# DNAJC7

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Protein-coding gene in the species Homo sapiens

DNAJC7 Identifiers Aliases DNAJC7, DJ11, DJC7, TPR2, TTC2, DnaJ heat shock protein family (Hsp40) member C7 External IDs OMIM: 601964; MGI: 1928373; HomoloGene: 68306; GeneCards: DNAJC7; OMA:DNAJC7 - orthologs Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,976,421 bp[1] End 42,021,376 bp[1] Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.47 cM Start 100,473,644 bp[2] End 100,511,014 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus right frontal lobe anterior pituitary monocyte mucosa of transverse colon apex of heart cingulate gyrus Brodmann area 9 anterior cingulate cortex Top expressed in tail of embryo neural layer of retina ventricular zone genital tubercle superior frontal gyrus thymus ganglionic eminence cerebellar cortex primary visual cortex trigeminal ganglion More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding heat shock protein binding ATPase activator activity Cellular component cytoplasm extracellular exosome cytoskeleton membrane nucleus nucleoplasm cytosol Biological process regulation of cellular response to heat protein folding positive regulation of ATP-dependent activity chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 7266 56354 Ensembl ENSG00000168259 ENSMUSG00000014195 UniProt Q99615 Q9QYI3 RefSeq (mRNA) NM_001144766 NM_003315 NM_019795 NM_001378962 NM_001378963 RefSeq (protein) NP_001138238 NP_003306 NP_062769 NP_001365891 NP_001365892 Location (UCSC) Chr 17: 41.98 – 42.02 Mb Chr 11: 100.47 – 100.51 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**DnaJ homolog subfamily C member 7** is a [protein](/source/Protein) that in humans is encoded by the *DNAJC7* [gene](/source/Gene).[5][6][7]

## Interactions

DNAJC7 has been shown to [interact](/source/Protein-protein_interaction) with [RAD9A](/source/RAD9A).[8]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000168259](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000168259) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000014195](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000014195) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7266). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=56354). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid8836031_5-0)** Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". *DNA Cell Biol*. **15** (9): 727–35. [doi](/source/Doi_(identifier)):[10.1089/dna.1996.15.727](https://doi.org/10.1089%2Fdna.1996.15.727). [PMID](/source/PMID_(identifier)) [8836031](https://pubmed.ncbi.nlm.nih.gov/8836031).

1. **[^](#cite_ref-pmid11147971_6-0)** Ohtsuka K, Hata M (Jan 2001). ["Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312896). *Cell Stress Chaperones*. **5** (2): 98–112. [doi](/source/Doi_(identifier)):[10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2](https://doi.org/10.1379%2F1466-1268%282000%29005%3C0098%3Amhdhco%3E2.0.co%3B2) (inactive 12 July 2025). [PMC](/source/PMC_(identifier)) [312896](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312896). [PMID](/source/PMID_(identifier)) [11147971](https://pubmed.ncbi.nlm.nih.gov/11147971).{{[cite journal](https://en.wikipedia.org/wiki/Template:Cite_journal)}}: CS1 maint: DOI inactive as of July 2025 ([link](https://en.wikipedia.org/wiki/Category:CS1_maint:_DOI_inactive_as_of_July_2025))

1. **[^](#cite_ref-entrez_7-0)** ["Entrez Gene: DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7266).

1. **[^](#cite_ref-pmid11573955_8-0)** Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC (2001). ["The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9"](https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27371&item_no=1&attribute_id=26&file_no=1). *Biochem. Biophys. Res. Commun*. **287** (4): 932–40. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2001.5685](https://doi.org/10.1006%2Fbbrc.2001.5685). [hdl](/source/Hdl_(identifier)):[2297/1794](https://hdl.handle.net/2297%2F1794). [PMID](/source/PMID_(identifier)) [11573955](https://pubmed.ncbi.nlm.nih.gov/11573955). [S2CID](/source/S2CID_(identifier)) [20694221](https://api.semanticscholar.org/CorpusID:20694221).

