# DEPDC7

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**DEP Domain Containing Protein 7** (**DEPDC7**) is a protein of unknown function located on [chromosome 11](/source/Chromosome_11) bases 33,015,863-33,033,581.[1] The cytogenetic location is 11p13.[1] DEPDC7 has several aliases: DEP Domain Containing 7, DJ85M6.4, Novel 58.3 KDA Protein, Protein TR2/D15, and TR2.[2] The DEPDC7 gene is 17,718 base pairs long and has 8 [exons](/source/Exon) and 9 [introns](/source/Intron).[3] The gene is capable of making 6 different [mRNA transcripts](/source/Transcription_(biology)).[3] Two functional domains can be found within this gene's sequence: [DEP (Dishevelled, Egl-10, and Pleckstrin) domain](/source/DEP_domain) and [RhoGAP domain](/source/RhoGAP_domain).[4]

## mRNA

Transcription produces 4 alternatively spliced variants and 2 unspliced forms.[3] [Isoform](/source/Protein_isoform) 1 is the longest of all the variants containing all 8 exons.[4] It codes for 511 [amino acids](/source/Amino_acid).[4] [Northern blot](/source/Northern_blot) analysis detected that the DEPDC7 transcript in humans was expressed highly in the [liver](/source/Liver) and moderately expressed in the [kidney](/source/Kidney).[1] Hypomethylation of one of the DEPDC7 introns was related to the appearance of [depression](/source/Depression_(mood)) symptoms.[5]

## Protein

The protein is 511 amino acids long and has a [molecular weight](/source/Molecular-weight) of 58310.[6] DEPDC7 could have a role in tumor suppression. Overexpression inhibits the proliferation of [hepatoma](/source/Hepatoma) cells blocks the cell cycle transition from the [G0](/source/G0_phase)/[G1](/source/G1_phase) to [S phase](/source/S_phase), and inhibits the migration and invasion of hematoma cells.[7] DEPDC7 could potentially regulate neural development and physiology and could participate in [epigenetic](/source/Epigenetics) processes of [striatal neurons](/source/Striatal_neurons).[8] Genomic rearrangement within 11p12 and 11p14 were associated with [WAGR syndrome](/source/WAGR_syndrome).[9]

## DEP Domain

[DEP domain](/source/DEP_domain) is named after the 3 proteins it was initially found in: [Dishevelled](/source/Dishevelled), Egl-10, and [Pleckstrin](/source/Pleckstrin).[3] Dishevelled plays a key role in the transduction of the Wg/Wnt signal.[3] This signal goes from the cell surface to the nucleus.[3] Dishevelled is a segment polarity protein needed to make coherent arrays of polarized cells and segments in [embryos](/source/Embryo).[3] It also plays a role in wingless signaling. Egl-10 regulates G-protein signaling in the central nervous system.[3] Pleckstrin has 2 PH domains flanking the DEP domain and is the major substrate of protein kinase C in platelets.[3] The DEP domain within DEPDC7 was found to bind with CARMA2 and CARMA3 proteins.[10]

## Paralog

DEPDC7 has a paralog: [DEPDC1B](/source/DEPDC1B), a protein coding gene.

## References

1. ["OMIM Entry - * 612294 - DEP DOMAIN-CONTAINING PROTEIN 7; DEPDC7"](https://www.omim.org/entry/612294). *www.omim.org*. Retrieved 2019-02-11.

1. ["www.genecards.org/cgi-bin/carddisp.pl"](https://www.genecards.org/cgi-bin/carddisp.pl). *www.genecards.org*. Retrieved 2019-02-11.

1. ["AceView: gene:DEPDC7, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView."](https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&c=gene&q=DEPDC7&a=fgene&h=1&vr=v74a). *www.ncbi.nlm.nih.gov*. Retrieved 2019-02-11.

1. ["Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA"](https://www.ncbi.nlm.nih.gov/nuccore/NM_001077242.2). 2018-11-22.

1. Córdova-Palomera, A.; Fatjó-Vilas, M.; Palma-Gudiel, H.; Blasco-Fontecilla, H.; Kebir, O.; Fañanás, L. (September 2015). "Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins". *European Psychiatry*. **30** (6): 715–718. [doi:10.1016/j.eurpsy.2015.04.001](https://doi.org/10.1016/j.eurpsy.2015.04.001). [ISSN 0924-9338](https://www.worldcat.org/issn/0924-9338). [PMID 25952135](https://pubmed.ncbi.nlm.nih.gov/25952135). [S2CID 33225192](https://api.semanticscholar.org/CorpusID:33225192)

1. ["The European Bioinformatics Institute < EMBL-EBI"](https://www.ebi.ac.uk/). *www.ebi.ac.uk*. Retrieved 2019-02-11.

1. Liao, Zhijun; Wang, Xinrui; Wang, Xiaojiang; Li, Lisheng; Lin, Dexin (2017-10-03). "DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells". *Oncology Letters*. **14** (6): 7332–7338. [doi:10.3892/ol.2017.7128](https://doi.org/10.3892/ol.2017.7128). [ISSN 1792-1074](https://www.worldcat.org/issn/1792-1074). [PMC 5755016](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755016). [PMID 29344171](https://pubmed.ncbi.nlm.nih.gov/29344171)

1. Liao, Zhijun; Wang, Xinrui; Lin, Dexin; Zou, Quan (2016-03-25). "Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene". *[Interdisciplinary Sciences: Computational Life Sciences](/source/Interdisciplinary_Sciences:_Computational_Life_Sciences)*. **9** (3): 350–356. [doi:10.1007/s12539-016-0162-y](https://doi.org/10.1007/s12539-016-0162-y). [ISSN 1913-2751](https://www.worldcat.org/issn/1913-2751). [PMID 27016254](https://pubmed.ncbi.nlm.nih.gov/27016254). [S2CID 7150784](https://api.semanticscholar.org/CorpusID:7150784)

1. Seabra, Catarina M; Quental, Sofia; Neto, Ana Paula; Carvalho, Filipa; Gonçalves, João; Oliveira, João Paulo; Fernandes, Susana; Sousa, Mário; Barros, Alberto (September 2014). "A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia". *Reproductive BioMedicine Online*. **29** (3): 388–391. [doi:10.1016/j.rbmo.2014.04.017](https://doi.org/10.1016/j.rbmo.2014.04.017). [ISSN 1472-6483](https://www.worldcat.org/issn/1472-6483). [PMID 24912414](https://pubmed.ncbi.nlm.nih.gov/24912414)

1. D′ Andrea, Egildo Luca; Ferravante, Angela; Scudiero, Ivan; Zotti, Tiziana; Reale, Carla; Pizzulo, Maddalena; De La Motte, Luigi Regenburgh; De Maio, Chiara; Mazzone, Pellegrino (2014-12-26). "The Dishevelled, EGL-10 and Pleckstrin (DEP) Domain-Containing Protein DEPDC7 Binds to CARMA2 and CARMA3 Proteins, and Regulates NF-κB Activation". *PLOS ONE*. **9** (12). [Bibcode:2014PLoSO...9k6062D](https://ui.adsabs.harvard.edu/abs/2014PLoSO...9k6062D). [doi:10.1371/journal.pone.0116062](https://doi.org/10.1371/journal.pone.0116062). [ISSN 1932-6203](https://www.worldcat.org/issn/1932-6203). [PMC 4277425](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277425). [PMID 25541973](https://pubmed.ncbi.nlm.nih.gov/25541973)

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Adapted from the Wikipedia article [DEPDC7](https://en.wikipedia.org/wiki/DEPDC7) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DEPDC7?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.