# DPHP

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> Markdown URL: https://mediated.wiki/source/DPHP.md
> Source: https://en.wikipedia.org/wiki/DPHP
> Source revision: 1301402925
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Chembox
| ImageFile = DPHP.svg
| ImageAlt = 
| PIN = Bis(2-propylheptyl) benzene-1,2-dicarboxylate
| OtherNames = Bis(2-propylheptyl) phthalate
|Section1={{Chembox Identifiers
| CASNo = 53306-54-0
| PubChem = 92344
| ChemSpiderID = 83367
| EC_number = 258-469-4
| SMILES = CCCCCC(CCC)COC(=O)c1ccccc1C(=O)OCC(CCC)CCCCC
| StdInChI=1S/C28H46O4/c1-5-9-11-17-23(15-7-3)21-31-27(29)25-19-13-14-20-26(25)28(30)32-22-24(16-8-4)18-12-10-6-2/h13-14,19-20,23-24H,5-12,15-18,21-22H2,1-4H3
| StdInChIKey = MTYUOIVEVPTXFX-UHFFFAOYSA-N
  }}
|Section2={{Chembox Properties
| C=28 | H=46 | O=4
| Appearance = Clear oily liquid<ref name=basf>{{cite web | url = http://www.plasticizers.basf.com/portal/streamer?fid=293114 | title = Palatinol DPHP Technical Information | publisher = basf.com }}</ref>
| Density = 0.957-0.965 g/cm<sup>3</sup><ref name=basf/>
| MeltingPt = 
| BoilingPt = 
| Solubility = < 0.01 mg/L<ref name=basf/>
| Viscosity = 120-130 mPas
| RefractIndex = 1.482-1.484
  }}
|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
  }}
}}

'''Di(2-propylheptyl) phthalate''' (also known as '''bis(2-propylheptyl) benzene-1,2-dicarboxylate''', '''di(propylheptyl) orthophthalate''', or '''DPHP''') is an [organic compound](/source/organic_compound) with the formula C<sub>28</sub>H<sub>46</sub>O<sub>4</sub>. It is a [phthalate](/source/phthalate) and is the diester of [phthalic acid](/source/phthalic_acid) and the 10-carbon branched-chain alcohol [2-propylheptanol](/source/2-Propylheptanol).<ref>{{Cite web |title=Bis(2-propylheptyl) phthalate CAS 53306-54-0 DPHP - Buy Bis(2-propylheptyl) phthalate, 53306-54-0, DPHP Product on BOSS CHEMICAL |url=https://www.bosschemical.com/bis-2-propylheptyl-phthalate-cas-53306-54-0-dphp.html |access-date=2025-06-05 |website=www.bosschemical.com}}</ref> This colorless, viscous liquid is used for softening [PVC](/source/Polyvinyl_chloride) plastics and is a general purpose PVC [plasticizer](/source/plasticizer).<ref>{{cite web | url = http://phthalates.americanchemistry.com/Industry/Regulatory-Reviews/DPHP.html | title = DPHP | publisher = [American Chemistry Council](/source/American_Chemistry_Council)}}</ref> It possesses very good plasticizing properties and may be used as a direct replacement for [DEHP](/source/DEHP) and [DINP](/source/DINP) in many applications.<ref>{{Cite web |title=Dipropylheptyl phthalate Supplier {{!}} 53306-54-0 {{!}} Your Reliable Distributor Silver Fern |url=https://www.silverfernchemical.com/chemical-supplier-53306-54-0/dipropylheptyl-phthalate-distributor-63.aspx |access-date=2025-06-05 |website=Silver Fern Chemical Inc. |language=en}}</ref>

== History of discovery ==
{{See also|Phthalates|Bis(2-propylheptyl) phthalate}}
The introduction of Di(2-propylheptyl) phthalate (DPHP) was driven by increasing regulatory scrutiny and health concerns associated with [traditional plasticizers](/source/Plasticizer).<ref name=":0">{{Cite web |title=Plasticizer - Di(2-Propyl Heptyl) Phthalate- Zhejiang Great Chemical Science & Technology Co., Ltd. |url=https://www.gst-chem.com/news/plasticizer-di-2propyl-heptyl-phthalate.html |access-date=2025-06-05 |website=www.gst-chem.com}}</ref>

DPHP was developed to meet the demand for [plasticizers](/source/Plasticizer) with improved safety profiles, particularly in applications involving human contact. As a result of its production through the [esterification](/source/Ester) of [phthalic anhydride](/source/phthalic_anhydride) with [2-propylheptanol](/source/2-Propylheptanol), it results in a compound with low volatility and high thermal stability, making it suitable for various applications, including automotive interiors, wire and cable insulation, and flooring materials.<ref>{{Cite web |title=DPHP-Di-2-Propylheptyl-Phthalate |url=https://www.npc.com.tw/j2npc/enus/prod/Chemicals/Phthalate-Plasticizers/DPHP-Di-(2-Propylheptyl)%20Phthalate |access-date=2025-06-05 |website=www.npc.com.tw}}</ref>

The compound gained regulatory attention in the [European Union](/source/European_Union), where it was included in the Community Rolling Action Plan (CoRAP) under the [REACH regulation](/source/Registration%2C_Evaluation%2C_Authorisation_and_Restriction_of_Chemicals) in 2014. This inclusion was due to concerns about its widespread use, potential [endocrine-disrupting](/source/Endocrine_disruptor) properties, and exposure risks to sensitive populations. Germany was tasked with evaluating DPHP's health and environmental impacts, with the assessment process beginning in 2020.<ref name=":0" />

Research into DPHP's metabolism and exposure markers has been conducted to better understand its behavior in biological systems. A 2019 study utilized [ultra-performance liquid chromatography-mass spectrometry](/source/High-performance_liquid_chromatography) (UPLC-MS) in a rat model to identify potential [biomarkers](/source/Biomarker) for DPHP exposure, aiding in the assessment of human exposure levels.<ref>{{Cite journal |last1=Chia-Lung |first1=Shih |last2=Jen-Yi |first2=Hsu |last3=Chien-Ping |first3=Tien |last4=Yi-Ning |first4=Chung |last5=G. |first5=Zgoda, Victor |last6=Pao-Chi |first6=Liao |date=2019 |title=Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model |url=https://agris.fao.org/search/en/providers/122535/records/65e002ee63b8185d9cb099cc |journal=Yàowù shípǐn fēnxī |language=en |issn=1021-9498 |archive-url=https://web.archive.org/web/20250419040333/https://agris.fao.org/search/en/providers/122535/records/65e002ee63b8185d9cb099cc |archive-date=2025-04-19 |access-date=2025-06-05 |url-status=live }}</ref><ref>{{Cite web |title=Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectromet… |url=http://ouci.dntb.gov.ua/en/works/ldMBWR09/ |access-date=2025-06-05 |website=ouci.dntb.gov.ua |language=en}}</ref><ref>{{Cite journal |last1=Shih |first1=Chia-Lung |last2=Hsu |first2=Jen-Yi |last3=Tien |first3=Chien-Ping |last4=Chung |first4=Yi-Ning |last5=Zgoda |first5=Victor G. |last6=Liao |first6=Pao-Chi |date=April 2019 |title=Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model |journal=Journal of Food and Drug Analysis |volume=27 |issue=2 |pages=585–594 |doi=10.1016/j.jfda.2018.11.002 |issn=2224-6614 |pmc=9296194 |pmid=30987730}}</ref>

==References==
{{reflist}}

Category:Phthalate esters

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Adapted from the Wikipedia article [DPHP](https://en.wikipedia.org/wiki/DPHP) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DPHP?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.