# DOK1

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> Markdown URL: https://mediated.wiki/source/DOK1.md
> Source: https://en.wikipedia.org/wiki/DOK1
> Source revision: 1301318964
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Docking protein 1''' is a [protein](/source/protein) that in humans is encoded by the ''DOK1'' [gene](/source/gene).<ref name="pmid9008160">{{cite journal | vauthors = Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B | title = p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells | journal = Cell | volume = 88 | issue = 2 | pages = 197–204  | date = February 1997 | pmid = 9008160 | doi = 10.1016/S0092-8674(00)81840-1 | s2cid = 16781519 | doi-access = free }}</ref><ref name="pmid9790776">{{cite journal | vauthors = Nelms K, Snow AJ, Noben-Trauth K | title = Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia | journal = Genomics | volume = 53 | issue = 2 | pages = 243–5  | date = December 1998 | pmid = 9790776 | doi = 10.1006/geno.1998.5514 | url = https://zenodo.org/record/1229765 }}</ref><ref name="pmid15546884">{{cite journal | vauthors = Ling Y, Maile LA, Badley-Clarke J, Clemmons DR | title = DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells | journal = J. Biol. Chem. | volume = 280 | issue = 5 | pages = 3151–8  | date = February 2005 | pmid = 15546884 | doi = 10.1074/jbc.M411035200 | doi-access = free }}</ref>

== Function ==

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase.  It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML.  Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.  Docking protein 2 binds p120 (RasGAP) from CML cells.  It has been postulated to play a role in mitogenic signaling.<ref name="entrez">{{cite web | title = Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1796}}</ref>

== Interactions ==

DOK1 has been shown to [interact](/source/Protein-protein_interaction) with:
{{div col|colwidth=20em}}
* [ABL1](/source/Abl_gene)<ref name = pmid11071635/><ref name = pmid9008161/> and 
* [CD117](/source/CD117),<ref name = pmid11825908/> 
* [INPP5D](/source/INPP5D),<ref name = pmid11071635/><ref name = pmid10822173/> 
* [LYN](/source/LYN),<ref name = pmid11071635>{{cite journal | vauthors = van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M | title = Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells | journal = Blood | volume = 96 | issue = 10 | pages = 3406–13  | date = November 2000 | pmid = 11071635 | doi =  10.1182/blood.V96.10.3406| url = https://pure.eur.nl/en/publications/395fb5fc-60e3-45d7-a9b1-fc7b9cc6b4bc | hdl = 1765/9530 | hdl-access = free }}</ref><ref name = pmid11825908>{{cite journal | vauthors = Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD | title = Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13732–8  | date = April 2002 | pmid = 11825908 | doi = 10.1074/jbc.M200277200 | doi-access = free }}</ref> 
* [RASA1](/source/RAS_p21_protein_activator_1),<ref name = pmid9008161>{{cite journal | vauthors = Yamanashi Y, Baltimore D | title = Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok | journal = Cell | volume = 88 | issue = 2 | pages = 205–11  | date = January 1997 | pmid = 9008161 | doi = 10.1016/s0092-8674(00)81841-3 | s2cid = 14205526 | doi-access = free }}</ref><ref name = pmid10822173>{{cite journal | vauthors = Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD | title = The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells | journal = Cell. Signal. | volume = 12 | issue = 5 | pages = 317–26  | date = May 2000 | pmid = 10822173 | doi = 10.1016/s0898-6568(00)00073-5 }}</ref><ref name = pmid10799545>{{cite journal | vauthors = Némorin JG, Duplay P | title = Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling | journal = J. Biol. Chem. | volume = 275 | issue = 19 | pages = 14590–7  | date = May 2000 | pmid = 10799545 | doi = 10.1074/jbc.275.19.14590 | doi-access = free }}</ref> 
* [RET](/source/RET_proto-oncogene),<ref name = pmid12087092>{{cite journal | vauthors = Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M | title = Role of Dok1 in cell signaling mediated by RET tyrosine kinase | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32781–90  | date = September 2002 | pmid = 12087092 | doi = 10.1074/jbc.M202336200 | doi-access = free }}</ref> 
* [SH2D1A](/source/SH2D1A),<ref name = pmid10852966>{{cite journal | vauthors = Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E | title = The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 13 | pages = 7470–5  | date = June 2000 | pmid = 10852966 | pmc = 16569 | doi = 10.1073/pnas.130193097 | bibcode = 2000PNAS...97.7470S | doi-access = free }}</ref> 
* [SHC1](/source/SHC1),<ref name = pmid10822173/>  and
* [TEC](/source/TEC_(gene)).<ref name = pmid11071635/><ref name = pmid11825908/>
{{Div col end}}

