# Calphostin

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The **calphostins** are a class of closely related chemical compounds isolated from the fungus *[Cladosporium cladosporioides](/source/Cladosporium_cladosporioides)*.[1][2] The known calphostins include calphostin A, calphostin B, [calphostin C](/source/Calphostin_C), calphostin D, and calphostin I. The calphostins are [inhibitors](/source/Enzyme_inhibitor) of [protein kinase C](/source/Protein_kinase_C) (PKC).[1][2] The most potent member of the series, calphostin C,[1] has found use as a biochemical tool because of this activity.[3]

Calpohostin R1 R2 Calphostin A Bz Bz Calphostin B Bz H Calphostin C Bz 4-(HO)Bz Calphostin D H H Calphostin I 4-(HO)Bz 4-(HO)Bz

## Calphostin C

Main article: [Calphostin C](/source/Calphostin_C)

Calphostin C is a potent [inhibitor](/source/Enzyme_inhibitor) of [protein kinase C](/source/Protein_kinase_C) (PKC).[1][2][3]

## References

1. Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". *Journal of Antibiotics*. **42** (10): 1470–1474. [doi:10.7164/antibiotics.42.1470](https://doi.org/10.7164/antibiotics.42.1470). [PMID 2478514](https://pubmed.ncbi.nlm.nih.gov/2478514)

1. Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". *Journal of Antibiotics*. **42** (10): 1475–1481. [doi:10.7164/antibiotics.42.1475](https://doi.org/10.7164/antibiotics.42.1475). [PMID 2478515](https://pubmed.ncbi.nlm.nih.gov/2478515)

1. ["Calphostin C"](https://www.biomol.com/products/chemicals/biochemicals/calphostin-c-cay15383-100?fs=4064629640). Biomol GmbH. Retrieved 11 October 2024.

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