# Codoxime

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/Codoxime
> Markdown URL: https://mediated.wiki/source/Codoxime.md
> Source: https://en.wikipedia.org/wiki/Codoxime
> Source revision: 1268669723
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = (((4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ylidene)amino)oxy)acetic acid
| image = Codoxime.svg
| image_class = skin-invert-image
| width = 220

<!--Clinical data-->
| tradename =  
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category =  
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_BR = A1
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-03-31 |title=RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |url-status=live |archive-url=https://web.archive.org/web/20230803143925/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992 |archive-date=2023-08-03 |access-date=2023-08-16 |publisher=[Diário Oficial da União](/source/Di%C3%A1rio_Oficial_da_Uni%C3%A3o) |language=pt-BR |publication-date=2023-04-04}}</ref>
| legal_CA = Schedule I
| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
| legal_US =  
| legal_UN = N I
| legal_DE = Anlage I
| routes_of_administration =  

<!--Pharmacokinetic data-->
| bioavailability =  
| protein_bound =  
| metabolism =  
| elimination_half-life =  
| excretion =  

<!--Identifiers-->
| CAS_number = 7125-76-0
| ATC_prefix = none
| ATC_suffix =  
| PubChem = 9570253
| DrugBank =  
| ChEMBL = 2107300
| ChemSpiderID = 7844721
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = JT5I2F57F7
| KEGG = D03581

<!--Chemical data-->
| C=20 | H=24 | N=2 | O=5 
| smiles = O=C(O)CO\N=C4\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C
| synonyms = Codoxime
}}

'''Codoxime''' ('''Codossima''') is an [opiate](/source/opiate) analogue that is a derivative of [hydrocodone](/source/hydrocodone), where the 6-[ketone](/source/ketone) group has been replaced by carboxymethyloxime. It has primarily [antitussive](/source/antitussive) effects<ref>{{cite patent |country= US |number= 3153042 |status= granted |title= Morphinone and Codeinone Derivatives |pubdate= |gdate= 13 October 1964 |fdate= |pridate= |inventor = Jack Fishman |assign1= Mozes Juda Lowenstein }}</ref> and was found to have moderate potential to cause dependence in animal studies.<ref name="pmid6021586">{{cite journal | vauthors = Jasinski DR, Martin WR | title = Assessment of the dependence-producing properties of dihydrocodeinone and codoxime | journal = Clinical Pharmacology and Therapeutics | volume = 8 | issue = 2 | pages = 266–70 | date = 1967 | pmid = 6021586 | doi = 10.1002/cpt196782266 | s2cid = 36504901 }}</ref>

==References==
{{Reflist|2}}

{{Opioidergics}}

Category:Antitussives
Category:4,5-Epoxymorphinans
Category:Catechol ethers
Category:Mu-opioid receptor agonists
Category:Semisynthetic opioids

{{analgesic-stub}}

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Adapted from the Wikipedia article [Codoxime](https://en.wikipedia.org/wiki/Codoxime) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Codoxime?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.