# DHPS

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> Source: https://en.wikipedia.org/wiki/DHPS
> Source revision: 1301318609
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{about|the gene coding for the enzyme deoxyhypusine synthase|another enzyme commonly abbreviated DHPS|Dihydropteroate synthetase|other uses|DHPS (disambiguation)}}
{{Infobox_gene}}
'''Deoxyhypusine synthase''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''DHPS'' [gene](/source/gene).<ref name="pmid7673224">{{cite journal | vauthors = Joe YA, Wolff EC, Park MH | title = Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins | journal = J Biol Chem | volume = 270 | issue = 38 | pages = 22386–92 |date=Oct 1995 | pmid = 7673224 | doi =  10.1074/jbc.270.38.22386| doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DHPS deoxyhypusine synthase| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1725}}</ref>

The unusual amino acid [hypusine](/source/hypusine) is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A ([EIF5A](/source/EIF5A), [EIF5A2](/source/EIF5A2)). In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the [NAD](/source/Nicotinamide_adenine_dinucleotide)-dependent transfer of the [butylamine](/source/n-Butylamine) moiety of [spermidine](/source/spermidine) to the epsilon-amino group of a specific [lysine](/source/lysine) residue of the EIF5A precursor protein to form the intermediate [deoxyhypusine](/source/deoxyhypusine) residue. This gene consists of nine [exons](/source/exons) spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.<ref name="entrez"/>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Klier H |title=Purification and characterization of human deoxyhypusine synthase from HeLa cells |journal=FEBS Lett. |volume=364 |issue= 2 |pages= 207–10 |year= 1995 |pmid= 7750572 |doi=10.1016/0014-5793(95)00394-O  |name-list-style=vanc| author2=Csonga R  | author3=Steinkasserer A  | display-authors=3  | last4=Wohl  | first4=T  | last5=Lottspeich  | first5=F  | last6=Eder  | first6=J  |s2cid=24485865 |doi-access=free}}
*{{cite journal  | vauthors=Joe YA, Park MH |title=Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25916–21 |year= 1994 |doi=10.1016/S0021-9258(18)47333-4 |pmid= 7929297 |doi-access=free }}
*{{cite journal  | author=Bevec D |title=Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus |journal=FEBS Lett. |volume=378 |issue= 2 |pages= 195–8 |year= 1996 |pmid= 8549832 |doi=10.1016/0014-5793(95)01456-X  |name-list-style=vanc| author2=Kappel B  | author3=Jaksche H  | display-authors=3  | last4=Csonga  | first4=R  | last5=Hauber  | first5=J  | last6=Klier  | first6=H  | last7=Steinkasserer  | first7=A  |s2cid=39329481 | doi-access=  }}
*{{cite journal  | vauthors=Yan YP, Tao Y, Chen KY |title=Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information |journal=Biochem. J. |volume=315 |issue=  2|pages= 429–34 |year= 1996 |pmid= 8615810 |doi=  10.1042/bj3150429| pmc=1217213  }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-style=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal  | author=Jones T |title=The gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19p13.11-p13.12 |journal=Genomics |volume=35 |issue= 3 |pages= 635–7 |year= 1996 |pmid= 8812510 |doi= 10.1006/geno.1996.0416  |name-list-style=vanc| author2=Sheer D  | author3=Kapetanopoulos A  | display-authors=3  | last4=Hauber  | first4=Joachim  | last5=Bevec  | first5=Dorian  | last6=Steinkasserer  | first6=Alexander }}
*{{cite journal  | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-style=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
*{{cite journal  | vauthors=Liao DI, Wolff EC, Park MH, Davies DR |title=Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site |journal=Structure |volume=6 |issue= 1 |pages= 23–32 |year= 1998 |pmid= 9493264 |doi=10.1016/S0969-2126(98)00004-5  |doi-access=free }}
*{{cite journal  | author=Mantuano E |title=Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1 |journal=Gene |volume=215 |issue= 1 |pages= 153–7 |year= 1998 |pmid= 9666110 |doi=10.1016/S0378-1119(98)00254-6  |name-list-style=vanc| author2=Trettel F  | author3=Olsen AS  | display-authors=3  | last4=Lennon  | first4=G  | last5=Frontali  | first5=M  | last6=Jodice  | first6=C  |hdl=2108/46188 | url=https://art.torvergata.it/bitstream/2108/46188/1/28%20-%201998%20Gene%20215.pdf  | hdl-access=free  }}
*{{cite journal  | author=Lee YB |title=Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor |journal=Biochem. J. |volume=340 |issue=  1|pages= 273–81 |year= 1999 |pmid= 10229683 |doi=10.1042/0264-6021:3400273  | pmc=1220246  |name-list-style=vanc| author2=Joe YA  | author3=Wolff EC  | display-authors=3  | last4=Dimitriadis  | first4=Emilios K.  | last5=Park  | first5=Myung Hee  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | vauthors=Ober D, Harms R, Witte L, Hartmann T |title=Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12805–12 |year= 2003 |pmid= 12562768 |doi= 10.1074/jbc.M207112200 |doi-access= free }}
*{{cite journal  | vauthors=Park JH, Wolff EC, Folk JE, Park MH |title=Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 32683–91 |year= 2003 |pmid= 12788913 |doi= 10.1074/jbc.M304247200 |doi-access= free }}
*{{cite journal  | vauthors=Kang KR, Chung SI |title=Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells |journal=Exp. Mol. Med. |volume=35 |issue= 6 |pages= 556–64 |year= 2004 |pmid= 14749535 |doi=  10.1038/emm.2003.73|doi-access=free }}
*{{cite journal  | vauthors=Umland TC, Wolff EC, Park MH, Davies DR |title=A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28697–705 |year= 2004 |pmid= 15100216 |doi= 10.1074/jbc.M404095200 |doi-access= free }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-style=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-style=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
{{refend}}
{{PDB Gallery|geneid=1725}}

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Adapted from the Wikipedia article [DHPS](https://en.wikipedia.org/wiki/DHPS) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DHPS?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.