.1074%2Fjbc.M103093200). [PMID](/source/PMID_(identifier)) [11384984](https://pubmed.ncbi.nlm.nih.gov/11384984).

1. **[^](#cite_ref-pmid16189514_7-0)** Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

1. ^ [***a***](#cite_ref-pmid10587522_8-0) [***b***](#cite_ref-pmid10587522_8-1) Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999). ["Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481054). *J. Clin. Invest*. **104** (11): 1583–91. [doi](/source/Doi_(identifier)):[10.1172/JCI8161](https://doi.org/10.1172%2FJCI8161). [PMC](/source/PMC_(identifier)) [481054](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481054). [PMID](/source/PMID_(identifier)) [10587522](https://pubmed.ncbi.nlm.nih.gov/10587522).

1. **[^](#cite_ref-pmid7660129_9-0)** Krumm A, Groudine M (September 1995). "Tumor suppression and transcription elongation: the dire consequences of changing partners". *Science*. **269** (5229): 1400–1. [Bibcode](/source/Bibcode_(identifier)):[1995Sci...269.1400K](https://ui.adsabs.harvard.edu/abs/1995Sci...269.1400K). [doi](/source/Doi_(identifier)):[10.1126/science.7660121](https://doi.org/10.1126%2Fscience.7660121). [PMID](/source/PMID_(identifier)) [7660121](https://pubmed.ncbi.nlm.nih.gov/7660121). [S2CID](/source/S2CID_(identifier)) [39758696](https://api.semanticscholar.org/CorpusID:39758696).

1. **[^](#cite_ref-pmid11739384_10-0)** Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (February 2002). ["Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein"](https://doi.org/10.1074%2Fjbc.M108269200). *J. Biol. Chem*. **277** (7): 4656–62. [doi](/source/Doi_(identifier)):[10.1074/jbc.M108269200](https://doi.org/10.1074%2Fjbc.M108269200). [PMID](/source/PMID_(identifier)) [11739384](https://pubmed.ncbi.nlm.nih.gov/11739384).

1. **[^](#cite_ref-pmid17353931_11-0)** Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). ["Large-scale mapping of human protein-protein interactions by mass spectrometry"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). *Mol. Syst. Biol*. **3**: 89. [doi](/source/Doi_(identifier)):[10.1038/msb4100134](https://doi.org/10.1038%2Fmsb4100134). [PMC](/source/PMC_(identifier)) [1847948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). [PMID](/source/PMID_(identifier)) [17353931](https://pubmed.ncbi.nlm.nih.gov/17353931).

1. **[^](#cite_ref-pmid12004076_12-0)** Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (June 2002). ["Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling"](https://doi.org/10.1126%2Fscience.1073440). *Science*. **296** (5574): 1886–9. [Bibcode](/source/Bibcode_(identifier)):[2002Sci...296.1886M](https://ui.adsabs.harvard.edu/abs/2002Sci...296.1886M). [doi](/source/Doi_(identifier)):[10.1126/science.1073440](https://doi.org/10.1126%2Fscience.1073440). [PMID](/source/PMID_(identifier)) [12004076](https://pubmed.ncbi.nlm.nih.gov/12004076). [S2CID](/source/S2CID_(identifier)) [19641938](https://api.semanticscholar.org/CorpusID:19641938).

1. **[^](#cite_ref-pmid19030229_13-0)** Hacker KE, Lee CM, Rathmell WK (2008). Zhang B (ed.). ["VHL type 2B mutations retain VBC complex form and function"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583047). *PLOS ONE*. **3** (11) e3801. [Bibcode](/source/Bibcode_(identifier)):[2008PLoSO...3.3801H](https://ui.adsabs.harvard.edu/abs/2008PLoSO...3.3801H). [doi](/source/Doi_(identifier)):[10.1371/journal.pone.0003801](https://doi.org/10.1371%2Fjournal.pone.0003801). [PMC](/source/PMC_(identifier)) [2583047](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583047). [PMID](/source/PMID_(identifier)) [19030229](https://pubmed.ncbi.nlm.nih.gov/19030229).

## Further reading

- Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD (1995). ["Inhibition of transcription elongation by the VHL tumor suppressor protein"](https://zenodo.org/record/1231223). *Science*. **269** (5229): 1402–6. [Bibcode](/source/Bibcode_(identifier)):[1995Sci...269.1402D](https://ui.adsabs.harvard.edu/abs/1995Sci...269.1402D). [doi](/source/Doi_(identifier)):[10.1126/science.7660122](https://doi.org/10.1126%2Fscience.7660122). [PMID](/source/PMID_(identifier)) [7660122](https://pubmed.ncbi.nlm.nih.gov/7660122). [S2CID](/source/S2CID_(identifier)) [22334719](https://api.semanticscholar.org/CorpusID:22334719).

