# Daf-12

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> Markdown URL: https://mediated.wiki/source/Daf-12.md
> Source: https://en.wikipedia.org/wiki/Daf-12
> Source revision: 1337362619
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{{Infobox nonhuman protein
| Name = Nuclear hormone receptor family member daf-12
| image = 
| width = 
| caption = 
| Organism = Caenorhabditis elegans
| TaxID = 6239
| Symbol = daf-12
| AltSymbols = NR1J1
| EntrezGene = 181263
| HomoloGene = 
| PDB = 
| RefSeqmRNA = NM_001029376.5
| RefSeqProtein = NP_001024547.1
| UniProt = G5EFF5
| Chromosome = X
| EntrezChromosome = NC_003284.9
| GenLoc_start = 10641038
| GenLoc_end = 10670243
}}

The '''DAF-12''' (abnormal dauer formation protein 12) [gene](/source/gene) encodes the [nuclear receptor](/source/nuclear_receptor) of [dafachronic acid](/source/dafachronic_acid) (a [steroid](/source/steroid) [hormone](/source/hormone)) in the worm ''[Caenorhabditis elegans](/source/Caenorhabditis_elegans)'', with the NRNC Symbol '''NR1J1''' as the homolog of nuclear hormone receptor HR96 ([https://www.uniprot.org/uniprot/Q24143 ''Hr96'']) in [Drosophila melanogaster](/source/Drosophila_melanogaster).<ref name="Kaur_2015">{{cite journal | vauthors = Kaur S, Jobling S, Jones CS, Noble LR, Routledge EJ, Lockyer AE | title = The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms | journal = [PLOS ONE](/source/PLOS_ONE) | volume = 10 | issue = 4 | article-number = e0121259 | date = 7 April 2015 | pmid = 25849443 | pmc = 4388693 | doi = 10.1371/journal.pone.0121259 | doi-access = free | bibcode = 2015PLoSO..1021259K }}</ref> DAF-12 has been implicated by [Cynthia Kenyon](/source/Cynthia_Kenyon) and colleagues in the formation of [Dauer larva](/source/Dauer_larva).<ref name="Kenyon_1993">{{cite journal |vauthors=Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R | title=A C. elegans mutant that lives twice as long as wild type | journal=[Nature](/source/Nature_(journal)) | volume=366 | issue=6454 | year=1993 | pages=461–464 | pmid=8247153 | doi=10.1038/366461a0| bibcode=1993Natur.366..461K | s2cid=4332206 }}</ref>

In favorable environments, a [cytochrome p450](/source/cytochrome_p450) [Daf-9](/source/Daf-9) (Cyp22a1)<ref name="Jia_2002">{{cite journal | vauthors = Jia K, Albert PS, Riddle DL| title = DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity | journal = [Development](/source/Development_(journal)) | volume = 129 | issue = 1 | pages = 221–31 | date = 2002 | doi = 10.1242/dev.129.1.221 | pmid = 11782415 }}</ref> produce dafachronic acid to binding Daf-12 to initiating downstream gene expression.<ref name="Aguilaniu_2016">{{cite journal|author1-link=Hugo Aguilaniu | vauthors = Aguilaniu H, Fabrizio P, Witting M | title = The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry | journal = [Frontiers in Endocrinology](/source/Frontiers_in_Endocrinology) | volume = 7 | page = 12 | date = 2016 | pmid = 26903948 | pmc = 4749721 | doi = 10.3389/fendo.2016.00012 | doi-access = free }}</ref> When in unfavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-[repressor](/source/repressor) [DIN-1](/source/DIN-1).<ref name="Bento_2010">{{cite journal | vauthors = Bento G, Ogawa A, Sommer RJ | title = Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution | journal = [Nature](/source/Nature_(journal)) | volume = 466 | issue = 7305 | pages = 494–7 | date = July 2010 | pmid = 20592728 | doi = 10.1038/nature09164 | bibcode = 2010Natur.466..494B | s2cid = 4405326 }}</ref>

== References ==
{{Reflist}}

{{Dauer larva}}

Category:Caenorhabditis elegans genes
1

{{Genetics-stub}}

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