# DDX5

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{{Short description|Protein-coding gene in Homo sapiens}}
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'''Probable ATP-dependent RNA helicase DDX5''' also known as '''DEAD box protein 5''' or '''RNA helicase p68''' is an [enzyme](/source/enzyme) that in humans is encoded by the ''DDX5'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1655}}</ref>

== Function ==

[DEAD box](/source/DEAD_box) proteins, characterized by the conserved motif [Asp](/source/Aspartic_acid)-[Glu](/source/Glutamic_acid)-[Ala](/source/Alanine)-Asp (DEAD), are putative [RNA helicase](/source/RNA_helicase)s. They are implicated in a number of cellular processes involving alteration of [RNA secondary structure](/source/RNA_secondary_structure), such as [translation initiation](/source/translation_initiation), nuclear and mitochondrial [splicing](/source/RNA_splicing), and [ribosome](/source/ribosome) and [spliceosome](/source/spliceosome) assembly. Based on their distribution patterns, some members of this family are believed to be involved in [embryogenesis](/source/embryogenesis), [spermatogenesis](/source/spermatogenesis),<ref>{{cite journal |last1=Legrand |first1=JMD |last2=Chan |first2=AL |last3=La |first3=HM |last4=Rossello |first4=FJ |last5=Änkö |first5=ML |last6=Fuller-Pace |first6=FV |last7=Hobbs |first7=RM |title=DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia. |journal=Nature Communications |date=23 May 2019 |volume=10 |issue=1 |pages=2278 |doi=10.1038/s41467-019-09972-7 |pmid=31123254|pmc=6533336 |bibcode=2019NatCo..10.2278L }}</ref> and [cellular growth](/source/cellular_growth) and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the [simian virus 40 tumor antigen](/source/simian_virus_40_tumor_antigen). This gene consists of 13 [exon](/source/exon)s, and [alternatively spliced](/source/alternatively_spliced) transcripts containing several [intron](/source/intron) sequences have been detected, but no isoforms encoded by these transcripts have been identified.<ref name="entrez" />