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Wisniewski D, Strife A, Wojciechowicz D, Lambek C, Clarkson B | title = A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations | journal = Leukemia | volume = 8 | issue = 4 | pages = 688–93 | year = 1994 | pmid = 8152267 }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yamanashi Y, Baltimore D | title = Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok | journal = Cell | volume = 88 | issue = 2 | pages = 205–11 | year = 1997 | pmid = 9008161 | doi = 10.1016/S0092-8674(00)81841-3 | s2cid = 14205526 | doi-access = free }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = Vuica M, Desiderio S, Schneck JP | title = Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62 | journal = J. Exp. Med. | volume = 186 | issue = 2 | pages = 259–67 | year = 1997 | pmid = 9221755 | pmc = 2198989 | doi = 10.1084/jem.186.2.259 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W | title = Identification of Nck family genes, chromosomal localization, expression, and signaling specificity | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25171–8 | year = 1998 | pmid = 9737977 | doi = 10.1074/jbc.273.39.25171 | doi-access = free }}
* {{cite journal | vauthors = Noguchi T, Matozaki T, Inagaki K, Tsuda M, Fukunaga K, Kitamura Y, Kitamura T, Shii K, Yamanashi Y, Kasuga M | title = Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration | journal = EMBO J. | volume = 18 | issue = 7 | pages = 1748–60 | year = 1999 | pmid = 10202139 | pmc = 1171261 | doi = 10.1093/emboj/18.7.1748 }}
* {{cite journal | vauthors = Cong F, Yuan B, Goff SP | title = Characterization of a novel member of the DOK family that binds and modulates Abl signaling | journal = Mol. Cell. Biol. | volume = 19 | issue = 12 | pages = 8314–25 | year = 1999 | pmid = 10567556 | pmc = 84915 | doi =  10.1128/MCB.19.12.8314}}
* {{cite journal | vauthors = Berg KL, Siminovitch KA, Stanley ER | title = SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35855–65 | year = 1999 | pmid = 10585470 | doi = 10.1074/jbc.274.50.35855 | doi-access = free }}
* {{cite journal | vauthors = Becker E, Huynh-Do U, Holland S, Pawson T, Daniel TO, Skolnik EY | title = Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation | journal = Mol. Cell. Biol. | volume = 20 | issue = 5 | pages = 1537–45 | year = 2000 | pmid = 10669731 | pmc = 85333 | doi = 10.1128/MCB.20.5.1537-1545.2000 }}
* {{cite journal | vauthors = Némorin JG, Duplay P | title = Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling | journal = J. Biol. Chem. | volume = 275 | issue = 19 | pages = 14590–7 | year = 2000 | pmid = 10799545 | doi = 10.1074/jbc.275.19.14590 | doi-access = free }}
* {{cite journal | vauthors = Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD | title = The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells | journal = Cell. Signal. | volume = 12 | issue = 5 | pages = 317–26 | year = 2000 | pmid = 10822173 | doi = 10.1016/S0898-6568(00)00073-5 }}
* {{cite journal | vauthors = Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, Shimada K, Yamanaka T, Ozawa K, Mano H | title = Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1 | journal = J. Biol. Chem. | volume = 275 | issue = 32 | pages = 24945–52 | year = 2000 | pmid = 10823839 | doi = 10.1074/jbc.M909012199 | doi-access =free  }}
* {{cite journal | vauthors = Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E | title = The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 13 | pages = 7470–5 | year = 2000 | pmid = 10852966 | pmc = 16569 | doi = 10.1073/pnas.130193097 | bibcode = 2000PNAS...97.7470S | doi-access = free }}
* {{cite journal | vauthors = Hubert P, Ferreira V, Debre P, Bismuth G | title = Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del) | journal = Eur. J. Immunogenet. | volume = 27 | issue = 3 | pages = 145–8 | year = 2000 | pmid = 10940083 | doi = 10.1046/j.1365-2370.2000.00203.x }}
* {{cite journal | vauthors = Songyang Z, Yamanashi Y, Liu D, Baltimore D | title = Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling | journal = J. Biol. Chem. | volume = 276 | issue = 4 | pages = 2459–65 | year = 2001 | pmid = 11042170 | doi = 10.1074/jbc.M005504200 | s2cid = 9752201 | url = https://authors.library.caltech.edu/9776/1/SONjbc01.pdf | doi-access = free }}
{{refend}}

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Adapted from the Wikipedia article [DOK1](https://en.wikipedia.org/wiki/DOK1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DOK1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.