# DOC2A

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> Source: https://en.wikipedia.org/wiki/DOC2A
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Double C2-like domain-containing protein alpha''' is a [protein](/source/protein) that in humans is encoded by the ''DOC2A'' [gene](/source/gene).<ref name="pmid7826360">{{cite journal | vauthors = Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y | title = Doc2: a novel brain protein having two repeated C2-like domains | journal = Biochem Biophys Res Commun | volume = 206 | issue = 2 | pages = 439–48 |date=Feb 1995 | pmid = 7826360 | doi = 10.1006/bbrc.1995.1062 }}</ref><ref name="pmid9736751">{{cite journal | vauthors = Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y | title = Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11418–22 |date=Oct 1998 | pmid = 9736751 | pmc = 21657 | doi =10.1073/pnas.95.19.11418  | bibcode = 1998PNAS...9511418M | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DOC2A double C2-like domains, alpha| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8448}}</ref>

There are at least two protein isoforms of the Double C2 protein,  namely alpha (DOC2A) and beta ([DOC2B](/source/DOC2B)), which contain two [C2-like domains](/source/C2_domain).  DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca<sup>2+</sup>-dependent neurotransmitter release.<ref name="entrez" />

== Interactions ==

DOC2A has been shown to [interact](/source/Protein-protein_interaction) with [UNC13B](/source/UNC13B)<ref name="pmid9736751"/><ref name="pmid9195900">{{cite journal | vauthors = Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y | title = Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16081–4 |date=June 1997 | pmid = 9195900 | doi = 10.1074/jbc.272.26.16081  | doi-access = free }}</ref> and [UNC13A](/source/UNC13A).<ref>{{cite web|title=Protein unc-13 homolog A|url=https://www.uniprot.org/uniprot/Q9UPW8|website=UniProt}}</ref>

== References ==
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==Further reading==
{{refbegin | 2}}
* {{cite journal | vauthors = Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y | title = Molecular cloning of an isoform of Doc2 having two C2-like domains | journal = Biochem. Biophys. Res. Commun. | volume = 217 | issue = 3 | pages = 1053–61 |date=December 1995 | pmid = 8554557 | doi = 10.1006/bbrc.1995.2876}}
* {{cite journal | vauthors = Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC | title = DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion | journal = Neuron | volume = 18 | issue = 3 | pages = 453–61 |date=March 1997 | pmid = 9115738 | doi = 10.1016/S0896-6273(00)81245-3 | s2cid = 17948539 | doi-access = free }}
* {{cite journal | vauthors = Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y | title = Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport | journal = J. Biol. Chem. | volume = 273 | issue = 46 | pages = 30065–8 |date=November 1998 | pmid = 9804756 | doi = 10.1074/jbc.273.46.30065 | doi-access = free }}
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Adapted from the Wikipedia article [DOC2A](https://en.wikipedia.org/wiki/DOC2A) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DOC2A?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.