==Interactions==
DDX5 has been shown to [interact](/source/Protein-protein_interaction) with:
* [AKAP8](/source/AKAP8),<ref name="pmid11279182">{{cite journal | vauthors = Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM | title = A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17448–54 |date=May 2001 | pmid = 11279182 | doi = 10.1074/jbc.M101171200 | doi-access = free }}</ref>
*  [DDX17](/source/DDX17) (p72),<ref name="pmid12595555">{{cite journal | vauthors = Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV | title = The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells | journal = Nucleic Acids Res. | volume = 31 | issue = 5 | pages = 1470–80 |date=March 2003 | pmid = 12595555 | pmc = 149829 | doi = 10.1093/nar/gkg236 }}</ref>
* [DHX9](/source/DHX9) (RNA helicase A),<ref name="pmid18005418">{{cite journal | vauthors = Wilson BJ, Giguère V | title = Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis | journal = BMC Genomics | volume = 8| pages = 419 | year = 2007 | pmid = 18005418 | doi = 10.1186/1471-2164-8-419 | pmc=3225811 | doi-access = free }}</ref>
* [Estrogen receptor alpha](/source/Estrogen_receptor_alpha),<ref name="pmid12527917">{{cite journal | vauthors = Rossow KL, Janknecht R | title = Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300 | journal = Oncogene | volume = 22 | issue = 1 | pages = 151–6 |date=January 2003 | pmid = 12527917 | doi = 10.1038/sj.onc.1206067 | doi-access = free }}</ref>
* [Fibrillarin](/source/Fibrillarin),<ref name="pmid10837141">{{cite journal | vauthors = Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV | title = The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase | journal = Exp. Cell Res. | volume = 257 | issue = 2 | pages = 272–80 |date=June 2000 | pmid = 10837141 | doi = 10.1006/excr.2000.4886 }}</ref>
* [HDAC1](/source/HDAC1),<ref name="pmid15298701">{{cite journal | vauthors = Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV | title = The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner | journal = BMC Mol. Biol. | volume = 5| article-number = 11 |date=August 2004 | pmid = 15298701 | pmc = 514542 | doi = 10.1186/1471-2199-5-11 | doi-access = free }}</ref>
* [p53](/source/p53),<ref name="pmid15660129">{{cite journal | vauthors = Bates GJ, Nicol SM, Wilson BJ, Jacobs AM, Bourdon JC, Wardrop J, Gregory DJ, Lane DP, Perkins ND, Fuller-Pace FV | title = The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor | journal = EMBO J. | volume = 24 | issue = 3 | pages = 543–53 |date=February 2005 | pmid = 15660129 | pmc = 548656 | doi = 10.1038/sj.emboj.7600550 }}</ref>
* [CTCF](/source/CTCF).<ref name="pmid20966046">{{cite journal | vauthors = Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G | title = Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA | journal = Genes Dev | volume = 24 | issue = 22 | pages = 2543–2555 | year = 2010 |pmid = 20966046 | pmc = 2975930| doi = 10.1101/gad.1967810 }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Iggo RD, Jamieson DJ, MacNeill SA |title=p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1326–33 |year= 1991 |pmid= 1996094 |doi=  10.1128/MCB.11.3.1326| pmc=369403  |display-authors=etal}}
*{{cite journal  | vauthors=Hloch P, Schiedner G, Stahl H |title=Complete cDNA sequence of the human p68 protein |journal=Nucleic Acids Res. |volume=18 |issue= 10 |pages= 3045 |year= 1990 |pmid= 2349099 |doi=10.1093/nar/18.10.3045  | pmc=330836  }}
*{{cite journal  | vauthors=Ford MJ, Anton IA, Lane DP |title=Nuclear protein with sequence homology to translation initiation factor eIF-4A |journal=Nature |volume=332 |issue= 6166 |pages= 736–8 |year= 1988 |pmid= 2451786 |doi= 10.1038/332736a0 |bibcode=1988Natur.332..736F |s2cid=4351448 }}
*{{cite journal  | vauthors=Iggo R, Gough A, Xu W |title=Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 16 |pages= 6211–4 |year= 1989 |pmid= 2762324 |doi=10.1073/pnas.86.16.6211  | pmc=297807  |bibcode=1989PNAS...86.6211I |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Buelt MK, Glidden BJ, Storm DR |title=Regulation of p68 RNA helicase by calmodulin and protein kinase C |journal=J. Biol. Chem. |volume=269 |issue= 47 |pages= 29367–70 |year= 1994 |doi=10.1016/S0021-9258(18)43885-9 |pmid= 7525583 |doi-access=free }}
*{{cite journal  | vauthors=Brody LC, Abel KJ, Castilla LH |title=Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17 |journal=Genomics |volume=25 |issue= 1 |pages= 238–47 |year= 1995 |pmid= 7774924 |doi=10.1016/0888-7543(95)80131-5  |display-authors=etal|url=https://zenodo.org/record/1258609 |doi-access=free }}
*{{cite journal  | vauthors=Rössler OG, Hloch P, Schütz N |title=Structure and expression of the human p68 RNA helicase gene |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 932–9 |year= 2000 |pmid= 10648785 |doi=10.1093/nar/28.4.932  | pmc=102575  |display-authors=etal}}
*{{cite journal  | vauthors=Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV |title=The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 272–80 |year= 2000 |pmid= 10837141 |doi= 10.1006/excr.2000.4886 }}
*{{cite journal  | vauthors=Akileswaran L, Taraska JW, Sayer JA |title=A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17448–54 |year= 2001 |pmid= 11279182 |doi= 10.1074/jbc.M101171200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  |s2cid=14132033 |display-authors=etal|doi-access=free |bibcode=2002CBio...12....1A }}
*{{cite journal  | vauthors=Jurica MS, Licklider LJ, Gygi SR |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266  |display-authors=etal |article-number=S1355838202021088 }}
*{{cite journal  | author=Liu ZR |title=p68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5′ Splice Site Duplex |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5443–50 |year= 2002 |pmid= 12101238 |doi=10.1128/MCB.22.15.5443-5450.2002  | pmc=133941  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Rossow KL, Janknecht R |title=Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300 |journal=Oncogene |volume=22 |issue= 1 |pages= 151–6 |year= 2003 |pmid= 12527917 |doi= 10.1038/sj.onc.1206067 |doi-access= free }}
*{{cite journal  | vauthors=Guil S, Gattoni R, Carrascal M |title=Roles of hnRNP A1, SR Proteins, and p68 Helicase in c-H-ras Alternative Splicing Regulation |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2927–41 |year= 2003 |pmid= 12665590 |doi=10.1128/MCB.23.8.2927-2941.2003  | pmc=152554  |display-authors=etal}}
*{{cite journal  | vauthors=Fujita T, Kobayashi Y, Wada O |title=Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26704–14 |year= 2003 |pmid= 12738788 |doi= 10.1074/jbc.M301031200 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
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Category:EC 3.6.4

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Adapted from the Wikipedia article [DDX5](https://en.wikipedia.org/wiki/DDX5) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DDX5?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.