# Destrin

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> Markdown URL: https://mediated.wiki/source/Destrin.md
> Source: https://en.wikipedia.org/wiki/Destrin
> Source revision: 1301007923
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein found in humans}}
{{infobox protein
| Name = Destrin (actin binding protein)
| caption = [Nuclear magnetic resonance](/source/Protein_nuclear_magnetic_resonance_spectroscopy) determined configuration of the tertiary structure of Destrin.<ref name="pmid8674111">{{PDB|1AK6}}; {{cite journal | vauthors = Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F | title = Tertiary structure of destrin and structural similarity between two actin-regulating protein families | journal = Cell | volume = 85 | issue = 7 | pages = 1047–55 |date=June 1996 | pmid = 8674111 | doi = 10.1016/S0092-8674(00)81305-7  | s2cid = 11470231 | doi-access = free }}</ref>
| image = Destrin.png
| width = 
| HGNCid = 15750
| Symbol = DSTN
| AltSymbols = ADF
| EntrezGene = 11034
| OMIM = 609114
| RefSeq = NM_006870
| UniProt = P60981
| PDB = 
| ECnumber = 
| Chromosome = 20
| Arm = p
| Band = 12.1
| LocusSupplementaryData = 
}}
'''Destrin''' or '''DSTN''' (also known as '''actin depolymerizing factor''' or '''ADF''') is a [protein](/source/protein) which in humans is encoded by the ''DSTN'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: Destrin | url =https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11034 }}</ref><ref name="pmid8399167">{{cite journal | vauthors = Hawkins M, Pope B, Maciver SK, Weeds AG | title = Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments | journal = Biochemistry | volume = 32 | issue = 38 | pages = 9985–93 |date=September 1993 | pmid = 8399167 | doi = 10.1021/bi00089a014}}</ref><ref name="pmid11780052">{{cite journal | vauthors = Deloukas P, Matthews LH, Ashurst J | title = The DNA sequence and comparative analysis of human chromosome 20 | journal = Nature | volume = 414 | issue = 6866 | pages = 865–71 | year = 2001 | pmid = 11780052 | doi = 10.1038/414865a | bibcode = 2001Natur.414..865D |display-authors=etal| doi-access = free }}</ref> Destrin is a component protein in [microfilament](/source/microfilament)s.

The product of this gene belongs to the [actin](/source/actin)-binding proteins ADF (Actin-Depolymerizing Factor)/[cofilin](/source/cofilin) family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez"/>

==Structure==
The tertiary structure of destrin was determined by the use of triple-resonance multidimensional nuclear magnetic resonance, or [NMR](/source/Protein_nuclear_magnetic_resonance_spectroscopy) for short.<ref name="pmid8674111"/>  The secondary and tertiary structures of destrin are similar to the [gelsolin](/source/gelsolin) family which is another actin-regulating protein family.

There are three ordered layers to destrin which is a globular protein.  There is a central [β sheet](/source/%CE%B2_sheet) that is composed of one parallel strand and three antiparallel strands.  This β sheet is between a long [α helix](/source/%CE%B1_helix) along with a shorter one and two shorter helices on the opposite side.  The four helices are parallel to the β strands.<ref name="pmid8674111"/>

==Function==
In a variety of [eukaryotes](/source/eukaryotes), destrin regulates actin in the cytoskeleton.  Destrin binds actin and is thought to connect it as gelsolin segment-1 does.  Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation.  Destrin can also sever actin filaments.<ref name="pmid8674111"/>

==References==

{{Reflist}}

==External links==
* {{MeshName|Destrin}}
*  [Ramachandran Plot](/source/Ramachandran_Plot) for destrin: {{cite web | url = http://www.rcsb.org/pdb/images/1AK6_ram_m_500.pdf | title = MolProbity Ramachandran analysis for 1ak6 | publisher = www.rcsb.org | archive-url = https://web.archive.org/web/20121012063107/http://www.rcsb.org/pdb/images/1AK6_ram_m_500.pdf | archive-date = 2012-10-12 | url-status = dead }}

{{Cytoskeletal Proteins}}

{{NLM content}}

Category:Protein families

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Adapted from the Wikipedia article [Destrin](https://en.wikipedia.org/wiki/Destrin) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Destrin?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.