# DAAM1

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**Dishevelled-associated activator of morphogenesis 1** is a [protein](/source/Protein) that in humans is encoded by the *DAAM1* [gene](/source/Gene).[1][2][3] Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

## Function

[Cell motility](/source/Cell_motility), [adhesion](/source/Cell_adhesion), and [cytokinesis](/source/Cytokinesis), and other functions of the [cell cortex](/source/Cell_cortex) are mediated by the reorganization of the [actin](/source/Actin) [cytoskeleton](/source/Cytoskeleton) and recent evidence suggests a role for [formin homology](/source/Formins) (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small [GTPase](/source/GTPase) [Rho](/source/RHOA), a key regulator of cytoskeleton architecture, to control [cell polarity](/source/Cell_polarity) and movement during development. Activation requires [Dvl](/source/Dishevelled)-[Rho](/source/RHOA) complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.[3]

## Clinical significance

The deletion of a single copy of this gene has been associated with [congenital heart defects](/source/Congenital_heart_defect).[4]

## References

1. Habas R, Kato Y, He X (Jan 2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1". *Cell*. **107** (7): 843–54. [doi:10.1016/S0092-8674(01)00614-6](https://doi.org/10.1016/S0092-8674(01)00614-6). [PMID 11779461](https://pubmed.ncbi.nlm.nih.gov/11779461)

1. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R (Jan 2008). "Mechanism of activation of the Formin protein Daam1". *Proc Natl Acad Sci U S A*. **105** (1): 210–5. [Bibcode:2008PNAS..105..210L](https://ui.adsabs.harvard.edu/abs/2008PNAS..105..210L). [doi:10.1073/pnas.0707277105](https://doi.org/10.1073/pnas.0707277105). [PMC 2224188](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224188). [PMID 18162551](https://pubmed.ncbi.nlm.nih.gov/18162551)

1. ["Entrez Gene: DAAM1 dishevelled associated activator of morphogenesis 1"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23002)

1. Bao B, Zhang L, Hu H, Yin S, Liang Z (August 2012). "Deletion of a single-copy DAAM1 gene in congenital heart defect: a case report". *BMC Med. Genet.*. **13** (1): 63. [doi:10.1186/1471-2350-13-63](https://doi.org/10.1186/1471-2350-13-63). [PMC 3482563](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482563). [PMID 22857009](https://pubmed.ncbi.nlm.nih.gov/22857009)

## Further reading

- Tanaka K (2000). "Formin family proteins in cytoskeletal control.". *Biochem. Biophys. Res. Commun.*. **267** (2): 479–81. [doi:10.1006/bbrc.1999.1707](https://doi.org/10.1006/bbrc.1999.1707). [PMID 10631086](https://pubmed.ncbi.nlm.nih.gov/10631086)
- Ishikawa K, Nagase T, Suyama M (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". *DNA Res.*. **5** (3): 169–76. [doi:10.1093/dnares/5.3.169](https://doi.org/10.1093/dnares/5.3.169). [PMID 9734811](https://pubmed.ncbi.nlm.nih.gov/9734811)
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". *Proc. Natl. Acad. Sci. U.S.A.*. **99** (26): 16899–903. [Bibcode:2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi:10.1073/pnas.242603899](https://doi.org/10.1073/pnas.242603899). [PMC 139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID 12477932](https://pubmed.ncbi.nlm.nih.gov/12477932)
- Heilig R, Eckenberg R, Petit JL (2003). "The DNA sequence and analysis of human chromosome 14.". *Nature*. **421** (6923): 601–7. [Bibcode:2003Natur.421..601H](https://ui.adsabs.harvard.edu/abs/2003Natur.421..601H). [doi:10.1038/nature01348](https://doi.org/10.1038/nature01348). [PMID 12508121](https://pubmed.ncbi.nlm.nih.gov/12508121)
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". *Nat. Genet.*. **36** (1): 40–5. [doi:10.1038/ng1285](https://doi.org/10.1038/ng1285). [PMID 14702039](https://pubmed.ncbi.nlm.nih.gov/14702039)
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". *Genome Res.*. **14** (10B): 2121–7. [doi:10.1101/gr.2596504](https://doi.org/10.1101/gr.2596504). [PMC 528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID 15489334](https://pubmed.ncbi.nlm.nih.gov/15489334)
- Aspenström P, Richnau N, Johansson AS (2006). "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.". *Exp. Cell Res.*. **312** (12): 2180–94. [doi:10.1016/j.yexcr.2006.03.013](https://doi.org/10.1016/j.yexcr.2006.03.013). [PMID 16630611](https://pubmed.ncbi.nlm.nih.gov/16630611)
- Sato A, Khadka DK, Liu W (2007). "Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation.". *Development*. **133** (21): 4219–31. [doi:10.1242/dev.02590](https://doi.org/10.1242/dev.02590). [PMID 17021034](https://pubmed.ncbi.nlm.nih.gov/17021034)
- Lu J, Meng W, Poy F (2007). "Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly.". *J. Mol. Biol.*. **369** (5): 1258–69. [doi:10.1016/j.jmb.2007.04.002](https://doi.org/10.1016/j.jmb.2007.04.002). [PMC 1939941](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939941). [PMID 17482208](https://pubmed.ncbi.nlm.nih.gov/17482208)

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Adapted from the Wikipedia article [DAAM1](https://en.wikipedia.org/wiki/DAAM1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/DAAM1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.