# DIS3
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> Source: https://en.wikipedia.org/wiki/DIS3
> Source revision: 1328789831
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Exosome complex exonuclease RRP44''' or '''Dis3''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''DIS3'' [gene](/source/gene).[{{cite journal | vauthors = Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, Haraldsson K, Johannsdottir HK, Vehmanen P, Nigam S, Golberger N, Robbins C, Pak E, Dutra A, Gillander E, Stephan DA, Bailey-Wilson J, Juo SH, Kainu T, Arason A, Barkardottir RB, Nevanlinna H, Borg A, Kallioniemi OP | title = A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes | journal = Hum Genet | volume = 110 | issue = 2 | pages = 111–21 |date=Apr 2002 | pmid = 11935316 | doi = 10.1007/s00439-001-0646-6 | s2cid = 21371347 | url = https://zenodo.org/record/1232709 }}][{{cite journal | vauthors = Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T | title = Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3 | journal = J Biochem | volume = 123 | issue = 5 | pages = 883–90 |date=Jul 1998 | pmid = 9562621 | doi = 10.1093/oxfordjournals.jbchem.a022020| doi-access = free }}] Its protein product is an [RNase](/source/RNase) enzyme homologous to the yeast protein [Rrp44](/source/Rrp44), and can be part of the [exosome complex](/source/exosome_complex) in the nucleus of eukaryotic cells.[{{cite web | title = Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22894}}][{{cite journal
|last2=Kristiansen
|first2=MS
|last3=Lykke-Andersen
|first3=S
|last4=Chlebowski
|first4=A
|last5=Larsen
|first5=KM
|last6=Szczesny
|first6=RJ
|last7=Drazkowska
|first7=K
|last8=Pastula
|first8=A
|last9=Andersen
|first9=JS
|last10=Stepien
|first10=Piotr P
|last11=Dziembowski
|first11=Andrzej
|last12=Jensen
|first12=Torben Heick
|title=The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L
|journal=The EMBO Journal
|volume=29
|issue=14
|pages=2342–57
|year=2010
|pmid=20531386
|pmc=2910271
|doi=10.1038/emboj.2010.121
|display-authors=8
|last1 = Tomecki|first1 = R.}}]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
*{{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
*{{cite journal | vauthors=Nagase T, Ishikawa K, Suyama M |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Brouwer R, Allmang C, Raijmakers R |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 |display-authors=etal|doi-access=free |hdl=2066/186951 |hdl-access=free }}
*{{cite journal | vauthors=Chen CY, Gherzi R, Ong SE |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi=10.1016/S0092-8674(01)00578-5 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809–18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 |hdl= 2066/261980 |hdl-access= free }}
*{{cite journal | vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653–63 |year= 2002 |pmid= 12419256 |doi=10.1016/S0022-2836(02)00947-6 |hdl=2066/186665 |hdl-access=free }}
*{{cite journal | vauthors=Scherl A, Couté Y, Déon C |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 |display-authors=etal}}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |bibcode=2004Natur.428..522D |display-authors=etal}}
*{{cite journal | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 |display-authors=etal}}
{{refend}}
{{gene-13-stub}}
Category:Genes on human chromosome 13
---
Adapted from the Wikipedia article [DIS3](https://en.wikipedia.org/wiki/DIS3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DIS3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.