# CtRNA

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CtRNA
> Markdown URL: https://mediated.wiki/source/CtRNA.md
> Source: https://en.wikipedia.org/wiki/CtRNA
> Source revision: 1285191391
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{lowercase}}

{{Infobox rfam
| Name = ctRNA
| image = RF00489.jpg
| width = 
| caption = Predicted [secondary structure](/source/secondary_structure) and [sequence conservation](/source/sequence_conservation) of ctRNA_p42d
| Symbol = ctRNA_p42d
| AltSymbols = 
| Rfam = RF00489
| miRBase = 
| miRBase_family = 
| RNA_type = [Gene](/source/Gene); [antisense](/source/Antisense_RNA)
| Tax_domain = [Bacteria](/source/Bacteria)
| GO = 
| SO = {{SO|0000644}} 
| CAS_number = 
| EntrezGene = 
| HGNCid = 
| OMIM = 
| PDB = 
| RefSeq = 
| Chromosome = 
| Arm = 
| Band = 
| LocusSupplementaryData = 
}}

In molecular biology '''ctRNA''' (counter-transcribed [RNA](/source/RNA)) is a plasmid encoded [noncoding RNA](/source/noncoding_RNA) that binds to the [mRNA](/source/mRNA) of {{chem name|repB}} and causes [translational](/source/translation_(genetics)) inhibition.<ref name="Ven03">{{cite journal | last = Venkova-Canova | first = T |author2=Patek M |author3=Nesvera J  | year = 2003 | title = Control of rep gene expression in plasmid pGA1 from Corynebacterium glutamicum | journal = J Bacteriol | volume = 185 | pages = 2402–2409 | pmid = 12670963 | doi = 10.1128/JB.185.8.2402-2409.2003 | issue = 8 | pmc = 152619}}</ref>
ctRNA is encoded by plasmids and functions in [rolling circle replication](/source/rolling_circle_replication) to maintain a low copy number. In ''[Corynebacterium glutamicum](/source/Corynebacterium)'', it achieves this by [antisense](/source/antisense) pairing with the mRNA of {{chem name|RepB}}, a [replication](/source/self-replication) initiation protein.<ref name="Ven03" />
In ''[Enterococcus faecium](/source/Enterococcus_faecium)'' the plasmid pJB01 contains three open reading frames, copA, {{chem name|repB}}, and {{chem name|repC}}. The pJB01 ctRNA is coded on the opposite strand from the {{chem name|copA}}/{{chem name|repB}} intergenic region and partially overlaps an atypical ribosome binding site for {{chem name|repB}}.<ref name="pmid18511887">{{cite journal |vauthors=Kim SW, Jeong IS, Jeong EJ |title=The terminal and internal hairpin loops of the ctRNA of plasmid pJB01 play critical roles in regulating copy number |journal=Mol. Cells |volume=26 |issue=1 |pages=26–33 |date=July 2008 |pmid=18511887 |display-authors=etal}}</ref>

==See also==
*[S-element](/source/S-element)

==References==
{{reflist}}

==External links==
* {{Rfam|id=RF00236|name=ctRNA_pGA1}}
* {{Rfam|id=RF00489|name=ctRNA_p42d}}
* {{Rfam|id=RF00238|name=ctRNA_pND324}}
* {{Rfam|id=RF00242|name=ctRNA_pT181}}

Category:Antisense RNA
Category:Genetics techniques

{{molecular-cell-biology-stub}}

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Adapted from the Wikipedia article [CtRNA](https://en.wikipedia.org/wiki/CtRNA) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CtRNA?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.