# DPP8

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> Source: https://en.wikipedia.org/wiki/DPP8
> Source revision: 1301008598
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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
'''Dipeptidyl peptidase 8''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''DPP8'' [gene](/source/gene).<ref name="pmid11012666">{{cite journal | vauthors = Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD |authorlink4=Grant Robert Sutherland | title = Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8 | journal = Eur J Biochem | volume = 267 | issue = 20 | pages = 6140–50 |date=Nov 2000 | pmid = 11012666 | doi =10.1046/j.1432-1327.2000.01617.x  | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DPP8 dipeptidyl-peptidase 8| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54878}}</ref>

This gene encodes a member of the [peptidase](/source/peptidase) S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a [prolyl](/source/prolyl) bond. The encoded protein shares similarity with [dipeptidyl peptidase-4](/source/dipeptidyl_peptidase-4) in that it is ubiquitously expressed, and [hydrolyzes](/source/hydrolyzes) the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in [T-cell](/source/T-cell) activation and immune function. Alternatively spliced transcript variants encoding different [isoforms](/source/isoforms) have been described.<ref name="entrez" /> A relatively specific inhibitor of DPP8 and [DPP9](/source/DPP9), Val-boroPro <ref>{{cite web | title = PubChem:Val-boroPro| url = https://pubchem.ncbi.nlm.nih.gov/#query=Val-boroPro}}</ref>-,<ref name="pmid29396289">{{cite journal | vauthors = Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA | title = Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome | journal = Cell Chemical Biology | volume = 25 | issue = 3 | pages = 262–267.e5 | date = March 2018 | pmid = 29396289 | pmc = 5856610 | doi = 10.1016/j.chembiol.2017.12.013 | url = }}</ref> leads to increased activation of the [inflammasome](/source/inflammasome) though both NLRBP1 and [CARD8](/source/CARD8) and can trigger [pyroptosis](/source/pyroptosis).<ref name="pmid29967349">{{cite journal | vauthors = Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA | title = DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia | journal = Nature Medicine | volume = 24 | issue = 8 | pages = 1151–1156 | date = August 2018 | pmid = 29967349 | pmc = 6082709 | doi = 10.1038/s41591-018-0082-y | url = }}</ref>

==References==
;Notes
{{reflist}}

;Further reading
{{refbegin | 2}}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Ajami K |title=Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family |journal=Biochemistry |volume=42 |issue= 3 |pages= 694–701 |year= 2003 |pmid= 12534281 |doi= 10.1021/bi026846s  |name-list-style=vanc| author2=Abbott CA  | author3=Obradovic M  | display-authors=3  | last4=Gysbers  | first4=Vanessa  | last5=Kähne  | first5=Thilo  | last6=McCaughan  | first6=Geoffrey W.  | last7=Gorrell  | first7=Mark D. }}
*{{cite journal  | author=Qi SY |title=Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 179–89 |year= 2003 |pmid= 12662155 |doi= 10.1042/BJ20021914  | pmc=1223468  |name-list-style=vanc| author2=Riviere PJ  | author3=Trojnar J  | display-authors=3  | last4=Junien  | first4=Jean-Louis  | last5=Akinsanya  | first5=Karen O. }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-style=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
*{{cite journal  | author=Shu H |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line |journal=Mol. Cell. Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200  |name-list-style=vanc| author2=Chen S  | author3=Bi Q  | display-authors=3  | last4=Mumby  | first4=M  | last5=Brekken  | first5=DL |doi-access=free }}
*{{cite journal  | author=Chen YS |title=Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells |journal=Protein Expr. Purif. |volume=35 |issue= 1 |pages= 142–6 |year= 2004 |pmid= 15039077 |doi= 10.1016/j.pep.2003.12.019  |name-list-style=vanc| author2=Chien CH  | author3=Goparaju CM  | display-authors=3  | last4=Hsu  | first4=JT  | last5=Liang  | first5=PH  | last6=Chen  | first6=X }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Jiaang WT |title=Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 |journal=Bioorg. Med. Chem. Lett. |volume=15 |issue= 3 |pages= 687–91 |year= 2005 |pmid= 15664838 |doi= 10.1016/j.bmcl.2004.11.023  |name-list-style=vanc| author2=Chen YS  | author3=Hsu T  | display-authors=3  | last4=Wu  | first4=Ssu-Hui  | last5=Chien  | first5=Chia-Hui  | last6=Chang  | first6=Chung-Nien  | last7=Chang  | first7=Sheng-Ping  | last8=Lee  | first8=Shiow-Ju  | last9=Chen  | first9=Xin }}
*{{cite journal  | author=Ogasawara W |title=Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli |journal=Protein Expr. Purif. |volume=41 |issue= 2 |pages= 241–51 |year= 2005 |pmid= 15866709 |doi= 10.1016/j.pep.2004.10.027  |name-list-style=vanc| author2=Tanaka C  | author3=Suzuki M  | display-authors=3  | last4=Kobayashi  | first4=G  | last5=Ogawa  | first5=Y  | last6=Okada  | first6=H  | last7=Morikawa  | first7=Y }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-style=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite book  | author=Yu DM |volume=575 |pages= 63–72 |year= 2006 |pmid= 16700509 |doi=10.1007/0-387-32824-6_7  |name-list-style=vanc| author2=Wang XM  | author3=Ajami K  | display-authors=3  | series=Advances in Experimental Medicine and Biology  | last4=McCaughan  | first4=Geoffrey W.  | last5=Gorrell  | first5=Mark D.  |title=Dipeptidyl Aminopeptidases |chapter=DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis | isbn=978-0-387-29058-4  }}
*{{cite journal  | vauthors=Yu DM, Wang XM, McCaughan GW, Gorrell MD |title=Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis |journal=FEBS J. |volume=273 |issue= 11 |pages= 2447–60 |year= 2006 |pmid= 16704418 |doi= 10.1111/j.1742-4658.2006.05253.x |doi-access= free }}
*{{cite journal  | author=Lee HJ |title=Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8 |journal=J. Biol. Chem. |volume=281 |issue= 50 |pages= 38653–62 |year= 2007 |pmid= 17040910 |doi= 10.1074/jbc.M603895200  |name-list-style=vanc| author2=Chen YS  | author3=Chou CY  | display-authors=3  | last4=Chien  | first4=C.-H.  | last5=Lin  | first5=C.-H.  | last6=Chang  | first6=G.-G.  | last7=Chen  | first7=X. | doi-access=free  }}
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Adapted from the Wikipedia article [DPP8](https://en.wikipedia.org/wiki/DPP8) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DPP8?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.