- Aso T, Lane WS, Conaway JW, Conaway RC (1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". *Science*. **269** (5229): 1439–43. [Bibcode](/source/Bibcode_(identifier)):[1995Sci...269.1439A](https://ui.adsabs.harvard.edu/abs/1995Sci...269.1439A). [doi](/source/Doi_(identifier)):[10.1126/science.7660129](https://doi.org/10.1126%2Fscience.7660129). [PMID](/source/PMID_(identifier)) [7660129](https://pubmed.ncbi.nlm.nih.gov/7660129). [S2CID](/source/S2CID_(identifier)) [37649908](https://api.semanticscholar.org/CorpusID:37649908).

- Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". *Science*. **269** (5229): 1444–6. [Bibcode](/source/Bibcode_(identifier)):[1995Sci...269.1444K](https://ui.adsabs.harvard.edu/abs/1995Sci...269.1444K). [doi](/source/Doi_(identifier)):[10.1126/science.7660130](https://doi.org/10.1126%2Fscience.7660130). [PMID](/source/PMID_(identifier)) [7660130](https://pubmed.ncbi.nlm.nih.gov/7660130). [S2CID](/source/S2CID_(identifier)) [25410108](https://api.semanticscholar.org/CorpusID:25410108).

- Bradsher JN, Jackson KW, Conaway RC, Conaway JW (1994). ["RNA polymerase II transcription factor SIII. I. Identification, purification, and properties"](https://doi.org/10.1016%2FS0021-9258%2819%2974431-7). *J. Biol. Chem*. **268** (34): 25587–93. [doi](/source/Doi_(identifier)):[10.1016/S0021-9258(19)74431-7](https://doi.org/10.1016%2FS0021-9258%2819%2974431-7). [PMID](/source/PMID_(identifier)) [8244996](https://pubmed.ncbi.nlm.nih.gov/8244996).

- Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997). ["The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20057). *Proc. Natl. Acad. Sci. U.S.A*. **94** (6): 2156–61. [Bibcode](/source/Bibcode_(identifier)):[1997PNAS...94.2156P](https://ui.adsabs.harvard.edu/abs/1997PNAS...94.2156P). [doi](/source/Doi_(identifier)):[10.1073/pnas.94.6.2156](https://doi.org/10.1073%2Fpnas.94.6.2156). [PMC](/source/PMC_(identifier)) [20057](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20057). [PMID](/source/PMID_(identifier)) [9122164](https://pubmed.ncbi.nlm.nih.gov/9122164).

- Li XY, Green MR (1998). ["The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317190). *Genes Dev*. **12** (19): 2992–6. [doi](/source/Doi_(identifier)):[10.1101/gad.12.19.2992](https://doi.org/10.1101%2Fgad.12.19.2992). [PMC](/source/PMC_(identifier)) [317190](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317190). [PMID](/source/PMID_(identifier)) [9765201](https://pubmed.ncbi.nlm.nih.gov/9765201).

- Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M (1999). ["The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26738). *Proc. Natl. Acad. Sci. U.S.A*. **96** (5): 2071–6. [Bibcode](/source/Bibcode_(identifier)):[1999PNAS...96.2071Z](https://ui.adsabs.harvard.edu/abs/1999PNAS...96.2071Z). [doi](/source/Doi_(identifier)):[10.1073/pnas.96.5.2071](https://doi.org/10.1073%2Fpnas.96.5.2071). [PMC](/source/PMC_(identifier)) [26738](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26738). [PMID](/source/PMID_(identifier)) [10051596](https://pubmed.ncbi.nlm.nih.gov/10051596).

- Stebbins CE, Kaelin WG, Pavletich NP (1999). "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function". *Science*. **284** (5413): 455–61. [Bibcode](/source/Bibcode_(identifier)):[1999Sci...284..455S](https://ui.adsabs.harvard.edu/abs/1999Sci...284..455S). [doi](/source/Doi_(identifier)):[10.1126/science.284.5413.455](https://doi.org/10.1126%2Fscience.284.5413.455). [PMID](/source/PMID_(identifier)) [10205047](https://pubmed.ncbi.nlm.nih.gov/10205047).

- Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD (1999). ["Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22243). *Proc. Natl. Acad. Sci. U.S.A*. **96** (17): 9533–8. [Bibcode](/source/Bibcode_(identifier)):[1999PNAS...96.9533P](https://ui.adsabs.harvard.edu/abs/1999PNAS...96.9533P). [doi](/source/Doi_(identifier)):[10.1073/pnas.96.17.9533](https://doi.org/10.1073%2Fpnas.96.17.9533). [PMC](/source/PMC_(identifier)) [22243](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22243). [PMID](/source/PMID_(identifier)) [10449727](https://pubmed.ncbi.nlm.nih.gov/10449727).

- Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A (1999). ["Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22941). *Proc. Natl. Acad. Sci. U.S.A*. **96** (22): 12436–41. [Bibcode](/source/Bibcode_(identifier)):[1999PNAS...9612436I](https://ui.adsabs.harvard.edu/abs/1999PNAS...9612436I). [doi](/source/Doi_(identifier)):[10.1073/pnas.96.22.12436](https://doi.org/10.1073%2Fpnas.96.22.12436). [PMC](/source/PMC_(identifier)) [22941](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22941). [PMID](/source/PMID_(identifier)) [10535940](https://pubmed.ncbi.nlm.nih.gov/10535940).

- Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (2000). ["Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481054). *J. Clin. Invest*. **104** (11): 1583–91. [doi](/source/Doi_(identifier)):[10.1172/JCI8161](https://doi.org/10.1172%2FJCI8161). [PMC](/source/PMC_(identifier)) [481054](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481054). [PMID](/source/PMID_(identifier)) [10587522](https://pubmed.ncbi.nlm.nih.gov/10587522).

- Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M (2000). ["Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis"](https://doi.org/10.1074%2Fjbc.275.9.6546). *J. Biol. Chem*. **275** (9): 6546–52. [doi](/source/Doi_(identifier)):[10.1074/jbc.275.9.6546](https://doi.org/10.1074%2Fjbc.275.9.6546). [PMID](/source/PMID_(identifier)) [10692460](https://pubmed.ncbi.nlm.nih.gov/10692460).

- Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). ["Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27041). *Proc. Natl. Acad. Sci. U.S.A*. **97** (19): 10430–5. [Bibcode](/source/Bibcode_(identifier)):[2000PNAS...9710430K](https://ui.adsabs.harvard.edu/abs/2000PNAS...9710430K). [doi](/source/Doi_(identifier)):[10.1073/pnas.190332597](https://doi.org/10.1073%2Fpnas.190332597). [PMC](/source/PMC_(identifier)) [27041](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27041). [PMID](/source/PMID_(identifier)) [10973499](https://pubmed.ncbi.nlm.nih.gov/10973499).

- Aso T, Yamazaki K, Aigaki T, Kitajima S (2000). "Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity". *Biochem. Biophys. Res. Commun*. **276** (1): 355–61. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2000.3451](https://doi.org/10.1006%2Fbbrc.2000.3451). [PMID](/source/PMID_(identifier)) [11006129](https://pubmed.ncbi.nlm.nih.gov/11006129).

- Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (2001). ["Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase"](https://doi.org/10.1074%2Fjbc.M103093200). *J. Biol. Chem*. **276** (32): 29748–53. [doi](/source/Doi_(identifier)):[10.1074/jbc.M103093200](https://doi.org/10.1074%2Fjbc.M103093200). [PMID](/source/PMID_(identifier)) [11384984](https://pubmed.ncbi.nlm.nih.gov/11384984).

- Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). ["Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein"](https://doi.org/10.1074%2Fjbc.M108269200). *J. Biol. Chem*. **277** (7): 4656–62. [doi](/source/Doi_(identifier)):[10.1074/jbc.M108269200](https://doi.org/10.1074%2Fjbc.M108269200). [PMID](/source/PMID_(identifier)) [11739384](https://pubmed.ncbi.nlm.nih.gov/11739384).

- Yamazaki K, Guo L, Sugahara K, Zhang C, Enzan H, Nakabeppu Y, Kitajima S, Aso T (2002). ["Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3"](https://doi.org/10.1074%2Fjbc.M202859200). *J. Biol. Chem*. **277** (29): 26444–51. [doi](/source/Doi_(identifier)):[10.1074/jbc.M202859200](https://doi.org/10.1074%2Fjbc.M202859200). [PMID](/source/PMID_(identifier)) [11994304](https://pubmed.ncbi.nlm.nih.gov/11994304).

- Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). ["Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling"](https://doi.org/10.1126%2Fscience.1073440). *Science*. **296** (5574): 1886–9. [Bibcode](/source/Bibcode_(identifier)):[2002Sci...296.1886M](https://ui.adsabs.harvard.edu/abs/2002Sci...296.1886M). [doi](/source/Doi_(identifier)):[10.1126/science.1073440](https://doi.org/10.1126%2Fscience.1073440). [PMID](/source/PMID_(identifier)) [12004076](https://pubmed.ncbi.nlm.nih.gov/12004076). [S2CID](/source/S2CID_(identifier)) [19641938](https://api.semanticscholar.org/CorpusID:19641938).

- Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY (2002). "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL". *Nature*. **417** (6892): 975–8. [Bibcode](/source/Bibcode_(identifier)):[2002Natur.417..975H](https://ui.adsabs.harvard.edu/abs/2002Natur.417..975H). [doi](/source/Doi_(identifier)):[10.1038/nature00767](https://doi.org/10.1038%2Fnature00767). [PMID](/source/PMID_(identifier)) [12050673](https://pubmed.ncbi.nlm.nih.gov/12050673). [S2CID](/source/S2CID_(identifier)) [4388644](https://api.semanticscholar.org/CorpusID:4388644).

## External links

- [PDBe-KB](https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q15370) provides an overview of all the structure information available in the PDB for Human Elongin-B

v t e PDB gallery 1lm8: Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex 1lqb: Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex 1vcb: THE VHL-ELONGINC-ELONGINB STRUCTURE 2c9w: CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION 2fnj: Crystal structure of a B30.2/SPRY domain-containing protein GUSTAVUS in complex with Elongin B and Elongin C 2izv: CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION

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