# DiOC6

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**DiOC6** (3,3′-dihexyloxacarbocyanine iodide) is a [fluorescent dye](/source/Fluorescent_dye) used for the staining of a cell's [endoplasmic reticulum](/source/Endoplasmic_reticulum),[2] vesicle membranes and [mitochondria](/source/Mitochondria).[3] Binding to these structures occurs via the dye's [hydrophilic](/source/Hydrophilic) groups. DiOC6 can be used to label living cells, however they are quickly damaged due to the dye's extreme [phototoxicity](/source/Phototoxicity), so cells stained with this dye can only be exposed to light for short periods of time. When exposed to blue light, the dye [fluoresces](/source/Fluorescence) green.

## See also

- [DiI](/source/DiI)

## References

1. [3,3′-Dihexyloxacarbocyanine iodide](http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=318426|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC) at [Sigma-Aldrich](/source/Sigma-Aldrich)

1. Terasaki M. (1989). "Fluorescent labeling of endoplasmic reticulum". *Methods Cell Biol.*. **29**: 125–35. [doi:10.1016/s0091-679x(08)60191-0](https://doi.org/10.1016/s0091-679x(08)60191-0). [PMID 2643757](https://pubmed.ncbi.nlm.nih.gov/2643757)

1. Koning AJ et al. (1993). "DiOC6 staining reveals organelle structure and dynamics in living yeast cells". *[Cell Motil Cytoskeleton](/source/Cell_Motil_Cytoskeleton)*. **25** (2): 111–28. [doi:10.1002/cm.970250202](https://doi.org/10.1002/cm.970250202). [PMID 7686821](https://pubmed.ncbi.nlm.nih.gov/7686821)

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