# Denopamine

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Denopamine
> Markdown URL: https://mediated.wiki/source/Denopamine.md
> Source: https://en.wikipedia.org/wiki/Denopamine
> Source revision: 1336413221
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = 4-[(1''S'')-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
| image = Denopamine.svg
| image_class = skin-invert-image
| width = 275

<!--Clinical data-->| tradename = 
| Drugs.com = {{drugs.com|international|denopamine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Rx-only <small>([JP](/source/Japan))</small>
| routes_of_administration = [By mouth](/source/By_mouth)

<!--Pharmacokinetic data-->| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = <!--Identifiers-->
| CAS_number = 71771-90-9
| ATC_prefix = none
| ATC_suffix = 
| ATC_supplemental = 
| PubChem = 71754
| ChEMBL = 493682
| IUPHAR_ligand = 534
| DrugBank = 
| ChemSpiderID = 64795
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = V5F60UPD8P
| KEGG = D02614

<!--Chemical data-->| chemical_formula = 
| C = 18
| H = 23
| N = 1
| O = 4
| smiles = O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C
}}

'''Denopamine''' ([INN](/source/International_Nonproprietary_Name)) is a drug which acts as a [β<sub>1</sub> adrenergic receptor](/source/Beta-1_adrenergic_receptor) [agonist](/source/agonist).<ref>{{cite journal | vauthors = Ishide T | title = Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator | journal = Current Medical Research and Opinion | volume = 18 | issue = 7 | pages = 407–13 | year = 2002 | pmid = 12487507 | doi = 10.1185/030079902125001119 | s2cid = 25048757 }}</ref> It is used in the treatment of [angina](/source/angina)<ref>{{cite journal | vauthors = Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T | display-authors = 6 | title = Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment | journal = International Journal of Cardiology | volume = 108 | issue = 2 | pages = 281–3 | date = April 2006 | pmid = 15913812 | doi = 10.1016/j.ijcard.2005.03.012 }}</ref> and may also have potential uses in the treatment of [congestive heart failure](/source/Heart_failure)<ref>{{cite journal | vauthors = Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S | title = Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart | journal = Journal of the American College of Cardiology | volume = 32 | issue = 3 | pages = 808–15 | date = September 1998 | pmid = 9741531 | doi = 10.1016/S0735-1097(98)00314-3 | hdl = 2433/181223 | hdl-access = free }}</ref> and for clearing [pulmonary edema](/source/pulmonary_edema).<ref>{{cite journal | vauthors = Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y | display-authors = 6 | title = Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs | journal = Japanese Journal of Pharmacology | volume = 85 | issue = 2 | pages = 161–6 | date = February 2001 | pmid = 11286398 | doi = 10.1254/jjp.85.161 | doi-access = free }}</ref> It is marketed in Japan under the brand name '''Kalgut''' and available as tablets of 5 and 10&nbsp;mg, and 5% fine granules.<ref>{{cite web|title=Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information|url=https://medical.mt-pharma.co.jp/di/file/dc/kal.pdf|publisher=Mitsubishi Tanabe Pharma Corporation|access-date=6 March 2016|language=Japanese}}</ref>

== References ==
{{reflist|2}}

{{Cardiac stimulants excluding cardiac glycosides}}
{{Adrenergic receptor modulators}}

Category:Beta1-adrenergic agonists
Category:Phenylethanolamines
Category:Catechol ethers
Category:4-Hydroxyphenyl compounds

{{cardiovascular-drug-stub}}

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Adapted from the Wikipedia article [Denopamine](https://en.wikipedia.org/wiki/Denopamine) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Denopamine?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.