# CagZ

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CagZ
> Markdown URL: https://mediated.wiki/source/CagZ.md
> Source: https://en.wikipedia.org/wiki/CagZ
> Source revision: 1350877632
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{Short description|Protein produced by Helicobacter pylori bacteria}}
{{Infobox protein family
| Symbol = CagZ
| Name = CagZ
| image = PDB 1s2x EBI.jpg
| width = 
| caption = crystal structure of cag-z from helicobacter pylori
| Pfam = PF09053
| Pfam_clan =  
| InterPro = IPR015139
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}

In molecular biology, '''CagZ''' is a [protein](/source/protein) produced by ''[Helicobacter pylori](/source/Helicobacter_pylori)'' (''Campylobacter pylori''). It is a 23 kDa protein consisting of a single compact L-shaped domain, composed of seven [alpha-helices](/source/alpha_helix) that run [antiparallel](/source/Antiparallel_(biochemistry)) to each other. 70% of the amino acids are in [alpha-helix](/source/alpha-helix) conformation and no [beta-sheet](/source/beta-sheet) is present. CagZ is essential for the translocation of the [pathogenic](/source/pathogenic) protein CagA into host [cell](/source/cell_(biology))s.<ref name="pmid15223328">{{cite journal |vauthors=Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G | title = Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system | journal = J. Mol. Biol. | volume = 340 | issue = 4 | pages = 881–9 |date=July 2004 | pmid = 15223328 | doi = 10.1016/j.jmb.2004.05.016 }}</ref>

==References==
{{reflist}}
{{InterPro content|IPR015139}}

Category:Protein domains
Category:Helicobacter pylori

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Adapted from the Wikipedia article [CagZ](https://en.wikipedia.org/wiki/CagZ) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CagZ?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.