# DopAmide

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/DopAmide
> Markdown URL: https://mediated.wiki/source/DopAmide.md
> Source: https://en.wikipedia.org/wiki/DopAmide
> Source revision: 1328672157
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Dopaminergic agent}}
{{Infobox drug
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| image = DopAmide.png
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| class = [Monoamine precursor](/source/Monoamine_precursor); [Dopamine receptor agonist](/source/Dopamine_receptor_agonist)
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| CAS_number = 73148-96-6
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| PubChem = 424633
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| ChemSpiderID = 375743
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| synonyms = <small>L</small>-DopAmide; 3-Hydroxytyrosinamide

<!-- Chemical data -->
| IUPAC_name = 2-amino-3-(3,4-dihydroxyphenyl)propanamide
| C=9 | H=12 | N=2 | O=3
| SMILES = C1=CC(=C(C=C1CC(C(=O)N)N)O)O
| StdInChI = 1S/C9H12N2O3/c10-6(9(11)14)3-5-1-2-7(12)8(13)4-5/h1-2,4,6,12-13H,3,10H2,(H2,11,14)
| StdInChIKey = DXOJUCNAHCVBRU-UHFFFAOYSA-N
}}

'''DopAmide''', or '''<small>L</small>-DopAmide''', is a [synthetic](/source/synthetic_compound) [levodopa](/source/levodopa) (<small>L</small>-DOPA) [analogue](/source/structural_analog) that can serve as a levodopa and [dopamine](/source/dopamine_(medication)) [prodrug](/source/prodrug) and is of potential interest in the treatment of [Parkinson's disease](/source/Parkinson's_disease).<ref name="KangMiaoLiu2021">{{cite journal | vauthors = Kang T, Miao Z, Liu S, Ke B | title = Prodrug Strategies in the CNS Drugs: Small Modification Makes Big Improvements | journal = Current Topics in Medicinal Chemistry | volume = 21 | issue = 24 | pages = 2157–2169 | date = 2021 | pmid = 34315372 | doi = 10.2174/1568026621666210727163827 }}</ref><ref name="UrsoChaudhuriQamar2020">{{cite journal | vauthors = Urso D, Chaudhuri KR, Qamar MA, Jenner P | title = Improving the Delivery of Levodopa in Parkinson's Disease: A Review of Approved and Emerging Therapies | journal = CNS Drugs | volume = 34 | issue = 11 | pages = 1149–1163 | date = November 2020 | pmid = 33146817 | doi = 10.1007/s40263-020-00769-7 }}</ref><ref name="Atlas2016">{{cite journal | vauthors = Atlas D | title = DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons | journal = CNS Neuroscience & Therapeutics | volume = 22 | issue = 6 | pages = 461–467 | date = June 2016 | pmid = 26861609 | pmc = 6492885 | doi = 10.1111/cns.12518 }}</ref> DopAmide has an [amide](/source/amide) rather than the [carboxyl group](/source/carboxyl_group) of <small>L</small>-DOPA,<ref name="UrsoChaudhuriQamar2020" /><ref name="Atlas2016" /> which imparts greater [water solubility](/source/water_solubility).<ref name="KangMiaoLiu2021" /><ref name="UrsoChaudhuriQamar2020" /><ref name="Atlas2016" /> The amide is [hydrolyze](/source/hydrolyze)d back to the acid by [aminopeptidase](/source/aminopeptidase) [enzyme](/source/enzyme)s.<ref name="KangMiaoLiu2021" /><ref name="UrsoChaudhuriQamar2020" /><ref name="Atlas2016" /> 

== See also ==
* [DA-Phen](/source/DA-Phen)
* [Foslevodopa](/source/Foslevodopa)
* [Melevodopa](/source/Melevodopa)
* [Etilevodopa](/source/Etilevodopa)
* [''O'',''O''′-Diacetyldopamine](/source/O%2CO%E2%80%B2-Diacetyldopamine)
* [''O'',''O''′-Dipivaloyldopamine](/source/O%2CO%E2%80%B2-Dipivaloyldopamine)
* [Neurotransmitter prodrug](/source/Neurotransmitter_prodrug)

== References ==
{{Reflist}}

{{Dopamine receptor modulators}}
{{Phenethylamines}}

Category:Antiparkinsonian agents
Category:Catecholamines
Category:Dopamine agonists
Category:Experimental drugs
Category:Monoamine precursors
Category:Prodrugs
Category:Amides

{{Nervous-system-drug-stub}}

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Adapted from the Wikipedia article [DopAmide](https://en.wikipedia.org/wiki/DopAmide) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DopAmide?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.