# Calphostin C

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**Calphostin C** is a natural chemical compound. It is one of the [calphostins](/source/Calphostin), isolated from the fungus *[Cladosporium cladosporioides](/source/Cladosporium_cladosporioides)*.[1][2] Calphostin C is a potent [inhibitor](/source/Enzyme_inhibitor) of [protein kinase C](/source/Protein_kinase_C) (PKC).

## References

1. Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". *J. Antibiot.*. **42** (10): 1470–1474. [doi:10.7164/antibiotics.42.1470](https://doi.org/10.7164/antibiotics.42.1470). [PMID 2478514](https://pubmed.ncbi.nlm.nih.gov/2478514)

1. Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". *J. Antibiot.*. **42** (10): 1475–1481. [doi:10.7164/antibiotics.42.1475](https://doi.org/10.7164/antibiotics.42.1475). [PMID 2478515](https://pubmed.ncbi.nlm.nih.gov/2478515)

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Adapted from the Wikipedia article [Calphostin C](https://en.wikipedia.org/wiki/Calphostin_C) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Calphostin_C?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.