## Further reading

- Hartley JL, Temple GF, Brasch MA (2001). ["DNA Cloning Using In Vitro Site-Specific Recombination"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948). *Genome Res*. **10** (11): 1788–95. [doi](/source/Doi_(identifier)):[10.1101/gr.143000](https://doi.org/10.1101%2Fgr.143000). [PMC](/source/PMC_(identifier)) [310948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948). [PMID](/source/PMID_(identifier)) [11076863](https://pubmed.ncbi.nlm.nih.gov/11076863).

- Wiemann S, Weil B, Wellenreuther R, et al. (2001). ["Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). *Genome Res*. **11** (3): 422–35. [doi](/source/Doi_(identifier)):[10.1101/gr.GR1547R](https://doi.org/10.1101%2Fgr.GR1547R). [PMC](/source/PMC_(identifier)) [311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID](/source/PMID_(identifier)) [11230166](https://pubmed.ncbi.nlm.nih.gov/11230166).

- Xiang SL, Kumano T, Iwasaki SI, et al. (2001). ["The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9"](https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27371&item_no=1&attribute_id=26&file_no=1). *Biochem. Biophys. Res. Commun*. **287** (4): 932–40. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2001.5685](https://doi.org/10.1006%2Fbbrc.2001.5685). [hdl](/source/Hdl_(identifier)):[2297/1794](https://hdl.handle.net/2297%2F1794). [PMID](/source/PMID_(identifier)) [11573955](https://pubmed.ncbi.nlm.nih.gov/11573955). [S2CID](/source/S2CID_(identifier)) [20694221](https://api.semanticscholar.org/CorpusID:20694221).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Brychzy A, Rein T, Winklhofer KF, et al. (2003). ["Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165632). *EMBO J*. **22** (14): 3613–23. [doi](/source/Doi_(identifier)):[10.1093/emboj/cdg362](https://doi.org/10.1093%2Femboj%2Fcdg362). [PMC](/source/PMC_(identifier)) [165632](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165632). [PMID](/source/PMID_(identifier)) [12853476](https://pubmed.ncbi.nlm.nih.gov/12853476).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Wiemann S, Arlt D, Huber W, et al. (2004). ["From ORFeome to Biology: A Functional Genomics Pipeline"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930). *Genome Res*. **14** (10B): 2136–44. [doi](/source/Doi_(identifier)):[10.1101/gr.2576704](https://doi.org/10.1101%2Fgr.2576704). [PMC](/source/PMC_(identifier)) [528930](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930). [PMID](/source/PMID_(identifier)) [15489336](https://pubmed.ncbi.nlm.nih.gov/15489336).

- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". *Nat. Biotechnol*. **23** (1): 94–101. [doi](/source/Doi_(identifier)):[10.1038/nbt1046](https://doi.org/10.1038%2Fnbt1046). [PMID](/source/PMID_(identifier)) [15592455](https://pubmed.ncbi.nlm.nih.gov/15592455). [S2CID](/source/S2CID_(identifier)) [7200157](https://api.semanticscholar.org/CorpusID:7200157).

- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). ["The LIFEdb database in 2006"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501). *Nucleic Acids Res*. **34** (Database issue): D415–8. [doi](/source/Doi_(identifier)):[10.1093/nar/gkj139](https://doi.org/10.1093%2Fnar%2Fgkj139). [PMC](/source/PMC_(identifier)) [1347501](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501). [PMID](/source/PMID_(identifier)) [16381901](https://pubmed.ncbi.nlm.nih.gov/16381901).

v t e Posttranslational modification Chaperones/ protein folding Heat shock proteins/ Chaperonins Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α1 α2 β ER TRAP1 Other Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2 Protein targeting Signal peptide Mitochondrial targeting signal Ubiquitin (ubiquitylation) E1 Ubiquitin-activating enzyme UBA1 UBA2 UBA3 UBA5 UBA6 UBA7 ATG7 NAE1 SAE1 E2 Ubiquitin-conjugating enzyme A B C D1 D2 D3 E1 E2 E3 G1 G2 H I J1 J2 K L1 L2 L3 L4 L6 M N O Q1 Q2 R1 (CDC34) R2 S V1 V2 Z E3 Ubiquitin ligase VHL Cullin CBL MDM2 FANCL UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein Category Commons

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Adapted from the Wikipedia article [DNAJC7](https://en.wikipedia.org/wiki/DNAJC7) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DNAJC7?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.