# Craig plot

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{{One source|date=January 2024}}
thumb|Craig plot showing values of Hansch pi and Hammett sigma constants for 26 common organic substituents
The '''Craig plot''', named after Paul N. Craig, is a plot of two substituent parameters (e.g. [Hansch-Fujita π constant](/source/Hansch-Fujita_%CF%80_constant) and sigma constant) used in rational [drug design](/source/drug_design).<ref>{{Cite web |url=http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |title=IUPAC glossary |access-date=2006-12-14 |archive-url=https://web.archive.org/web/20061209044630/http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |archive-date=2006-12-09 |url-status=dead }}</ref>

Two most used forms of a Craig plot are
* plotting the sigma constants of the [Hammett equation](/source/Hammett_equation) versus [hydrophobicity](/source/hydrophobicity)
* plotting the steric terms of the [Taft equation](/source/Taft_equation) against [hydrophobicity](/source/hydrophobicity)

==See also==
* [Quantitative structure-activity relationship](/source/Quantitative_structure-activity_relationship)
* [pKa](/source/Acid_dissociation_constant)

==References==
{{Reflist}}

==Further reading==
* {{cite journal|doi=10.1021/jm00290a004 | volume=14 | title=Interdependence between physical parameters and selection of substituent groups for correlation studies | journal=Journal of Medicinal Chemistry | pages=680–684 | last1 = Craig | first1 = Paul N.| year=1971 | issue=8 | pmid=5114063 }}

Category:Medicinal chemistry

{{medicinal-chem-stub}}

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Adapted from the Wikipedia article [Craig plot](https://en.wikipedia.org/wiki/Craig_plot) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Craig_plot?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.