# CYM50769

> Mediated Wiki article. Canonical URL: https://mediated.wiki/source/CYM50769
> Markdown URL: https://mediated.wiki/source/CYM50769.md
> Source: https://en.wikipedia.org/wiki/CYM50769
> Source revision: 1330136083
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{cs1 config|name-list-style=vanc|display-authors=6}}
{{Drugbox
| IUPAC_name = 5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3-one
| image = CYM50769_structure.png
| image_class = skin-invert-image

<!--Clinical data-->
| tradename =  
| pregnancy_category =  
| legal_status =  
| routes_of_administration =

<!--Pharmacokinetic data-->
| bioavailability =  
| metabolism =  
| elimination_half-life =  
| excretion =

<!--Identifiers-->
| IUPHAR_ligand = 
| CAS_number = 1421365-63-0 
| ATC_prefix = none
| ATC_suffix =  
| PubChem = 50904505
| ChemSpiderID      = 28494696
| ChEMBL = 1972527
| UNII = 
<!--Chemical data-->
| C=24 | H=17 | Cl=1 | N=2 | O=3 
| StdInChI=1S/C24H17ClN2O3/c1-29-15-10-12-16(13-11-15)30-23-21(25)14-26-27(24(23)28)22-19-8-4-2-6-17(19)18-7-3-5-9-20(18)22/h2-14,22H,1H3
| StdInChIKey = QHVSQUYCVUHYKT-UHFFFAOYSA-N
| SMILES = COC1=CC=C(C=C1)OC2=C(C=NN(C2=O)C3C4=CC=CC=C4C5=CC=CC=C35)Cl
}}

'''CYM50769''' is a [drug](/source/drug) which acts as a [selective](/source/binding_selectivity), non-[peptide](/source/peptide) [antagonist](/source/Antagonist_(pharmacology)) at the [Neuropeptides B](/source/Neuropeptide_B)[/W](/source/Neuropeptide_W) [receptor](/source/Receptor_(biochemistry)) [NPBW1](/source/Neuropeptides_B%2FW_receptor_1). It is used for fundamental research into the structure and function of the NPBW1 receptor, and has [antidepressant](/source/antidepressant) effects in animal studies.<ref>{{cite journal | vauthors = Urbano M, Guerrero M, Zhao J, Velaparthi S, Saldanha SA, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E | title = Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) | journal = Bioorganic & Medicinal Chemistry Letters | volume = 22 | issue = 23 | pages = 7135–7141 | date = December 2012 | pmid = 23079522 | doi = 10.1016/j.bmcl.2012.09.074 | pmc = 3601546 }}</ref><ref>{{cite journal | vauthors = Guerrero M, Urbano M, Schaeffer MT, Brown S, Rosen H, Roberts E | title = SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists | journal = Bioorganic & Medicinal Chemistry Letters | volume = 23 | issue = 3 | pages = 614–619 | date = February 2013 | pmid = 23287738 | doi = 10.1016/j.bmcl.2012.12.030 | pmc = 3621982 }}</ref><ref>{{cite journal | vauthors = Stein G, Aly JS, Lange L, Manzolillo A, Riege K, Brancato A, Hübner CA, Turecki G, Hoffmann S, Engmann O | title = Npbwr1 signaling mediates fast antidepressant action | journal = Molecular Psychiatry | volume = 30 | issue = 5 | pages = 1828–1835 | date = May 2025 | pmid = 39433904 | doi = 10.1038/s41380-024-02790-4 | pmc = 12015170 }}</ref>

== References ==
{{Reflist}}

Category:Pyridazines
Category:Chloroarenes
Category:Lactams
Category:Fluorenes
Category:4-Methoxyphenyl compounds

{{nervous-system-drug-stub}}

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Adapted from the Wikipedia article [CYM50769](https://en.wikipedia.org/wiki/CYM50769) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/CYM50769?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.