# DLX6-AS1

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/DLX6-AS1
> Markdown URL: https://mediated.wiki/source/DLX6-AS1.md
> Source: https://en.wikipedia.org/wiki/DLX6-AS1
> Source revision: 1317482374
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

**DLX6 antisense RNA 1** (DLX6-AS1) (**Evf-1** (Embryonic ventral forebrain-1)) is a developmentally-regulated [long non-coding RNA](/source/Long_non-coding_RNA). In [rats](/source/Rat), it is expressed in [neurons](/source/Neuron) in the subventricular zone of the developing [forebrain](/source/Forebrain). Its expression is linked to that of the [Shh](/source/Sonic_hedgehog) (sonic hedgehog) and [DLX](/source/DLX_gene_family) families of [genes](/source/Genes), which are important in ventral forebrain and [craniofacial](/source/Craniofacial) development.[1] An alternatively spliced form of DLX6-AS1, DLX6-AS2, forms a stable complex with the Dlx-2 protein. This complex activates transcription of Dlx-5 and Dlx-6.[2]

DLX6-AS2 regulates [gene expression](/source/Gene_expression) in a region of the brain which produces GABAergic [interneurons](/source/Interneurons) during development.[3] It is involved in the signaling pathway and works in conjunction with DLX [homeodomain proteins](/source/Homeodomain) to increase the effectiveness of the [Dlx5/6](/source/DLX_gene_family) enhancer element within neural [stem cells](/source/Stem_cell). The interneurons are found in the [hippocampus](/source/Hippocampus) of the adult brain, an area responsible for [learning](/source/Learning) and [memory](/source/Memory).[4]

GABAergic interneurons have been implicated in a number of [psychiatric disorders](/source/Psychiatric_disorders) including [autism](/source/Autism),[5] [schizophrenia](/source/Schizophrenia)[6] and [epilepsy](/source/Epilepsy);[7] as DLX6-AS2 controls the development of these neurons, it has been subject to studies regarding the causation of these disorders.[4]

DLX6-AS2 is the first known long non-coding RNA to be involved in [organogenesis](/source/Organogenesis).[8]

## See also

- [Long noncoding RNA](/source/Long_noncoding_RNA)
- [Dlx (gene)](/source/Dlx_(gene))
- [Gamma-Aminobutyric acid](/source/Gamma-Aminobutyric_acid)
- [Chemoaffinity hypothesis](/source/Chemoaffinity_hypothesis)

## References

1. Kohtz JD, Fishell G (July 2004). "Developmental regulation of EVF-1, a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene". *Gene Expr. Patterns*. **4** (4): 407–412. [doi:10.1016/j.modgep.2004.01.007](https://doi.org/10.1016/j.modgep.2004.01.007). [PMID 15183307](https://pubmed.ncbi.nlm.nih.gov/15183307)

1. Feng J, Bi C, Clark BS, Mady R, Shah P, Kohtz JD (June 2006). "The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator". *Genes Dev.*. **20** (11): 1470–1484. [doi:10.1101/gad.1416106](https://doi.org/10.1101/gad.1416106). [PMC 1475760](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475760). [PMID 16705037](https://pubmed.ncbi.nlm.nih.gov/16705037)

1. Sciencedaily (Sep 1, 2009). ["Non-Coding RNA Called Evf2 Is Important For Gene Regulation"](https://www.sciencedaily.com/releases/2009/08/090821163525.htm). Retrieved 26 July 2010.

1. Bond AM, Vangompel MJ, Sametsky EA (August 2009). "Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry". *Nat. Neurosci.*. **12** (8): 1020–1027. [doi:10.1038/nn.2371](https://doi.org/10.1038/nn.2371). [PMC 3203213](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203213). [PMID 19620975](https://pubmed.ncbi.nlm.nih.gov/19620975)

1. Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, Nelson SB (August 2005). "Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome". *Proc. Natl. Acad. Sci. U.S.A.*. **102** (35): 12560–12565. [Bibcode:2005PNAS..10212560D](https://ui.adsabs.harvard.edu/abs/2005PNAS..10212560D). [doi:10.1073/pnas.0506071102](https://doi.org/10.1073/pnas.0506071102). [PMC 1194957](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1194957). [PMID 16116096](https://pubmed.ncbi.nlm.nih.gov/16116096)

1. Lewis DA, Hashimoto T, Volk DW (April 2005). "Cortical inhibitory neurons and schizophrenia". *Nat. Rev. Neurosci.*. **6** (4): 312–324. [doi:10.1038/nrn1648](https://doi.org/10.1038/nrn1648). [PMID 15803162](https://pubmed.ncbi.nlm.nih.gov/15803162). [S2CID 3335493](https://api.semanticscholar.org/CorpusID:3335493)

1. Di Cristo G (July 2007). "Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders". *Clin. Genet.*. **72** (1): 1–8. [doi:10.1111/j.1399-0004.2007.00822.x](https://doi.org/10.1111/j.1399-0004.2007.00822.x). [PMID 17594392](https://pubmed.ncbi.nlm.nih.gov/17594392). [S2CID 22162349](https://api.semanticscholar.org/CorpusID:22162349)[dead link]

1. Shamovsky I, Nudler E (October 2006). "Gene control by large noncoding RNAs". *Sci. STKE*. **2006** (355): pe40. [doi:10.1126/stke.3552006pe40](https://doi.org/10.1126/stke.3552006pe40). [PMID 17018852](https://pubmed.ncbi.nlm.nih.gov/17018852). [S2CID 41151259](https://api.semanticscholar.org/CorpusID:41151259)

## Further reading

- Kohtz JD, Baker DP, Corte G, Fishell G (December 1998). ["Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog"](http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=9811591). *Development*. **125** (24): 5079–5089. [doi:10.1242/dev.125.24.5079](https://doi.org/10.1242/dev.125.24.5079). [PMID 9811591](https://pubmed.ncbi.nlm.nih.gov/9811591). Retrieved 2010-07-26.
- Ingham PW, McMahon AP (December 2001). "Hedgehog signaling in animal development: paradigms and principles". *Genes Dev.*. **15** (23): 3059–3087. [doi:10.1101/gad.938601](https://doi.org/10.1101/gad.938601). [PMID 11731473](https://pubmed.ncbi.nlm.nih.gov/11731473)
- Licastro D, Gennarino VA, Petrera F, Sanges R, Banfi S, Stupka E (2010). "Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements". *BMC Genomics*. **11**. [doi:10.1186/1471-2164-11-151](https://doi.org/10.1186/1471-2164-11-151). [PMC 2847969](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847969). [PMID 20202189](https://pubmed.ncbi.nlm.nih.gov/20202189)
- Erdmann VA, Barciszewska MZ, Hochberg A, de Groot N, Barciszewski J (June 2001). "Regulatory RNAs". *Cell. Mol. Life Sci.*. **58** (7): 960–977. [doi:10.1007/PL00000913](https://doi.org/10.1007/PL00000913). [PMC 11337372](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11337372). [PMID 11497242](https://pubmed.ncbi.nlm.nih.gov/11497242). [S2CID 19491637](https://api.semanticscholar.org/CorpusID:19491637)

---
Adapted from the Wikipedia article [DLX6-AS1](https://en.wikipedia.org/wiki/DLX6-AS1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DLX6-AS1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.