# Capuride

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Sedative-hypnotic drug

Pharmaceutical compound

Capuride Clinical data Other names Pacinox, valnoctylurea Identifiers IUPAC name N-carbamoyl-2-ethyl-3-methylpentanamide CAS Number 5579-13-5 PubChem CID 231285 ChemSpider 201505 UNII 3FO9QT93IS KEGG D03377 ChEBI CHEBI:134831 ChEMBL ChEMBL392861 CompTox Dashboard (EPA) DTXSID5022728 Chemical and physical data Formula C9H18N2O2 Molar mass 186.255 g·mol−1 3D model (JSmol) Interactive image SMILES CCC(C)C(CC)C(=O)NC(=O)N InChI InChI=InChI=1S/C9H18N2O2/c1-4-6(3)7(5-2)8(12)11-9(10)13/h6-7H,4-5H2,1-3H3,(H3,10,11,12,13) Key:HLSLSXBFTXUKCY-UHFFFAOYSA-N

**Capuride** is a synthetic [sedative-hypnotic](/source/Sedative-hypnotic) drug of the [*N*-acylurea](/source/N-acylurea) class, primarily developed and studied as a [preanesthetic](/source/Preanesthetic) agent to promote sleep prior to surgery.[1] It has a mechanism and duration of action considered similar to that of short-acting [barbiturates](/source/Barbiturate), although it is chemically distinct. Clinical studies from the 1970s demonstrated capuride's efficacy in facilitating presurgical sleep, situating it among early modern hypnotic agents, but its clinical use has been superseded by safer alternatives.[2]

## References

1. **[^](#cite_ref-Katz_1970_1-0)** Katz J, Finestone SC, Pappas MT, Fine J (May 1970). "A double-blind evaluation of capuride (Pacinox) as a presurgical aid to sleep". *Current Therapeutic Research, Clinical and Experimental*. **12** (5): 255–260. [PMID](/source/PMID_(identifier)) [4986240](https://pubmed.ncbi.nlm.nih.gov/4986240).

1. **[^](#cite_ref-2)** Weiss H (February 1971). "Capuride for sleep in rehabilitation patients: a controlled trial". *Archives of Physical Medicine and Rehabilitation*. **52** (2): 68–72. [PMID](/source/PMID_(identifier)) [4927636](https://pubmed.ncbi.nlm.nih.gov/4927636).

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